Proton delivery to ferryl heme in a heme peroxidase: Enzymatic use of the grotthuss mechanism

Journal of the American Chemical Society

Volumn 133, Issue 39, 2011, Pages 15376-15383

  Efimov, Igor ^a   Badyal, Sandip K ^a   Metcalfe, Clive L ^a   MacDonald, Isabel ^a   Gumiero, Andrea ^a   Raven, Emma Lloyd ^a   Moody, Peter C E ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE RESIDUE; ASCORBATE PEROXIDASE; BOUND SOLVENTS; COMPOUND I; DUAL ROLE; ENZYME OXIDATION; GROTTHUSS MECHANISM; HEME ENZYME; HEME PEROXIDASE; INVENTORY DATA; KINETIC CONSTANT; NONLINEAR DEPENDENCE; PROTON DELIVERY; SIDE-CHAINS; SOLVENT KINETIC ISOTOPE EFFECTS; SUBSEQUENT REDUCTION; TRANSITION STATE; WILD TYPES; WILD-TYPE ENZYMES; X-RAY STRUCTURE;

AMINO ACIDS; DEUTERIUM; ENZYMES; PROTON TRANSFER; SOLVENTS;

PORPHYRINS;

AMINO ACID; ARGININE; ASCORBATE PEROXIDASE; ASCORBIC ACID; DEUTERIUM; HEME; HEME PEROXIDASE; HYDROGEN PEROXIDE; OXYGEN; PEROXIDASE; PROTON; UNCLASSIFIED DRUG;

ARTICLE; ENZYME METABOLISM; GROSS BUTLER SWAIN KRESGE THEORY; KINETICS; PROTON TRANSPORT; SOLVENT KINETIC ISOTOPE EFFECT; STEADY STATE; STRUCTURE ANALYSIS; THEORY; WILD TYPE; X RAY;

ASCORBATE PEROXIDASES; CRYSTALLOGRAPHY, X-RAY; HEME; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTONS; SOYBEANS;

EID: 80053302931     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2007017     Document Type: Article

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