Differential effects of exogenous androgen and an androgen receptor antagonist in the peri- and postpubertal murine mammary gland

Endocrinology

Volumn 152, Issue 10, 2011, Pages 3728-3737

  Peters, A A ^a,c   Ingman, W V ^b   Tilley, Wayne D ^a   Butler, L M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FLUTAMIDE; PLACEBO;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CELL PROLIFERATION; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; IN VIVO STUDY; MAMMARY GLAND; MOUSE; NONHUMAN; PREPUBERTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANDROGEN ANTAGONISTS; ANIMALS; APOPTOSIS; CELL PROLIFERATION; DIHYDROTESTOSTERONE; EPITHELIAL CELLS; ESTRADIOL; FEMALE; FLUTAMIDE; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; SEXUAL MATURATION;

EID: 80053135925     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1133     Document Type: Article

References (64)

1. Dowsett M, Folkerd E, Doody D, Haynes B 2005 The biology of steroid hormones and endocrine treatment of breast cancer. Breast 14:452-457 (Pubitemid 41683566)
2. Yager JD, Davidson NE 2006 Estrogen carcinogenesis in breast cancer. N Engl J Med 354:270-282
3. Katzenellenbogen BS, Frasor J 2004 Therapeutic targeting in the estrogen receptor hormonal pathway. Semin Oncol 31:28-38 (Pubitemid 38543938)
4. Ingle JN, Twito DI, Schaid DJ, Cullinan SA, Krook JE, Mailliard JA, Tschetter LK, Long HJ, Gerstner JG, Windschitl HE, et al. 1991 Combination hormonal therapy with tamoxifen plus fluoxymesterone versus tamoxifen alone in postmenopausal women with metastatic breast cancer. An updated analysis. Cancer 67:886-891
5. Tormey DC, Lippman ME, Edwards BK, Cassidy JG 1983 Evaluation of tamoxifen doses with and without fluoxymesterone in advanced breast cancer. Ann Intern Med 98:139-144 (Pubitemid 13190908)
6. Birrell SN, Butler LM, Harris JM, Buchanan G, Tilley WD 2007 Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer. FASEB J 21:2285-2293
7. Moe RE, Anderson BO 2007 Androgens and androgen receptors: A clinically neglected sector in breast cancer biology. J Surg Oncol 95:437-439 (Pubitemid 46709384)
8. Andò S, De Amicis F, Rago V, Carpino A, Maggiolini M, Panno ML, Lanzino M 2002 Breast cancer: from estrogen to androgen receptor. Mol Cell Endocrinol 193:121-128 (Pubitemid 34823616)
9. Birrell SN, Bentel JM, Hickey TE, Ricciardelli C, Weger MA, Horsfall DJ, Tilley WD 1995 Androgens induce divergent proliferative responses in human breast cancer cell lines. J Steroid Biochem Mol Biol 52:459-467
10. Greeve MA, Allan RK, Harvey JM, Bentel JM 2004 Inhibition of MCF-7 breast cancer cell proliferation by 5α-dihydrotestosterone; a role for p21(Cip1/Waf1). J Mol Endocrinol 32:793-810 (Pubitemid 38877685)
11. Ortmann J, Prifti S, Bohlmann MK, Rehberger-Schneider S, Strowitzki T, Rabe T 2002 Testosterone and 5α-dihydrotestosterone inhibit in vitro growth of human breast cancer cell lines. Gynecol Endocrinol 16:113-120 (Pubitemid 34496877)
12. Poulin R, Baker D, Labrie F 1988 Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line. Breast Cancer Res Treat 12:213-225 (Pubitemid 19019103)
13. MacIndoe JH, Etre LA 1980 Androgens inhibit estrogen action in MCF-7 human breast cancer cells. Life Sci 27:1643-1648 (Pubitemid 11220220)
14. Macedo LF, Guo Z, Tilghman SL, Sabnis GJ, Qiu Y, Brodie A 2006 Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole. Cancer Res 66:7775-7782 (Pubitemid 44289238)
15. Poulin R, Simard J, Labrie C, Petitclerc L, Dumont M, Lagace L,Labrie F 1989 Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line. Endocrinology 125:392-399 (Pubitemid 19182686)
16. Dauvois S, Li SM, Martel C, Labrie F 1989 Inhibitory effect of androgens on DMBA-induced mammary carcinoma in the rat. Breast Cancer Res Treat 14:299-306 (Pubitemid 20053759)
