Does norepinephrine influence pain behavior mediated by dorsal root ganglia? a pilot study

Clinical Orthopaedics and Related Research

Volumn 469, Issue 9, 2011, Pages 2568-2576

  Tanimoto, Katsumasa ^a   Takebayashi, Tsuneo ^a   Kobayashi, Takeshi ^a   Tohse, Noritsugu ^a   Yamashita, Toshihiko ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; NORADRENALIN; PHENTOLAMINE; YOHIMBINE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT;

ADRENERGIC ACTIVITY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; LOW BACK PAIN; MALE; NERVE EXCITABILITY; NERVE POTENTIAL; NERVE ROOT COMPRESSION; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RADICULAR PAIN; RAT; SENSORY SYSTEM ELECTROPHYSIOLOGY; SPIKE WAVE; SPINAL GANGLION; SPINAL ROOT; ACTION POTENTIAL; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; DRUG EFFECT; METABOLISM; PAIN; PAIN THRESHOLD; PATHOPHYSIOLOGY; PILOT STUDY; REACTION TIME; SPRAGUE DAWLEY RAT; SUTURING METHOD; TIME;

ACTION POTENTIALS; ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; MALE; NOREPINEPHRINE; PAIN; PAIN THRESHOLD; PATCH-CLAMP TECHNIQUES; PILOT PROJECTS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, ADRENERGIC, ALPHA-2; SUTURE TECHNIQUES; TIME FACTORS;

EID: 80053322821     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-011-1798-x     Document Type: Article

References (54)

