CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells

DNA Repair

Volumn 10, Issue 10, 2011, Pages 1000-1001

  Choi, Serah ^a   Toledo, Luis I ^b   Fernandez Capetillo, Oscar ^a   Bakkenist, Christopher J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Structural Biology and Biocomputing Programme   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; ATR PROTEIN; CGK 733; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DEOXYRIBONUCLEASE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

CANCER CELL CULTURE; CELL STRAIN H460; CONTROLLED STUDY; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; GAMMA RADIATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LETTER; LUNG CANCER; PHOTOSYNTHETIC PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ULTRAVIOLET RADIATION;

BENZENEACETAMIDES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; HUMANS; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; THIOUREA; TUMOR SUPPRESSOR PROTEINS; ULTRAVIOLET RAYS;

EID: 80053304911     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2011.07.013     Document Type: Letter

References (15)

1. Won J., Kim M., Kim N., Ahn J.H., Lee W.G., Kim S.S., Chang K.Y., Yi Y.W., Kim T.K. Small molecule-based reversible reprogramming of cellular lifespan. Nat. Chem. Biol. 2006, 2:369-374.
2. Won J., Kim M., Kim N., Ahn J.H., Lee W.G., Kim S.S., Chang K.Y., Yi Y.W. Retraction: small molecule-based reversible reprogramming of cellular lifespan. Nat. Chem. Biol. 2008, 4:431.
3. Cruet-Hennequart S., Glynn M.T., Murillo L.S., Coyne S., Carty M.P. Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin. DNA Repair (Amst.) 2008, 7:582-596.
4. Shrivastav M., Miller C.A., De Haro L.P., Durant S.T., Chen B.P., Chen D.J., Nickoloff J.A. DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst.) 2009, 8:920-929.
5. Alao J.P., Sunnerhagen P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat. Oncol. 2009, 4:51.
6. Takahashi A., Mori E., Su X., Nakagawa Y., Okamoto N., Uemura H., Kondo N., Noda T., Toki A., Ejima Y., Chen D.J., Ohnishi K., Ohnishi T. ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating. J. Radiat. Res. (Tokyo) 2010, 51:417-422.
7. Cuffe S., Dowling C.M., Claffey J., Pampillón C., Hogan M., Fitzpatrick J.M., Carty M.P., Tacke M., Watson R.W. Effects of titanocene dichloride derivatives on prostate cancer cells, specifically DNA damage-induced apoptosis. Prostate 2011, 71:111-124.
8. Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506.
9. Matsuoka S., Huang M., Elledge S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998, 282:1893-1897.
10. Hickson I., Zhao Y., Richardson C.J., Green S.J., Martin N.M., Orr A.I., Reaper P.M., Jackson S.P., Curtin N.J., Smith G.C. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004, 64:9152-9159.
11. Golding S.E., Rosenberg E., Valerie N., Hussaini I., Frigerio M., Cockcroft X.F., Chong W.Y., Hummersone M., Rigoreau L., Menear K.A., O'Connor M.J., Povirk L.F., van Meter T., Valerie K. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol. Cancer Ther. 2009, 8:2894-2902.
12. White J.S., Choi S., Bakkenist C.J. Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. Cell Cycle 2008, 7:277-1284.
13. White J.S., Choi S., Bakkenist C.J. Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. Sci. Signal. 2010, 3:ra44.
14. Zhao H., Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 2001, 21:4129-4139.
15. Toledo L.I., Murga M., Zur R., Soria R., Rodriguez A., Martinez S., Oyarzabal J., Pastor J., Bischoff J.R., Fernandez-Capetillo O. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat. Struct. Mol. Biol. 2011, 18:721-727.