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Volumn 16, Issue 9, 2011, Pages 7634-7648

A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway

Author keywords

Airway hyper responsiveness; Airway inflammation; Asthma; Ginkgolide B; MAPK

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; GINKGOLIDE; GINKGOLIDE B; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 5; LACTONE; MITOGEN ACTIVATED PROTEIN KINASE; OVALBUMIN;

EID: 80053224180     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16097634     Document Type: Article
Times cited : (65)

References (36)
  • 1
    • 34648820354 scopus 로고    scopus 로고
    • The allergic cascade: Review of the most important molecules in the asthmatic lung
    • DOI 10.1016/j.imlet.2007.07.010, PII S0165247807001575
    • Bloemen, K.; Verstraelen, S.; van Den Heuvel, R.; Witters, H.; Nelissen, I.; Schoeters, G. The allergic cascade: Review of the most important molecules in the asthmatic lung. Immunol. Lett. 2007, 113, 6-18. (Pubitemid 47464616)
    • (2007) Immunology Letters , vol.113 , Issue.1 , pp. 6-18
    • Bloemen, K.1    Verstraelen, S.2    Van Den Heuvel, R.3    Witters, H.4    Nelissen, I.5    Schoeters, G.6
  • 2
    • 0036882155 scopus 로고    scopus 로고
    • H2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis
    • DOI 10.1067/mai.2002.129698
    • Brightling, C.E.; Symon, F.A.; Birring, S.S.; Bradding, P.; Pavord, I.D.; Wardlaw A.J. TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J. Allergy Clin. Immunol. 2002, 110, 899-905. (Pubitemid 36005878)
    • (2002) Journal of Allergy and Clinical Immunology , vol.110 , Issue.6 , pp. 899-905
    • Brightling, C.E.1    Symon, F.A.2    Birring, S.S.3    Bradding, P.4    Pavord, I.D.5    Wardlaw, A.J.6
  • 3
    • 0026643596 scopus 로고
    • Interleukin-5, eosinophils, and disease
    • Sanderson, C.J. Interleukin-5, eosinophils, and disease. Blood 1992, 79, 3101-3109.
    • (1992) Blood , vol.79 , pp. 3101-3109
    • Sanderson, C.J.1
  • 8
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signaling pathways: An evolving web
    • DOI 10.1067/mai.2003.1333
    • Hershey, G.K. IL-13 receptors and signaling pathways: An evolving web. J. Allergy Clin. Immunol. 2003, 111, 677-690. (Pubitemid 36470232)
    • (2003) Journal of Allergy and Clinical Immunology , vol.111 , Issue.4 , pp. 677-690
    • Khurana Hershey, G.K.1
  • 9
    • 0034101139 scopus 로고    scopus 로고
    • Alkyl and alkoxycarbonyl derivatives of ginkgolide B: Synthesis and biological evaluation of PAF inhibitory activity
    • DOI 10.1016/S0968-0896(00)00085-7, PII S0968089600000857
    • Hu, L.; Chen, Z.; Xie, Y.; Jiang, Y.; Zhen, H. Alkyl and alkoxycarbonyl derivatives of ginkgolide B: Synthesis and biological evaluation of PAF inhibitory activity. Bioorg. Med. Chem. 2000, 822, 1515-1521. (Pubitemid 30398470)
    • (2000) Bioorganic and Medicinal Chemistry , vol.8 , Issue.6 , pp. 1515-1521
    • Hu, L.1    Chen, Z.2    Xie, Y.3    Jiang, Y.4    Zhen, H.5
  • 10
    • 69149098568 scopus 로고    scopus 로고
    • Ginkgolide B Induces Apoptosis via Activation of JNK and p21-Activated Protein Kinase 2 in Mouse Embryonic Stem Cells
    • Hsuuw, Y.D.; Kuo, T.F.; Lee, K.H.; Liu, Y.C.; Huang, Y.T.; Lai, C.Y.; Chan, W.H. Ginkgolide B Induces Apoptosis via Activation of JNK and p21-Activated Protein Kinase 2 in Mouse Embryonic Stem Cells. Ann. N.Y. Acad. Sci. 2009, 1171, 501-508.
    • (2009) Ann. N.Y. Acad. Sci. , vol.1171 , pp. 501-508
    • Hsuuw, Y.D.1    Kuo, T.F.2    Lee, K.H.3    Liu, Y.C.4    Huang, Y.T.5    Lai, C.Y.6    Chan, W.H.7
  • 12
    • 0028285576 scopus 로고
    • Ginkgo biloba extract (EGb 761) improves postischemic function in isolated preconditioned working rat hearts
    • Tosaki, A.; Engelman, D.T.; Pali, T.; Engelman, R.M.; Droy-Lefaix, M.T. Ginkgo biloba extract (EGb 761) improves postischemic function in isolated preconditioned working rat hearts. Coronary Artery Dis. 1994, 5, 443-450. (Pubitemid 24222649)
    • (1994) Coronary Artery Disease , vol.5 , Issue.5 , pp. 443-450
    • Tosaki, A.1    Engelman, D.T.2    Pali, T.3    Engelman, R.M.4    Droy-Lefaix, M.-T.5
  • 13
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • DOI 10.1126/science.1072682