17. Cops EJ, Bianco-Miotto T, Moore NL, Clarke CL, Birrell SN, Butler LM, Tilley WD 2008 Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors. J Steroid Biochem Mol Biol 110:236-243
18. Agoff SN, Swanson PE, Linden H, Hawes SE, Lawton TJ 2003 Androgen receptor expression in estrogen receptor-negative breast cancer. Immunohistochemical, clinical, and prognostic associations. Am J Clin Pathol 120:725-731 (Pubitemid 37339680)
19. Schippinger W, Regitnig P, Dandachi N, Wernecke KD, Bauernhofer T, Samonigg H, Moinfar F 2006 Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer. Virchows Arch 449:24-30 (Pubitemid 43988362)
20. Birrell SN, Hall RE, Tilley WD 1998 Role of the androgen receptor in human breast cancer. J Mammary Gland Biol Neoplasia 3:95-103 (Pubitemid 128513223)
21. Langer M, Kubista E, Schemper M, Spona J 1990 Androgen receptors, serum androgen levels and survival of breast cancer patients. Arch Gynecol Obstet 247:203-209 (Pubitemid 20232513)
22. Bryan RM, Mercer RJ, Bennett RC, Rennie GC, Lie TH, Morgan FJ 1984 Androgen receptors in breast cancer. Cancer 54:2436-2440 (Pubitemid 15223385)
23. Kuenen-Boumeester V, Van der Kwast TH, Claassen CC, Look MP, Liem GS, Klijn JG, Henzen-Logmans SC 1996 The clinical significance of androgen receptors in breast cancer and their relation to histological and cell biological parameters. Eur J Cancer 32A:1560-1565 (Pubitemid 26279124)
24. Peters AA, Buchanan G, Ricciardelli C, Bianco-Miotto T, Centenera MM, Harris JM, Jindal S, Segara D, Jia L, Moore NL, Henshall SM, Birrell SN, Coetzee GA, Sutherland RL, Butler LM, Tilley WD 2009 Androgen receptor inhibits estrogen receptor-α activity and is prognostic in breast cancer. Cancer Res 69:6131-6140
25. Gonzalez-Angulo AM, Stemke-Hale K, Palla SL, Carey M, Agarwal R, Meric-Berstam F, Traina TA, Hudis C, Hortobagyi GN, Gerald WL, Mills GB, Hennessy BT 2009 Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer. Clin Cancer Res 15:2472-2478
26. Agrawal AK, Jeleñ M, Grzebieniak Z, Zukrowski P, Rudnicki J, Nienartowicz E 2008 Androgen receptors as a prognostic and predictive factor in breast cancer. Folia Histochem Cytobiol 46:269-276
27. Søiland H, Kørner H, Skaland I, Janssen EA, Gudlaugsson E, Varhaug JE, Baak JP, Søreide JA 2008 Prognostic relevance of androgen receptor detection in operable breast cancer. J Surg Oncol 98:551-558
28. Ogawa Y, Hai E, Matsumoto K, Ikeda K, Tokunaga S, Nagahara H, Sakurai K, Inoue T, Nishiguchi Y 2008 Androgen receptor expression in breast cancer: relationship with clinicopathological factors and biomarkers. Int J Clin Oncol 13:431-435
29. Rakha EA, El-Sayed ME, Green AR, Lee AH, Robertson JF, Ellis IO 2007 Prognostic markers in triple-negative breast cancer. Cancer 109:25-32 (Pubitemid 46120191)
30. Labrie F 2006 Future perspectives of selective estrogen receptor modulators used alone and in combination with DHEA. Endocr Relat Cancer 13:335-355 (Pubitemid 43886662)
31. Dimitrakakis C, Zhou J, Wang J, Belanger A, LaBrie F, Cheng C, Powell D, Bondy C 2003 A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause 10:292-298 (Pubitemid 36870501)
32. Yeh S, Hu YC, Wang PH, Xie C, Xu Q, Tsai MY, Dong Z, Wang RS, Lee TH, Chang C 2003 Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med 198:1899-1908 (Pubitemid 38032122)
33. Shiina H, Matsumoto T, Sato T, Igarashi K, Miyamoto J, TakemasaS, Sakari M, Takada I, Nakamura T, Metzger D, Chambon P, Kanno J, Yoshikawa H, Kato S 2006 Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci USA 103:224-229 (Pubitemid 43076131)
34. Casey RW, Wilson JD 1984 Antiestrogenic action of dihydrotestosterone in mouse breast. Competition with estradiol for binding to the estrogen receptor. J Clin Invest 74:2272-2278 (Pubitemid 15197372)
35. Jayo MJ, Register TC, Hughes CL, Blas-Machado U, Sulistiawati E, Borgerink H, Johnson CS 2000 Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats. J Soc Gynecol Investig 7:257-265 (Pubitemid 30665624)
