Effect and distribution of contrast medium after injection into the anterior suprachoroidal space in ex vivo eyes

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 8, 2011, Pages 5730-5736

  Seiler, Gabriela S ^a   Salmon, Jacklyn H ^a   Mantuo, Rebecca ^a   Feingold, Steven ^a   Dayton, Paul A ^a   Gilger, Brian C ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRAST MEDIUM; LATEX;

ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ARTICLE; CHOROID; DOG; DRUG DELIVERY SYSTEM; DRUG INJECTION VOLUME; EX VIVO STUDY; INJECTION SITE; INTRAOCULAR PRESSURE; MICROBUBBLE; NONHUMAN; POSTERIOR EYE SEGMENT; PRIORITY JOURNAL; RETINA; SWINE; ULTRASOUND; AGE; ANIMAL; ECHOGRAPHY; IN VITRO STUDY; INTRAOCULAR DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; THREE DIMENSIONAL IMAGING;

AGE FACTORS; ANIMALS; ANTERIOR CHAMBER; CHOROID; CONTRAST MEDIA; DOGS; DRUG DELIVERY SYSTEMS; IMAGING, THREE-DIMENSIONAL; INJECTIONS, INTRAOCULAR; LATEX; MICROBUBBLES; POSTERIOR EYE SEGMENT; RETINA; SWINE;

EID: 80053303920     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7525     Document Type: Article

References (31)

1. Edelhauser H, Rowe-Rendleman C, Robinson M, et al. Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Invest Ophthalmol Vis Sci. 2010;51:5403-5420.
2. Maurice DM. Drug delivery to the posterior segment from drops. Surv Ophthalmol. 2002;47(suppl 1):S41-S52.
3. Hughes P, Olejnik O, Chang-Lin J, Wilson C. Topical and systemic drug delivery to the posterior segments. Adv Drug Deliv Rev. 2005;57:2010-2032.
4. Lee SS, Hughes PM, Robinson MR. Recent advances in drug delivery systems for treating ocular complications of systemic diseases. Curr Opin Ophthalmol. 2009;20:511-519.
5. Kim H, Csaky KG, Gravlin L, et al. Safety and pharmacokinetics of a preservative-free triamcinolone acetonide formulation for intravitreal administration. Retina. 2006;26:523-530.
6. Kim S, Galban C, Lutz R, et al. Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging. Invest Ophthalmol Vis Sci. 2007;48:808-814.
7. Kim SH, Lutz RJ, Wang NS, Robinson MR. Transport barriers in transscleral drug delivery for retinal diseases. Ophthalmic Res. 2007;39:244-254.
8. Sampat KM, Garg SJ. Complications of intravitreal injections. Curr Opin Ophthalmol. 2010;21:178-183.
9. Shima C, Sakaguchi H, Gomi F, et al. Complications in patients after intravitreal injection of bevacizumab. Acta Ophthalmol. 2008;86:372-376.
10. Callanan DG, Jaffe GJ, Martin DF, Pearson PA, Comstock TL. Treatment of posterior uveitis with a fluocinolone acetonide implant: three-year clinical trial results. Arch Ophthalmol. 2008;126:1191-1201.
11. Krohn J, Bertelsen T. Corrosion casts of the suprachoroidal space and uveoscleral drainage routes in the human eye. Acta Ophthalmol Scand. 1997;75:32-35.
12. Einmahl S, Savoldelli M, D'Hermies F, Tabatabay C, Gurny R, Behar-Cohen F. Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye. Invest Ophthalmol Vis Sci. 2002;43:1533-1539.
13. Olsen TW, Feng X, Wabner K, et al. Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment. Am J Ophthalmol. 2006;142:777-787.
14. Hou J, Tao Y, Jiang Y, Wang K. In vivo and in vitro study of suprachoroidal fibrin glue. Jpn J Ophthalmol. 2009;53:640-647.
15. Olsen TW, Feng X, Wabner K, et al. Pharmacokinetics of pars plana intravitreal injections versus microcannula suprachoroidal injections of bevacizumab in a porcine model. Invest Ophthalmol Vis Sci. 2011;52:4749-4756.
16. Gilger BC, Salmon JH, Wilkie DA, et al. A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis. Invest Ophthalmol Vis Sci. 2006;47:2596-2605.
17. Patel S, Lin A, Edelhauser HF, Prausnitz M. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm Res. 2011;28:166-176.
18. Gilger BC, Reeves KA, Salmon JH. Ocular parameters related to drug delivery in the canine and equine eye: aqueous and vitreous humor volume and scleral surface area and thickness. Vet Ophthalmol. 2005;8:265-269.
19. Shafiee A, McIntire GL, Sidebotham LC, Ward KW. Experimental determination and allometric prediction of vitreous volume, and retina and lens weights in Gottingen minipigs. Vet Ophthalmol. 2008;11:193-196.
20. Bui BV, Edmunds B, Cioffi GA, Fortune B. The gradient of retinal functional changes during acute intraocular pressure elevation. Invest Ophthalmol Vis Sci. 2005;46:202-213.
21. Oz O, Gurelik G, Akyurek N, Cinel L, Hondur A. A short duration transient ischemia induces apoptosis in retinal layers: an experimental study in rabbits. Eur J Ophthalmol. 2005;15:233-238.
22. Patel SR, Lin AS, Edelhauser HF, Prausnitz MR. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm Res. 2011;28:166-176.
23. Mittl RN. Perfluorocarbon gases in the suprachoroidal space of rabbit eyes. Graefes Arch Clin Exp Ophthalmol. 1990;228:589-593.
24. Mittl RN, Tiwari R. Suprachoroidal injection of sodium hyaluronate as an 'internal' buckling procedure. Ophthalmic Res. 1987;19: 255-260.
25. Rychak JJ, Graba J, Cheung AM, et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging. 2007;6:289-296.
26. Klibanov AL. Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest Radiol. 2006;41:354-362.
27. Burke CW, Price RJ. Contrast ultrasound targeted treatment of gliomas in mice via drug-bearing nanoparticle delivery and microvascular ablation. J Vis Exp. 2010;46: pii: 2145. doi: 10.3791/2145.
28. Uesugi Y, Kawata H, Jo J, Saito Y, Tabata Y. An ultrasoundresponsive nano delivery system of tissue-type plasminogen activator for thrombolytic therapy. J Control Release. 2010;147:269-277.
29. Hynynen K. Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain. Expert Opin Drug Deliv. 2007;4:27-35.
30. Lum AF, Borden MA, Dayton PA, Kruse DE, Simon SI, Ferrara KW. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J Control Release. 2006;111:128-134.
31. Feingold S, Gessner R, Guracar IM, Dayton PA. Quantitative volumetric perfusion mapping of the microvasculature using contrast ultrasound. Invest Radiol. 2010;45:669-674.