    • Johnson, G.L.; Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298, 1911-1912. (Pubitemid 35425238)
    • (2002) Science , vol.298 , Issue.5600 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 14
    • 0031656856 scopus 로고    scopus 로고
    • Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro
    • DOI 10.1038/sj.bjp.0702049
    • Tsang, F.; Koh, A.H.; Ting, W.L.; Wong, P.T.; Wong, W.S. Effects of mitogen-activated protein kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. Br. J. Pharmacol. 1998, 25, 61-68. (Pubitemid 28418757)
    • (1998) British Journal of Pharmacology , vol.125 , Issue.1 , pp. 61-68
    • Tsang, F.1    Koh, A.H.M.2    Ting, W.L.3    Wong, P.T.H.4    Wong, W.S.F.5
  • 15
    • 0029856384 scopus 로고    scopus 로고
    • Effects of Ginkgo biloba extract and preconditioning on the diabetic rat myocardium
    • DOI 10.1007/s001250050567
    • Tosaki, A.; Pali, T.; Droy-Lefaix, M.T. Effects of Ginkgo biloba extract and preconditioning on the diabetic rat myocardium. Diabetologia 1996, 39, 1255-1262. (Pubitemid 26356051)
    • (1996) Diabetologia , vol.39 , Issue.11 , pp. 1255-1262
    • Tosaki, A.1    Pali, T.2    Droy-Lefaix, M.-T.3
  • 16
    • 78650631519 scopus 로고    scopus 로고
    • Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: A comparison with ibuprofen
    • Haines, D.D.; Varga, B.; Bak, I.; Juhasz, B.; Mahmoud, F.F.; Kalantari, H.; Gesztelyi, R.; Lekli, I.; Czompa, A.; Tosaki, A. Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen. Phytother. Res. 2011, 25, 128-136.
    • (2011) Phytother. Res. , vol.25 , pp. 128-136
    • Haines, D.D.1    Varga, B.2    Bak, I.3    Juhasz, B.4    Mahmoud, F.F.5    Kalantari, H.6    Gesztelyi, R.7    Lekli, I.8    Czompa, A.9    Tosaki, A.10
  • 17
    • 0027447670 scopus 로고
    • Effects of SOD, catalase, and a novel antiarrhythmic drug, EGB 761, on reperfusion-induced arrhythmias in isolated rat hearts
    • DOI 10.1016/0891-5849(93)90085-9
    • Tosaki, A.; Droy-Lefaix, M.T.; Pali, T.; Das, D.K. Effects of SOD, catalase, and a novel antiarrhythmic drug, EGB 761, on reperfusion-induced arrhythmias in isolated rat hearts. Free Radic. Biol. Med. 1993, 14, 361-370. (Pubitemid 23087399)
    • (1993) Free Radical Biology and Medicine , vol.14 , Issue.4 , pp. 361-370
    • Tosaki, A.1    Droy-Lefaix, M.-T.2    Pali, T.3    Das, D.K.4
  • 18
    • 0026643596 scopus 로고
    • Interleukin-5, eosinophils, and disease
    • Sanderson, C.J. Interleukin-5, eosinophils, and disease. Blood 1992, 79, 3101-3109.
    • (1992) Blood , vol.79 , pp. 3101-3109
    • Sanderson, C.J.1
  • 19
    • 0035496905 scopus 로고    scopus 로고
    • Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils
    • Dewson, G.; Cohen, G.M.; Wardlaw, A.J. Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils. Blood 2001, 98, 2239-2247.
    • (2001) Blood , vol.98 , pp. 2239-2247
    • Dewson, G.1    Cohen, G.M.2    Wardlaw, A.J.3
  • 20
    • 0025245434 scopus 로고
    • Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse
    • Sher, A.; Coffman, R.L.; Hieny, S.; Cheever, A.W. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J. Immunol. 1990, 145, 3911-3916.
    • (1990) J. Immunol. , vol.145 , pp. 3911-3916
    • Sher, A.1    Coffman, R.L.2    Hieny, S.3    Cheever, A.W.4
  • 23
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
    • DOI 10.1016/S0140-6736(02)11679-5
    • Green, R.H.; Brightling, C.E.; McKenna, S.; Hargadon, B.; Parker, D.; Bradding, P.; Wardlaw, A.J.; Pavord, I.D. Asthma exacerbations and sputum eosinophil counts: A randomized controlled trial. Lancet 2002, 360, 1715-1721. (Pubitemid 35447900)
    • (2002) Lancet , vol.360 , Issue.9347 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3    Hargadon, B.4    Parker, D.5    Bradding, P.6    Wardlaw, A.J.7    Pavord, I.D.8
  • 25
    • 0037385864 scopus 로고    scopus 로고
    • Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13
    • DOI 10.1165/rcmb.2002-0032OC
    • Vargaftig, B.B.; Singer, M. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am. J. Respir. Cell Mol. Biol. 2003, 28, 410-419. (Pubitemid 36399362)
    • (2003) American Journal of Respiratory Cell and Molecular Biology , vol.28 , Issue.4 , pp. 410-419
