Sjögren syndrome: Advances in the pathogenesis from animal models

Journal of Autoimmunity

Volumn 33, Issue 3-4, 2009, Pages 190-196

  Chiorini, J A ^a   Cihakova, D ^b   Ouellette, C E ^c   Caturegli, P ^b,c  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Autoimmunity; Mouse models; Sj gren syndrome

Indexed keywords

AUTOANTIBODY; B CELL ACTIVATING FACTOR; CARBONATE DEHYDRATASE II; INHIBITOR OF DIFFERENTIATION 3; INTERLEUKIN 12; INTERLEUKIN 14; PHOSPHATIDYLINOSITOL 3 KINASE; RO ANTIBODY;

ARTHROPATHY; ARTICLE; AUTOIMMUNITY; CARCINOGENESIS; CLINICAL FEATURE; DISEASE MARKER; DISEASE MODEL; EXPERIMENTAL ANIMAL; FATIGUE; GENE OVEREXPRESSION; HYPOTHYROIDISM; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; KNOCKOUT MOUSE; LUNG DISEASE; LYMPHOMA; MUSCLE DISEASE; NEW ZEALAND BLACK MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PREGNANCY COMPLICATION; PRIORITY JOURNAL; SJOEGREN SYNDROME; SKIN DEFECT; TRANSGENIC MOUSE; XEROPHTHALMIA; XEROSTOMIA;

ANIMALS; AUTOANTIBODIES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INTERLEUKIN-12; INTERLEUKINS; LYMPHOMA; MICE; MICE, MUTANT STRAINS; PREGNANCY; PREGNANCY COMPLICATIONS; SJOGREN'S SYNDROME;

EID: 71649092051     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2009.09.009     Document Type: Article

References (81)

