Biogenesis of the unique 4′,5′-dehydronucleoside of the uridyl peptide antibiotic pacidamycin

Journal of the American Chemical Society

Volumn 133, Issue 39, 2011, Pages 15288-15291

  Ragab, Amany E ^a,b   Grüschow, Sabine ^a   Tromans, Daniel R ^a   Goss, Rebecca J M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b TANTA UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

KEY ENZYMES; PEPTIDE ANTIBIOTICS; PEPTIDOGLYCANS; PHARMACOPHORES; TRANSLOCASES;

ALDEHYDES; BIOCHEMISTRY; BIOMOLECULES; BIOSYNTHESIS; PEPTIDES;

ANTIBIOTICS;

ALDEHYDE; NUCLEOSIDE; PACIDAMYCIN; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; URIDINE;

ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; DRUG TRANSFORMATION; NONHUMAN; OXIDATION; STREPTOMYCES COERULEORUBIDUS; STREPTOMYCETACEAE;

ANTI-BACTERIAL AGENTS; MULTIGENE FAMILY; PEPTIDES; STREPTOMYCES; URIDINE;

EID: 80053302413     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja206163j     Document Type: Article

References (17)

1. Winn, M.; Goss, R. J. M.; Kimura, K.; Bugg, T. D. H. Nat. Prod. Rep. 2010, 27, 279
2. Isono, K. J. Antibiot. 1988, 41, 1711
3. Beringer, M.; Rodnina, M. V. Mol. Cell 2007, 26, 311
4. Lipovsek, D.; Pluckthun, A. J. Immunol. Methods 2004, 290, 51
5. Rubio, M. A.; Espinosa, J. C.; Tercero, J. A.; Jimenez, A. FEBS Lett. 1998, 437, 197
6. Ginj, C.; Ruegger, H.; Amrhein, N.; Macheroux, P. ChemBioChem 2005, 6, 1974
7. Chen, W. Q.; Huang, T. T.; He, X. Y.; Meng, Q. Q.; You, D. L.; Bai, L. Q.; Li, J. L.; Wu, M. X.; Li, R.; Xie, Z. J.; Zhou, H. C.; Zhou, X. F.; Tan, H. R.; Deng, Z. X. J. Biol. Chem. 2009, 284, 10627
8. Yang, Z. Y.; Chi, X. L.; Funabashi, M.; Baba, S.; Nonaka, K.; Pahari, P.; Unrine, J.; Jacobsen, J. M.; Elliott, G. I.; Rohr, J.; Van Lanen, S. G. J. Biol. Chem. 2011, 286, 7885
9. Rackham, E. J.; Grüschow, S.; Ragab, A. E.; Dickens, S.; Goss, R. J. M. ChemBioChem 2010, 11, 1700
10. Hausinger, R. P. Crit. Rev. Biochem. Mol. Biol. 2004, 39, 21
11. Dunwell, J. M.; Culham, A.; Carter, C. E.; Sosa-Aguirre, C. R.; Goodenough, P. W. Trends Biochem. Sci. 2001, 26, 740
12. Zhang, W.; Ntai, I.; Bolla, M. L.; Malcomson, S. J.; Kahne, D.; Kelleher, N. L.; Walsh, C. T. J. Am. Chem. Soc. 2011, 133, 5240
13. Heuts, D.; Scrutton, N. S.; McIntire, W. S.; Fraaije, M. W. FEBS J. 2009, 276, 3405
14. Vedavathi, M.; Girish, K. S.; Kumar, M. K. Biochemistry (Moscow) 2006, 71, S105
15. Gentle, C. A.; Bugg, T. D. H. J. Chem. Soc., Perkin Trans. 1 1999, 1279
16. Grüschow, S.; Rackham, E. J.; Elkins, B.; Newill, P. L. A.; Hill, L. M.; Goss, R. J. M. ChemBioChem 2009, 10, 355
17. Ragab, A. E.; Grüschow, S.; Rackham, E. J.; Goss, R. J. M. Org. Biomol. Chem. 2010, 8, 3128