Gene expression profiling of early-phase Sjögren's syndrome in C57BL/6.NOD-Aec1Aec2 mice identifies focal adhesion maturation associated with infiltrating leukocytes

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 8, 2011, Pages 5647-5655

  Peck, Ammon B ^a,b,c   Saylor, Benjamin T ^a   Nguyen, Linh ^d   Sharma, Ashok ^e   She, Jin Xiong ^e   Nguyen, Cuong Q ^a,c   McIndoe, Richard A ^e  

^a College of Dentistry ^*  (United States)

^b Department of Clinical and Health Psychology   (United States)

^c Department of Community Dentistry and Behavioral Science   (United States)

^d Georgia's Health Sciences University ^*  (United States)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN; SCLEROPROTEIN; SYNDECAN;

AGE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL INFILTRATION; CELL MATURATION; DESMOSOME; DNA MICROARRAY; FOCAL ADHESION; GAP JUNCTION; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LACRIMAL GLAND; LEUKOCYTE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; TIGHT JUNCTION; ANIMAL; C57BL MOUSE; EXTRACELLULAR MATRIX; FEMALE; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; LACRIMAL APPARATUS; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PERIODONTIUM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AUTOIMMUNITY; EPITHELIAL ATTACHMENT; EXTRACELLULAR MATRIX; FEMALE; FOCAL ADHESIONS; GENE EXPRESSION PROFILING; LACRIMAL APPARATUS; LEUKOCYTES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, MUTANT STRAINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SJOGREN'S SYNDROME; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 80053319862     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7652     Document Type: Article

References (47)