1. Abdulla FA, Smith PA. Axotomy- and autotomy-induced changes in the excitability of rat dorsal root ganglion neurons. J Neurophysiol. 2001;85:630-643. (Pubitemid 32147766)
2. Atlas SJ, Deyo RA, Keller RB, Chapin AM, Patrick DL, Long JM, Singer DE. The Maine Lumbar Spine Study, Part II. 1-year outcomes of surgical and nonsurgical management of sciatica. Spine (Phila Pa 1976). 1996;21:1777-1786. (Pubitemid 26260294)
3. Atlas SJ, Keller RB, Chang Y, Deyo RA, Singer DE. Surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: five-year outcomes from the Maine Lumbar Spine Study. Spine (Phila Pa 1976). 2001;26:1179-1187. (Pubitemid 32429322)
4. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33:87-107.
5. Birder LA, Perl ER. Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. J Physiol. 1999;515 (Pt 2):533-542. (Pubitemid 29129223)
6. Boas RA. Sympathetic nerve blocks: in search of a role. Reg Anesth Pain Med. 1998;23:292-305. (Pubitemid 28368130)
7. Chen Y, Michaelis M, Janig W, Devor M. Adrenoreceptor sub-type mediating sympathetic-sensory coupling in injured sensory neurons. J Neurophysiol. 1996;76:3721-3730. (Pubitemid 27009676)
8. Cho HJ, Kim DS, Lee NH, Kim JK, Lee KM, Han KS, Kang YN, Kim KJ. Changes in the alpha 2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain. Neuroreport. 1997;8:3119-3122.
9. Chung K, Chung JM. Sympathetic sprouting in the dorsal root ganglion after spinal nerve ligation: evidence of regenerative collateral sprouting. Brain Res. 2001;895:204-212. (Pubitemid 32231157)
10. Chung K, Kim HJ, Na HS, Park MJ, Chung JM. Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain. Neurosci Lett. 1993;162: 85-88. (Pubitemid 23347952)
11. Devor M, Janig W, Michaelis M. Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve-injured rats. J Neurophysiol. 1994;71:38-47. (Pubitemid 24058839)
12. Goldstein DS. Plasma catecholamines and essential hypertension: an analytical review. Hypertension. 1983;5:86-99. (Pubitemid 13179794)
13. Harper AA, Lawson SN, Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J Physiol. 1985;359:31-46. (Pubitemid 15152926)
14. Hashizume H, DeLeo JA, Colburn RW, Weinstein JN. Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine (Phila PA 1976). 2000;25:1206-1217. (Pubitemid 30322310)
15. Honma Y, Yamakage M, Ninomiya T. Effects of adrenergic stimulus on the activities of Ca2 + and K + channels of dorsal root ganglion neurons in a neuropathic pain model. Brain Res. 1999;832:195-206. (Pubitemid 29336181)
16. Hu SJ, Xing JL. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat Pain. 1998;77:15-23.
17. Kawasaki Y, Kumamoto E, Furue H, Yoshimura M. Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons. Anesthesiology. 2003;98:682-689. (Pubitemid 36262595)
18. Khoromi S, Cui L, Nackers L, Max MB. Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain. Pain. 2007;130:66-75. (Pubitemid 46850784)
19. Khoromi S, Patsalides A, Parada S, Salehi V, Meegan JM, Max MB. Topiramate in chronic lumbar radicular pain. J Pain. 2005;6:829-836. (Pubitemid 41739600)
20. Kim SH, Chung JM. Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat Neurosci Lett. 1991;134:131-134.
21. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain. 1992;50:355-363.
22. Kim YI, Na HS, Kim SH, Han HC, Yoon YW, Sung B, Nam HJ, Shin SL, Hong SK. Cell type-specific changes of the membrane properties of peripherally- axotomized dorsal root ganglion neu-rons in a rat model of neuropathic pain. Neuroscience. 1998;86: 301-309. (Pubitemid 28270875)
23. Kirita T, Takebayashi T, Mizuno S, Takeuchi H, Kobayashi T, Fukao M, Yamashita T, Tohse N. Electrophysiologic changes in dorsal root ganglion neurons and behavioral changes in a lumbar radiculopathy model. Spine. 2007;32:E65-72. (Pubitemid 46105795)
24. Lee DH, Katner J, Iyengar S, Lodge D. The effect of lumbar sympathectomy on increased tactile sensitivity in spinal nerve ligated rats. Neurosci Lett. 2001;298:99-102. (Pubitemid 32037066)
25. Leem JW, Gwak YS, Nam TS, Paik KS. Involvement of alpha2-adrenoceptors in mediating sympathetic excitation of injured dorsal root ganglion neurons in rats with spinal nerve ligation. Neurosci Lett. 1997;234:39-42. (Pubitemid 27435964)
26. Ma C, Greenquist KW, Lamotte RH. Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons. J Neurophysiol. 2006;95:2098-2107.
27. Ma C, Shu Y, Zheng Z, Chen Y, Yao H, Greenquist KW, White FA, LaMotte RH. Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons. J Neurophysiol. 2003;89:1588-1602. (Pubitemid 36324002)
28. McLachlan EM, Janig W, Devor M, Michaelis M. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature. 1993;363:543-546. (Pubitemid 23186640)
