Investigation of the unique metabolic fate of ethyl (6R)-6-[N-(2-chloro-4- fluorophenyl)sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242) in rats and dogs using two types of 14C-labeled compounds having different labeled positions

Arzneimittel-Forschung/Drug Research

Volumn 61, Issue 8, 2011, Pages 458-471

  Jinno, Fumihiro ^a   Kakehi, Masaaki ^a   Takeuchi, Toshiyuki ^a   Tagawa, Yoshihiko ^a   Kondo, Takahiro ^a   Asahi, Satoru ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Anti sepsis drug; Covalent binding; Metabolism; Pharmacokinetics; Species difference; TAK 242

Indexed keywords

2 CHLORO 4 FLUOROACETANILIDE; 2 CHLORO 4 FLUOROANILINE; 4 AMINO 3 CHLOROPHENYL HYDROGEN SULFATE; CARBON 14; CYCLOHEXENE DERIVATIVE; DRUG METABOLITE; GAMMA LEVO GLUTAMYL S[2 (ETHOXYCARBONYL) 2 CYCLOHEXENE 1 YL]LEVO CYSTEINYLGLYCINE; N ACETYL S[2 (ETHOXYCARBONYL) 2 CYCLOHEXENE 1 YL]LEVO CYSTEINYLGLYCINE; PHENYL GROUP; RESATORVID; S[2 (ETHOXYCARBONYL) 2 CYCLOHEXENE 1 YL]LEVO CYSTEINYLGLYCINE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COVALENT BOND; DOG; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; HYDROXYLATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 80052364473     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296228     Document Type: Article

References (12)

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