1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. (2007). Ocul Surf. 2007;5(2):75-92.
2. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004;78(3):409-416.
3. Fox RI. Sjogren's syndrome. Lancet. 2005;366(9482):321-331.
4. Delaleu N, Jonsson MV, Appel S, Jonsson R. New concepts in the pathogenesis of Sjögren's syndrome. Rheum Dis Clin North Am. 2008; 34(4):833-845.
5. Hansen A, Lipsky PE, Dörner T. Immunopathogenesis of primary Sjögren's syndrome: implications for disease management and therapy. Curr Opin Rheumatol. 2005;17(5):558-565.
6. Fox PC, Speight PM. Current concepts of autoimmune exocrinopathy: immunologic mechanisms in the salivary pathology of Sjögren's syndrome. Crit Rev Oral Biol Med. 1996;7(2): 144-158.
7. Nguyen CQ, Cha SR, Peck AB. Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Front Biosci. 2007;12:1767-1789.
8. Chiorini JA, Cihakova D, Ouellette CE, Caturegli P. Sjögren syndrome: advances in the pathogenesis from animal models. J Autoimmun. 2009;33(3-4):190-196.
9. Nguyen CQ, Peck AB. Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease. Ocul Surf. 2009;7(1):11-27.
10. Robinson CP, Cornelius J, Bounous DE, Yamamoto H, Humphreys-Beher MG, Peck AB. Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice. Autoimmunity. 1998;27(1):29-44.
11. Cha S, Peck AB, Humphreys-Beher MG. Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. Crit Rev Oral Biol Med. 2002;13(1):5-16.
12. Robinson CP, Yamamoto H, Peck AB, Humphreys-Beher MG. Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice. Clin Immunol Immunopathol. 1996;79(1): 50-59.
13. Humphreys-Beher MG, Peck AB. New concepts for the development of autoimmune exocrinopathy derived from studies with the NOD mouse model. Arch Oral Biol. 1999;44(suppl 1):S21-S25.
14. Cha S, van Blockland SC, Versnel MA, et al. Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy. Exp Clin Immunogenet. 2001;18(3): 143-160.
15. Cha S, Brayer J, Gao J, et al. A dual role for interferon-gamma in the pathogenesis of Sjogren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse. Scand J Immunol. 2004; 60(6):552-565.
16. Killedar SJ, Eckenrode SE, McIndoe RA, et al. Early pathogenic events associated with Sjögren's syndrome (SjS)-like disease of the NOD mouse using microarray analysis. Lab Invest. 2006;86(12): 1243-1260.
17. Nguyen CQ, Sharma A, She JX, McIndoe RA, Peck AB. Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren's syndrome (SJS)-like disease of the C57BL/6. NOD-Aec1Aec2 mouse. Exp Eye Res. 2009; 88(3):398-409.
18. Nguyen CQ, Sharma A, Lee BH, She JX, McIndoe RA, Peck AB. Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6. NOD-Aec1Aec2 mouse. Arthritis Res Ther. 2009; 11(2):R56.
19. Smyth GK, Michaud J, Scott HS. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics. 2005;21(9):2067-2075.
20. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B. 1995;57:289-300.
21. Järveläinen H, Sainio A, Koulu M, Wight TN, Penttinen R. Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev. 2009;61(2):198-223.
22. Brayer J, Lowry J, Cha S, et al. Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy. J Rheumatol. 2000;27(8):1896-1904.
23. Cha S, Nagashima H, Brown VB, Peck AB, Humphreys-Beher MG. Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background. Arthritis Rheum. 2002;46(5): 1390-1398.
24. Barczyk M, Carracedo S, Gullberg D. Integrins Cell Tissue Res. 2010;339(1):269-280.
25. Paidassi H, Tacnet-Delorme P, Arlaud GJ, Frachet P. How phagocytes track down and respond to apoptotic cells. Crit Rev Immunol. 2009;29(2):111-130.
26. Wu Y, Tibrewal N, Birge RB. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol. 2006;16(4):189-197.
27. Steed E, Balda MS, Matter K. Dynamics and functions of tight junctions. Trends Cell Biol. 2010;20(3):142-149.
28. Petit V, Thiery JP. Focal adhesions: structure and dynamics. Biol Cell. 2000;92(7):477-494.
29. Baker OJ. Tight junctions in salivary epithelium. J Biomed Biotechnol. 2010;2010:278948.
30. Brink PR, Valiunas V, Moore L, Birzgalis A, Walcott B. The role of gap junctions in lacrimal acinar cells: the formation of tears. Adv Exp Med Biol. 2002;506(pt A):109-113.
31. Green KJ, Getsios S, Troyanovsky S, Godsel LM. Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol. 2010;2(2):a000125.
32. Meng W, Takeichi M. Adherens junction: molecular architecture and regulation. Cold Spring Harb Perspect Biol. 2009;1(6): a002899.
33. Wang XQ, Frazier WA. The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Mol Biol Cell. 1998;9(4):865-874.
34. Oh ES, Woods A, Couchman JR. Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C. J Biol Chem. 1997;272(13):8133-8136.
35. Rojiani MV, Finlay BB, Gray V, Dedhar S. In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. Biochemistry. 1991;30(41): 9859-9866.
36. Lenter M, Vestweber D. The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly. J Biol Chem. 1994;269(16):12263-12268.
37. Choi Y, Kim S, Lee J, et al. The oligomeric status of syndecan-4 regulates syndecan-4 interaction with alpha-actinin. Eur J Cell Biol. 2008;87(10):807-815.
38. Ballestrem C, Erez N, Kirchner J, Kam Z, Bershadsky A, Geiger B. Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci. 2006;119(pt 5):866-875.
39. Naik UP, Patel PM, Parise LV. Identification of a novel calciumbinding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem. 1997;272(8):4651-4654.
40. Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM. Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol. 2010;188(6):877-890.
41. Rottner K, Behrendt B, Small JV, Wehland J. VASP dynamics during lamellipodia protrusion. Nat Cell Biol. 1999;1(5):321-322.
42. Ewert P, Aguilera S, Alliende C, et al. Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure. Arthritis Rheum. 2010;62(5):1280-1289.
43. Borradori L, Sonnenberg A. Hemidesmosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol. 1996;8(5):647-656.
44. Sondermann H, Dogic D, Pesch M, Aumailley M. Targeting of cytoskeletal linker proteins to focal adhesion complexes is reduced in fibroblasts adhering to laminin-1 when compared to fibronectin. Cell Adhes Commun. 1999;7(1):43-56.
45. Yamada KM, Miyamoto S. Integrin transmembrane signaling and cytoskeletal control. Curr Opin Cell Biol. 1995;7(5):681-689.
46. Miyamoto S, Teramoto H, Coso OA, et al. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol. 1995;131(3):791-805.
47. Danen EH, Lafrenie RM, Miyamoto S, Yamada KM. Integrin signaling: cytoskeletal complexes, MAP kinase activation, and regulation of gene expression. Cell Adhes Commun. 1998;6(2-3):217-224.