29. Michaelis M, Devor M, Janig W. Sympathetic modulation of activity in rat dorsal root ganglion neurons changes over time following peripheral nerve injury. J Neurophysiol. 1996;76: 753-763. (Pubitemid 26284568)
30. Mizuno S, Takebayashi T, Kirita T, Tanimoto K, Tohse N, Yamashita T. The effects of the sympathetic nerves on lumbar radicular pain: a behavioural and immunohistochemical study. J Bone Joint Surg Br. 2007;89:1666-1672. (Pubitemid 351183422)
31. Murata Y, Olmarker K, Takahashi I, Takahashi K, Rydevik B. Effects of lumbar sympathectomy on pain behavioral changes caused by nucleus pulposus-induced spinal nerve damage in rats. Eur Spine J. 2006;15:634-640
32. Peng PW, Castano ED. Survey of chronic pain practice by anesthesiologists in Canada. Can JAnaesth. 2005;52:383-389. (Pubitemid 40753824)
33. Petersen M, Zhang J, Zhang JM, LaMotte RH. Abnormal spon-taneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction. Pain. 1996;67:391-397. (Pubitemid 26375356)
34. Ramer MS, Bisby MA. Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury. Pain. 1997;70:237-244. (Pubitemid 27179637)
35. Ramer MS, French GD, Bisby MA. Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG. Pain. 1997;72:71-78. (Pubitemid 27321903)
36. Scroggs RS, Fox AP. Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size. J Physiol. 1992;445:639-658.
37. Sekiguchi M, Kobayashi H, Sekiguchi Y, Konno S, Kikuchi S. Sympathectomy reduces mechanical allodynia, tumor necrosis factor-alpha expression, and dorsal root ganglion apoptosis fol-lowing nerve root crush injury. Spine. 2008;33:1163-1169. (Pubitemid 351677611)
38. Shi TS, Winzer-Serhan U, Leslie F, Hokfelt T. Distribution and regulation of alpha(2)-adrenoceptors in rat dorsal root ganglia. Pain. 2000;84:319-330. (Pubitemid 30074234)
39. Shinder V, Govrin-Lippmann R, Cohen S, Belenky M, Ilin P, Fried K, Wilkinson HA, Devor M. Structural basis of sympa-thetic-sensory coupling in rat and human dorsal root ganglia following peripheral nerve injury. J Neurocytol. 1999;28:743-761.
40. Song XJ, Zhang JM, Hu SJ, LaMotte RH. Somata of nerve-injured sensory neurons exhibit enhanced responses to inflam-matory mediators. Pain. 2003;104:701-709.
41. Stafford MA, Peng P, Hill DA. Sciatica: a review of history, epidemiology, pathogenesis, and the role of epidural steroid injection in management. Br J Anaesth. 2007;99:461-473. (Pubitemid 47412487)
42. Stone LS, Broberger C, Vulchanova L, Wilcox GL, Hokfelt T, Riedl MS, Elde R. Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci. 1998;18:5928-5937. (Pubitemid 28341368)
43. Stucky CL, Lewin GR. Isolectin B(4)-positive and -negative nociceptors are functionally distinct. J Neurosci. 1999;19:6497-6505. (Pubitemid 29347449)
44. Study RE, Kral MG. Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy. Pain. 1996;65:235-242. (Pubitemid 26228040)
45. Takebayashi T, Cavanaugh JM, Cuneyt Ozaktay A, Kallakuri S, Chen C. Effect of nucleus pulposus on the neural activity of dorsal root ganglion. Spine (Phila Pa 1976). 2001;26:940-945.
46. Tran KM, Frank SM, Raja SN, El-Rahmany HK, Kim LJ, Vu B. Lumbar sympathetic block for sympathetically maintained pain: changes in cutaneous temperatures and pain perception. Anesth Analg. 2000;90:1396-1401. (Pubitemid 30351344)
47. Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008;70:1630-1635. (Pubitemid 351620320)
48. Watanabe K, Konno S, Sekiguchi M, Sasaki N, Honda T, Kikuchi S. Increase of 200-kDa neurofilament-immunoreactive afferents in the substantia gelatinosa in allodynic rats induced by com-pression of the dorsal root ganglion. Spine (Phila Pa 1976). 2007;32:1265-1271. (Pubitemid 46791443)
49. Xie W, Strong JA, Li H, Zhang JM. Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block. J Neurophysiol. 2007;97:492-502. (Pubitemid 46143372)
50. Xie Y, Zhang J, Petersen M, LaMotte RH. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat J Neurophysiol. 1995;73:1811-1820.
51. Zhang JM, Donnelly DF, Song XJ, Lamotte RH. Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons. J Neurophysiol. 1997;78:2790-2794. (Pubitemid 27495502)
52. Zhang JM, Li H, Munir MA. Decreasing sympathetic sprouting in pathologic sensory ganglia: a new mechanism for treating neu-ropathic pain using lidocaine. Pain. 2004;109:143-149. (Pubitemid 38479780)
53. Zhang JM, Song XJ, LaMotte RH. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain. 1997;72: 51-57.
54. Zhang JM, Song XJ, LaMotte RH. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. J Neurophysiol. 1999;82:3359-3366. (Pubitemid 30017460)