1. Fox R.I. Sjogren's syndrome. Lancet 366 (2005) 321-331
2. Vitali C., Bombardieri S., Jonsson R., Moutsopoulos H.M., Alexander E.L., Carsons S.E., et al. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis 61 (2002) 554-558
3. Morbini P., Manzo A., Caporali R., Epis O., Villa C., Tinelli C., et al. Multilevel examination of minor salivary gland biopsy for Sjogren's syndrome significantly improves diagnostic performance of AECG classification criteria. Arthritis Res Ther 7 (2005) R343-R348
4. Galvez J., Saiz E., Lopez P., Pina M.F., Carrillo A., Nieto A., et al. Diagnostic evaluation and classification criteria in Sjogren's Syndrome. Jt Bone Spine 76 (2009) 44-49
5. Venables P.J. Sjogren's syndrome. Best Pract Res Clin Rheumatol 18 (2004) 313-329
6. Delaleu N., Jonsson M.V., Appel S., and Jonsson R. New concepts in the pathogenesis of Sjogren's syndrome. Rheum Dis Clin North Am 34 (2008) 833-845 vii
7. Gondran G., Fauchais A., Lambert M., Ly K., Launay D., Queyrel V., et al. Primary Sjogren's syndrome in men. Scand J Rheumatol 37 (2008) 300-305
8. Fox R.I., and Liu A.Y. Sjogren's syndrome in dermatology. Clin Dermatol 24 (2006) 393-413
9. Ramos-Casals M., Brito-Zeron P., and Font J. The overlap of Sjogren's syndrome with other systemic autoimmune diseases. Semin Arthritis Rheum 36 (2007) 246-255
10. Tzioufas A.G., and Voulgarelis M. Update on Sjogren's syndrome autoimmune epithelitis: from classification to increased neoplasias. Best Pract Res Clin Rheumatol 21 (2007) 989-1010
11. Wright S.A., Convery R.P., and Liggett N. Pulmonary involvement in Sjogren's syndrome. Rheumatology (Oxford) 42 (2003) 697-698
12. Davidson B.K., Kelly C.A., and Griffiths I.D. Ten year follow up of pulmonary function in patients with primary Sjogren's syndrome. Ann Rheum Dis 59 (2000) 709-712
13. Taouli B., Brauner M.W., Mourey I., Lemouchi D., and Grenier P.A. Thin-section chest CT findings of primary Sjogren's syndrome: correlation with pulmonary function. Eur Radiol 12 (2002) 1504-1511
14. Constantopoulos S.H., Papadimitriou C.S., and Moutsopoulos H.M. Respiratory manifestations in primary Sjogren's syndrome. A clinical, functional, and histologic study. Chest 88 (1985) 226-229
15. Newball H.H., and Brahim S.A. Chronic obstructive airway disease in patients with Sjogren's syndrome. Am Rev Respir Dis 115 (1977) 295-304
16. Papiris S.A., Maniati M., Constantopoulos S.H., Roussos C., Moutsopoulos H.M., and Skopouli F.N. Lung involvement in primary Sjogren's syndrome is mainly related to the small airway disease. Ann Rheum Dis 58 (1999) 61-64
17. Gudbjornsson B., Hedenstrom H., Stalenheim G., and Hallgren R. Bronchial hyperresponsiveness to methacholine in patients with primary Sjogren's syndrome. Ann Rheum Dis 50 (1991) 36-40
18. Potena A., La Corte R., Fabbri L.M., Papi A., Trotta F., and Ciaccia A. Increased bronchial responsiveness in primary and secondary Sjogren's syndrome. Eur Respir J 3 (1990) 548-553
19. Battista G., Zompatori M., Poletti V., and Canini R. Thoracic manifestations of the less common collagen diseases. A pictorial essay. Radiol Med (Torino) 106 (2003) 445-451 quiz 452-443
20. Koyama M., Johkoh T., Honda O., Mihara N., Kozuka T., Tomiyama N., et al. Pulmonary involvement in primary Sjogren's syndrome: spectrum of pulmonary abnormalities and computed tomography findings in 60 patients. J Thorac Imaging 16 (2001) 290-296
21. Constantopoulos S.H., Tsianos E.V., and Moutsopoulos H.M. Pulmonary and gastrointestinal manifestations of Sjogren's syndrome. Rheum Dis Clin North Am 18 (1992) 617-635
22. Skalova S., Minxova L., and Slezak R. Hypokalaemic Paralysis Revealing Sjogren's syndrome in a 16-Year old Girl. Ghana Med J 42 (2008) 124-128
23. Porola P., Virkki L., Przybyla B.D., Laine M., Patterson T.A., Pihakari A., et al. Androgen deficiency and defective intracrine processing of dehydroepiandrosterone in salivary glands in Sjogren's syndrome. J Rheumatol 35 (2008) 2229-2235
24. Kaplan H.S., and Smithers D.W. Auto-immunity in man and homologous disease in mice in relation to the malignant lymphomas. Lancet 2 (1959) 1-4
25. Zintzaras E., Voulgarelis M., and Moutsopoulos H.M. The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med 165 (2005) 2337-2344
26. Mackay I.R., and Rose N.R. Autoimmunity and lymphoma: tribulations of B cells. Nat Immunol 2 (2001) 793-795
27. Kassan S.S., Thomas T.L., Moutsopoulos H.M., Hoover R., Kimberly R.P., Budman D.R., et al. Increased risk of lymphoma in sicca syndrome. Ann Intern Med 89 (1978) 888-892