    • Vargaftig, B.B.1    Singer, M.2
  • 26
    • 0034049677 scopus 로고    scopus 로고
    • Mechanisms of eosinophil-associated inflammation
    • Gleich, G.J. Mechanisms of eosinophil-associated inflammation. J. Allergy Clin. Immunol. 2000, 105, 651-663. (Pubitemid 30226437)
    • (2000) Journal of Allergy and Clinical Immunology , vol.105 , Issue.4 , pp. 651-663
    • Gleich, G.J.1
  • 28
    • 14844300188 scopus 로고    scopus 로고
    • The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation
    • DOI 10.1016/j.jaci.2004.11.053
    • Holgate, S.; Casale, T.; Wenzel, S.; Bousquet, J.; Deniz, Y.; Reisner, C. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. J. Allergy Clin. Immunol. 2005, 115, 459-465. (Pubitemid 40341694)
    • (2005) Journal of Allergy and Clinical Immunology , vol.115 , Issue.3 , pp. 459-465
    • Holgate, S.1    Casale, T.2    Wenzel, S.3    Bousquet, J.4    Deniz, Y.5    Reisner, C.6
  • 29
    • 0036247432 scopus 로고    scopus 로고
    • T-cell activation through the antigen receptor. Part 1: Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse
    • DOI 10.1067/mai.2002.124259
    • Nel, A.E. T-cell activation through the antigen receptor. Part 1: Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J. Allergy Clin. Immunol. 2002, 109, 758-770. (Pubitemid 34499506)
    • (2002) Journal of Allergy and Clinical Immunology , vol.109 , Issue.5 , pp. 758-770
    • Nel, A.E.1
  • 30
    • 0037189571 scopus 로고    scopus 로고
    • Convergence of signaling pathways on the activation of ERK in B cells
    • DOI 10.1074/jbc.M202485200
    • Jacob, A.; Cooney, D.; Pradhan, M.; Coggeshall, K.M. Convergence of signaling pathways on the activation of ERK in B cells. J. Biol. Chem. 2002, 277, 23420-23426. (Pubitemid 34952174)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.26 , pp. 23420-23426
    • Jacob, A.1    Cooney, D.2    Pradhan, M.3    Mark Coggeshall, K.4
  • 31
    • 0037204949 scopus 로고    scopus 로고
    • B cell antigen receptor signaling: Roles in cell development and disease
    • DOI 10.1126/science.1071546
    • Gauld, S.B.; Dal Porto, J.M.; Cambier, J.C. B cell antigen receptor signaling: Roles in cell development and disease. Science 2002, 296, 1641-1642. (Pubitemid 34579149)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1641-1642
    • Gauld, S.B.1    Dal Porto, J.M.2    Cambier, J.C.3
  • 32
    • 0033753014 scopus 로고    scopus 로고
    • Signal transduction by the high-affinity immunoglobulin E receptor FcεRI: Coupling form to function
    • Nadler, M.J.; Matthews, S.A.; Turner, H.; Kinet, J.P. Signal transduction by the high-affinity immunoglobulin E receptor FcεRI: coupling form to function. Adv. Immunol. 2000, 76, 325-355. (Pubitemid 33717331)
    • (2001) Advances in Immunology , vol.76 , pp. 325-355
    • Nadler, M.J.S.1    Matthews, S.A.2    Turner, H.3    Kinet, J.-P.4
  • 33
    • 0141445981 scopus 로고    scopus 로고
    • Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: Implications in asthma
    • DOI 10.1096/fj.02-1148com
    • Kumar, A.; Lnu, S.; Malya, R.; Barron, D.; Moore, J.; Corry, D.B.; Boriek, A.M. Mechanical stretch activates nuclear factor-κB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma. FASEB J. 2003, 17, 1800-1811. (Pubitemid 37214774)
    • (2003) FASEB Journal , vol.17 , Issue.13 , pp. 1800-1811
    • Kumar, A.1    Lnu, S.2    Malya, R.3    Barron, D.4    Moore, J.5    Corry, D.B.6    Boriek, A.M.7
  • 34
    • 2442712697 scopus 로고    scopus 로고
    • Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model
    • Duan, W.; Chan, J.H.; Wong, C.H.; Leung, B.P.; Wong, W.S. Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J. Immunol. 2004, 172, 7053-7059. (Pubitemid 38669147)
    • (2004) Journal of Immunology , vol.172 , Issue.11 , pp. 7053-7059
    • Duan, W.1    Chan, J.H.P.2    Wong, C.H.3    Leung, B.P.4    Wong, W.S.F.5
  • 36
    • 0026739991 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin, H.; Staehelin, T.; Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Biotechnology 1992, 24, 145-149.
    • (1992) Biotechnology , vol.24 , pp. 145-149
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3


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