Alpha-synuclein deficiency and efferent nerve degeneration in the mouse cochlea: A possible cause of early-onset presbycusis

Neuroscience Research

Volumn 71, Issue 3, 2011, Pages 303-310

  Park, S N ^a   Back, S A ^a   Choung, Y H ^b   Kim, H L ^a   Akil, O ^c   Lustig, L R ^c   Park, K H ^a   Yeo, S W ^a  

^a The Catholic University of Korea   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Efferent nerve; Hearing loss; Presbycusis; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; SYNAPTOPHYSIN;

ALPHA SYNUCLEIN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COCHLEA; CONTROLLED STUDY; EFFERENT NERVE; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING LOSS; MALE; MOUSE; NERVE DEGENERATION; NERVE ENDING; NONHUMAN; PRESBYACUSIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; WESTERN BLOTTING;

AGE OF ONSET; ALPHA-SYNUCLEIN; ANIMALS; COCHLEA; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EFFERENT PATHWAYS; HAIR CELLS, AUDITORY, OUTER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; NERVE DEGENERATION; PRESBYCUSIS;

EID: 80053202378     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2011.07.1835     Document Type: Article

References (35)

1. Akil O., Weber C., Park S.N., Ninkina N., Buchman V., Lustig L.R. Localization of synucleins in the mammalian cochlea. J. Assoc. Res. Otolaryngol. 2008, 9:452-463.
2. Biere A., Wood S.J., Wypych J., Steavenson S., Jiang Y., Anafi D., Jacobsen F.W., Jarosinski M.A., Wu G.M., Louis J.C., Margin F., Narch L.O., Citron M., Parkinson's Disease-associated α-synuclein is more fibriollogenic than β- and (-synuclein and cannot cross-seed its homologs. J. Biol. Chem. 2000, 275:34574-34579.
3. Eybalin M. Neurotransmitters and neuromodulators of the mammalian cochlea. Physiol. Rev. 1993, 73:309-373.
4. Galambos R. Suppression of auditory nerve fibers by stimulation of efferent fibers to the cochlea. J. Neurophysiol. 1956, 19:424-437.
5. Guinan J.J. Olivocochlear efferents: anatomy, physiology, function and the measurement of efferent effects in humans. Ear Hear. 2006, 27:589-607.
6. Hultcrantz M., Li H.S. Inner ear morphology in CBA/Ca and C57BL/6J mice in relationship to noise, age and phenotype. Eur. Arch. Otorhinolaryngol. 1993, 250:257-264.
7. Jacobson M., Romney K.S., Zhu X., Frisina R.D. Contralateral suppression of distortion product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listeners. Laryngoscope 2003, 113:1707-1713.
8. Johnson K.R., Erway L.C., Cook S.A., Willot J.F., Zheng Q.Y. A major gene affecting age-related hearing loss in C57BL/6J mice. Hear. Res. 1997, 114:83-92.
9. Kim S.H., Frisina R.D. Effects of age on contralateral suppression of distortion product otoacoustic emissions in human listeners with normal hearing. Audiol. Neurotol. 2002, 7:348-357.
10. Klinke R., Galley N. Efferent innervation of vestibular and auditory receptors. Physiol. Rev. 1974, 54:316-357.
11. Lavedan C. The synuclein family. Genet. Res. 1998, 8:871-880.
12. Liberman M.C., Brown M.C. Physiology and anatomy of single olivocochlear neurons in the cat. Hear. Res. 1986, 24:17-36.
13. Liberman M.C. Response properties of cochlear efferent neurons: monaural vs. binaural stimulation and the effects of noise. J. Neurophysiol. 1988, 60:1779-1798.
14. Luebke A.E., Foster P.K. Variation in inter-animal susceptibility to noise damage is associated with alpha 9 acetylcholine receptor subunit expression level. J. Neurosci. 2002, 22:4241-4247.
15. Maison S.F., Liberman M.C. Predicting vulnerability to acoustic injury with a noninvasive assay of olivocochlear reflex strength. J. Neurosci. 2000, 20:4701-4707.
16. Maison S.F., Luebke A.E., Liberman M.C., Zuo J. Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells. J. Neurosci. 2002, 22:10838-10846.
17. Maison S.F., Adams J.C., Liberman M.C. Olivocochlear innervations in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization. J. Comp. Neurol. 2003, 455:406-416.
18. Maroteaux C.J., Scheller R.H. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 1988, 8:2804-2815.
19. Murphy D.D., Trojanowski J.Q., Lee V.M. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 2000, 20:3214-3220.
20. Ohlemiller K.K., Wright J.S., Heidbreder A.F. Vulnerability to noise-induced hearing loss in 'middle-aged' and young adult mice: a dose-response approach in CBA, C57BL, and BALB inbred strains. Hear. Res. 2000, 149:239-247.
21. Ohlemiller K.K., Gagnon P.M. Genetic dependence of cochlear cells and structures injured by noise. Hear. Res. 2007, 224:34-50.
22. Ohlemiller K.K., Dahl A.R., Gagnon P.M. Divergent aging characteristics in CBA/J and CBA/CaJ mouse cochleae. J. Assoc. Res. Otolaryngol. 2010, 11:605-623.
23. Ohlemiller K.K., Rosen A.D., Rellinger E.A., Montgomery S.C., Gagnon P.M. Different cellular and genetic basis of noise-related endocochlear potential reduction in CBA/J and BALB/cJ mice. J. Assoc. Res. Otolaryngol. 2011, 12:45-58.
24. Park O., Akil C., Weber L.R. Lustig early onset hearing loss and efferent auditory deficits in mice lacking α-synuclein. Abstract book of the thirty-second annual midwinter research meeting 2009, 13.
25. Park S.N., Back S.A., Park K.H., Kim D.K., Park S.Y., Oh J.H., Park Y.S., Yeo S.W. Comparison of cochlear morphology and apoptosis in mouse models of presbycusis. Clin. Exp. Otorhinolaryngol. 2010, 3:126-135.
26. Schuknecht H.F., Gacek M.R. Cochlear pathology in presbycusis. Ann. Otol. Rhinol. Laryngol. 1993, 102:1-16.
27. Siemens J., Lillo C., Dumont R.A., Reynolds A., Williams D.S., Gillespie P.G., Muller U. Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature 2004, 428:950-955.
28. Simmons D.D. Development of the inner ear efferent system across vertebrate species. J. Neurobiol. 2002, 53:228-250.
29. Surguchov S.I., Solessio E., Baehr W. Synoretin-a new protein belonging to the synuclein family. Mol. Cell. Neurosci. 1999, 13:95-103.
30. Tofaris G.K. Physiological and pathological properties of alpha-synuclein. Cell. Mol. Life Sci. 2007, 64:2194-2201.
31. Ueda K., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A., Kondo J., Ihara Y. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. 1993, 90:11282-11286.
32. Ueda K., Mori H. Tissue-dependent alternative splicing of messenger (-RNA for MACP, the precursor of non-α-b component of Alzheimer's disease amyloid. Biochem. Biophys. Res. Commun. 1994, 205:1366-1372.
33. Viberg A. The guide to plotting a cochleogram. Hear. Res. 2004, 197:1-10.
34. Wang Y., Hirose K., Liberman M.C. Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J. Assoc. Res. Otolaryngol. 2002, 3:248-268.
35. Wiederhold M.L., Kiang N.Y. Effects of electric stimulation of the crossed olivocochlear bundle on single auditory-nerve fibers in the cat. J. Acoust. Soc. Am. 1970, 48:950-965.