28. Miklos J.A., Swerdlow S.H., and Bahler D.W. Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features. Blood 95 (2000) 3878-3884
29. Ambrosetti A., Zanotti R., Pattaro C., Lenzi L., Chilosi M., Caramaschi P., et al. Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection. Br J Haematol 126 (2004) 43-49
30. Anderson L.G., and Talal N. The spectrum of benign to malignant lymphoproliferation in Sjogren's syndrome. Clin Exp Immunol 10 (1972) 199-221
31. Skopouli F.N., Dafni U., Ioannidis J.P., and Moutsopoulos H.M. Clinical evolution, and morbidity and mortality of primary Sjogren's syndrome. Semin Arthritis Rheum 29 (2000) 296-304
32. Voulgarelis M., and Moutsopoulos H.M. Mucosa-associated lymphoid tissue lymphoma in Sjogren's syndrome: risks, management, and prognosis. Rheum Dis Clin North Am 34 (2008) 921-933 [viii]
33. Buyon J.P., Clancy R.M., and Friedman D.M. Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside. Nat Clin Pract Rheumatol 5 (2009) 139-148
34. Moak J.P., Barron K.S., Hougen T.J., Wiles H.B., Balaji S., Sreeram N., et al. Congenital heart block: development of late-onset cardiomyopathy, a previously underappreciated sequela. J Am Coll Cardiol 37 (2001) 238-242
35. Eronen M., Siren M.K., Ekblad H., Tikanoja T., Julkunen H., and Paavilainen T. Short- and long-term outcome of children with congenital complete heart block diagnosed in utero or as a newborn. Pediatrics 106 (2000) 86-91
36. Locht H., Pelck R., and Manthorpe R. Diagnostic and prognostic significance of measuring antibodies to alpha-fodrin compared to anti-Ro-52, anti-Ro-60, and anti-La in primary Sjogren's syndrome. J Rheumatol 35 (2008) 845-849
37. Koo N.Y., Li J., Hwang S.M., Choi S.Y., Lee S.J., Oh S.B., et al. Functional epitope of muscarinic type 3 receptor which interacts with autoantibodies from Sjogren's syndrome patients. Rheumatology (Oxford) 47 (2008) 828-833
38. Lee B.H., Tudares M.A., and Nguyen C.Q. Sjogren's syndrome: an old tale with a new twist. Arch Immunol Ther Exp (Warsz) 57 (2009) 57-66
39. Jonsson R., Tarkowski A., Backman K., and Klareskog L. Immunohistochemical characterization of sialadenitis in NZB X NZW F1 mice. Clin Immunol Immunopathol 42 (1987) 93-101
40. Deshmukh U.S., Nandula S.R., Thimmalapura P.R., Scindia Y.M., and Bagavant H. Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function. J Oral Pathol Med 38 (2009) 42-47
41. Wen L., Ley R.E., Volchkov P.Y., Stranges P.B., Avanesyan L., Stonebraker A.C., et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455 (2008) 1109-1113
42. Lodde B.M., Mineshiba F., Kok M.R., Wang J., Zheng C., Schmidt M., et al. NOD mouse model for Sjogren's syndrome: lack of longitudinal stability. Oral Dis 12 (2006) 566-572
43. Brayer J., Lowry J., Cha S., Robinson C.P., Yamachika S., Peck A.B., et al. Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjogren's syndrome-like autoimmune exocrinopathy. J Rheumatol 27 (2000) 1896-1904
44. Nguyen C., Singson E., Kim J.Y., Cornelius J.G., Attia R., Doyle M.E., et al. Sjogren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus. Scand J Immunol 64 (2006) 295-307
45. Cha S., Nagashima H., Brown V.B., Peck A.B., and Humphreys-Beher M.G. Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjogren's syndrome) on a healthy murine background. Arthritis Rheum 46 (2002) 1390-1398
46. Kong L., Robinson C.P., Peck A.B., Vela-Roch N., Sakata K.M., Dang H., et al. Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice. Clin Exp Rheumatol 16 (1998) 675-681
47. Podolin P.L., Pressey A., DeLarato N.H., Fischer P.A., Peterson L.B., and Wicker L.S. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178 (1993) 793-803
48. Rasooly L., Burek C.L., and Rose N.R. Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. Clin Immunol Immunopathol 81 (1996) 287-292
49. Li H., Dai M., and Zhuang Y. A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity 21 (2004) 551-560
50. Sellam J., Miceli-Richard C., Gottenberg J.E., Proust A., Ittah M., Lavie F., et al. Is Inhibitor of differentiation 3 involved in human primary Sjogren's syndrome?. Rheumatology (Oxford) 47 (2008) 437-441
51. Nakamura H., Kawakami A., Iwamoto N., Ida H., Koji T., and Eguchi K. Rapid and significant induction of TRAIL-mediated type II cells in apoptosis of primary salivary epithelial cells in primary Sjogren's syndrome. Apoptosis 13 (2008) 1322-1330
52. Oak J.S., Deane J.A., Kharas M.G., Luo J., Lane T.E., Cantley L.C., et al. Sjogren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc Natl Acad Sci U S A 103 (2006) 16882-16887
