Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro

Biopharmaceutics and Drug Disposition

Volumn 32, Issue 7, 2011, Pages 408-425

  Jinno, Fumihiro ^a   Yoneyama, Tomoki ^a   Morohashi, Akio ^a   Kondo, Takahiro ^a   Asahi, Satoru ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

allylic rearrangement; covalent binding; glutathione; reactivity; serum albumin

Indexed keywords

CYCLOHEXANE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMAN SERUM ALBUMIN; PHOSPHATE BUFFERED SALINE; RADIOACTIVE MATERIAL; RESATORVID; SERUM ALBUMIN; UNCLASSIFIED DRUG; URANIUM; URANIUM 14;

ADDUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEOPHILICITY; PH MEASUREMENT; RAT; SUBSTITUTION REACTION;

ANIMALS; GLUTATHIONE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MOLECULAR STRUCTURE; RATS; SERUM ALBUMIN; SULFONAMIDES; TOLL-LIKE RECEPTOR 4;

EID: 80053188995     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.769     Document Type: Article

References (10)

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