53. Groom J., Kalled S.L., Cutler A.H., Olson C., Woodcock S.A., Schneider P., et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J Clin Invest 109 (2002) 59-68
54. Oh-Hora M., Yamashita M., Hogan P.G., Sharma S., Lamperti E., Chung W., et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol 9 (2008) 432-443
55. Scofield R.H., Asfa S., Obeso D., Jonsson R., and Kurien B.T. Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sjogren's syndrome. J Immunol 175 (2005) 8409-8414
56. Nguyen H.V., Shull G.E., and Melvin J.E. Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. Pt 1. J Physiol 523 (2000) 139-146
57. Dite P., Novotny I., Trna J., and Sevcikova A. Autoimmune pancreatitis. Best Pract Res Clin Gastroenterol 22 (2008) 131-143
58. Caccavo D., Afeltra A., Rigon A., Vadacca M., Zobel B.B., Zennaro D., et al. Antibodies to carbonic anhydrase in patients with connective tissue diseases: relationship with lung involvement. Int J Immunopathol Pharmacol 21 (2008) 659-667
59. Nishimori I., Bratanova T., Toshkov I., Caffrey T., Mogaki M., Shibata Y., et al. Induction of experimental autoimmune sialoadenitis by immunization of PL/J mice with carbonic anhydrase II. J Immunol 154 (1995) 4865-4873
60. Nishimori I., Miyaji E., Morimoto K., Kohsaki T., Okamoto N., and Onishi S. Diminished cellular immune response to carbonic anhydrase II in patients with Sjogren's syndrome and idiopathic chronic pancreatitis. Jop 5 (2004) 186-192
61. Dawson L.J., Fox P.C., and Smith P.M. Sjogrens syndrome-the non-apoptotic model of glandular hypofunction. Rheumatology (Oxford) 45 (2006) 792-798
62. Meehan S., Wu A.J., Kang E.C., Sakai T., and Ambudkar I.S. Interferon-gamma induces a decrease in the intracellular calcium pump in a human salivary gland cell line. Am J Physiol 273 (1997) C2030-C2036
63. Jonsson M.V., Delaleu N., Brokstad K.A., Berggreen E., and Skarstein K. Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland. Arthritis Rheum 54 (2006) 2300-2305
64. Shen L., Suresh L., Li H., Zhang C., Kumar V., Pankewycz O., et al. IL-14 alpha, the nexus for primary Sjogren's disease in mice and humans. Clin Immunol 130 (2009) 304-312
65. Shen L., Zhang C., Wang T., Brooks S., Ford R.J., Lin-Lee Y.C., et al. Development of autoimmunity in IL-14alpha-transgenic mice. J Immunol 177 (2006) 5676-5686
66. Kimura-Shimmyo A., Kashiwamura S., Ueda H., Ikeda T., Kanno S., Akira S., et al. Cytokine-induced injury of the lacrimal and salivary glands. J Immunother 25 Suppl 1 (2002) S42-S51
67. Ohyama Y., Nakamura S., Matsuzaki G., Shinohara M., Hiroki A., Fujimura T., et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 39 (1996) 1376-1384
68. Kimura H., Tzou S.C., Rocchi R., Kimura M., Suzuki K., Parlow A.F., et al. Interleukin (IL)-12-driven primary hypothyroidism: the contrasting roles of two Th1 cytokines (IL-12 and interferon-gamma). Endocrinology 146 (2005) 3642-3651
69. McGrath-Morrow S., Laube B., Tzou S.C., Cho C., Cleary J., Kimura H., et al. IL-12 overexpression in mice as a model for Sjogren lung disease. Am J Physiol Lung Cell Mol Physiol 291 (2006) L837-L846
70. Mackay I.R., Leskovsek N.V., and Rose N.R. Cell damage and autoimmunity: a critical appraisal. J Autoimmun 30 (2008) 5-11
71. Eaton W.W., Rose N.R., Kalaydjian A., Pedersen M.G., and Mortensen P.B. Epidemiology of autoimmune diseases in Denmark. J Autoimmun 29 (2007) 1-9
72. Shoenfeld Y., Selmi C., Zimlichman E., and Gershwin M.E. The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity. J Autoimmmun 31 (2008) 325-330
73. Burek C.L., and Rose N.R. Autoimmune thyroiditis and ROS. Autoimmun Rev 7 (2008) 530-537
74. Caturegli P., Kimura H., Rocchi R., and Rose N.R. Autoimmune thyroid diseases. Curr Opin Rheumatol 19 (2007) 44-48
75. Dighiero G., and Rose N.R. Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity. Immunol Today 20 (1999) 423-428
76. Ligons D.L., Guler M.L., Li H.S., and Rose N.R. A locus on chromosome 1 promotes susceptibility of experimental autoimmune myocarditis and lymphocyte cell death. Clin Immunol 130 (2009) 74-82
77. Rose N.R., and Cihakova D. Cardiomyopathies. Autoimmunity 37 (2004) 347-350
78. Li H.S., Ligons D.L., and Rose N.R. Genetic complexity of autoimmune myocarditis. Autoimmun Rev 7 (2008) 168-173
79. Whittingham S., Rowley M.J., and Gershwin M.E. A tribute to an outstanding immunologist - Ian Reay Mackay. J Autoimmun 31 (2008) 197-200
80. Gershwin M.E. Bone marrow transplantation, refractory autoimmunity and the contributions of Susumu Ikehara. J Autoimmun 30 (2008) 105-107
81. Blank M., and Gershwin M.E. Autoimmunity: from the mosaic to the kaleidoscope. J Autoimmun 30 (2008) 1-4