36. Skarda J 2002 Sensitivity and specificity of bioassay of estrogenicity on mammary gland and uterus of female mice. Physiol Res 51:407-412 (Pubitemid 35278051)
37. Zhou J, Ng S, Adesanya-Famuiya O, Anderson K, Bondy CA 2000 Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB J 14:1725-1730
38. Zhang J, Sun Y, Liu Y, Sun Y, Liao DJ 2004 Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland. Oncol Rep 12:709-716
39. Sourla A, Martel C, Labrie C, Labrie F 1998 Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland. Endocrinology 139:753-764 (Pubitemid 28513228)
40. McNamara KM, Harwood DT, Simanainen U, Walters KA, Jimenez M, Handelsman DJ 2010 Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry. J Steroid Biochem Mol Biol 121:611-618
41. Weng Y, Xie F, Xu L, Zagorevski D, Spink DC, Ding X 2010 Analysis of testosterone and dihydrotestosterone in mouse tissues by liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal Biochem 402:121-128
42. Ricciardelli C, Choong CS, Buchanan G, Vivekanandan S, Neufing P, Stahl J, Marshall VR, Horsfall DJ, Tilley WD 2005 Androgen receptor levels in prostate cancer epithelial and peritumoral stromal cells identify non-organ confined disease. Prostate 63:19-28 (Pubitemid 40365387)
43. Lanzino M, De Amicis F, McPhaul MJ, Marsico S, Panno ML, Andò S 2005 Endogenous coactivator ARA70 interacts with ERa and modulates the functional ERα/AR interplay in MCF-7 cells. J Biol Chem 280:20421-20430
44. Rochefort H, Garcia M 1976 Androgen on the estrogen receptor. I. Binding and in vivo nuclear translocation. Steroids 28:549-560 (Pubitemid 8002205)
45. Ekena K, Katzenellenbogen JA, Katzenellenbogen BS 1998 Determinants of ligand specificity of estrogen receptor-α: estrogen versus androgen discrimination. J Biol Chem 273:693-699 (Pubitemid 28049154)
46. Haslam SZ, Nummy KA 1992 The ontogeny and cellular distribution of estrogen receptors in normal mouse mammary gland. J Steroid Biochem Mol Biol 42:589-595
47. Shyamala G, Chou YC, Louie SG, Guzman RC, Smith GH, Nandi S 2002 Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging. J Steroid Biochem Mol Biol 80:137-148 (Pubitemid 34233736)
48. Stanczyk FZ, Bretsky P 2003 Biosynthesis, transport and metabolism of steroid hormones. In: Henderson BE, Ponder B, Ross RK, eds. Hormones, genes, and cancer. New York: Oxford University Press; 12-34
49. Weihua Z, Makela S, Andersson LC, Salmi S, Saji S, Webster JI, Jensen EV, Nilsson S, Warner M, Gustafsson JA 2001 A role for estrogen receptor β in the regulation of growth of the ventral prostate. Proc Natl Acad Sci USA 98:6330-6335 (Pubitemid 32492315)
50. Oliveira AG, Coelho PH, Guedes FD, Mahecha GA, Hess RA, Oliveira CA 2007 5α-Androstane-3β,17β-diol (3β-diol), an estrogenic metabolite of 5α-dihydrotestosterone, is a potent modulator of estrogen receptor ERα expression in the ventral prostrate of adult rats. Steroids 72:914-922 (Pubitemid 47600274)
51. Thériault C, Labrie F 1991 Multiple steroid metabolic pathways in ZR-75-1 human breast cancer cells. J Steroid Biochem Mol Biol 38:155-164
52. Roy R, Dauvois S, Labrie F, Belanger A 1992 Estrogen-stimulated glucuronidation of dihydrotestosterone in MCF-7 human breast cancer cells. J Steroid Biochem Mol Biol 41:579-582
53. Xie B, Tsao SW, Wong YC 1999 Sex hormone-induced mammary carcinogenesis in female noble rats: the role of androgens. Carcinogenesis 20:1597-1606 (Pubitemid 29385451)
54. Leung G, Tsao SW, Wong YC 2002 The effect of flutamide and tamoxifen on sex hormone-induced mammary carcinogenesis and pituitary adenoma. Breast Cancer Res Treat 72:153-162 (Pubitemid 34407210)
55. Russo IH, Russo J 1996 Mammary gland neoplasia in long-term rodent studies. Environ Health Perspect 104:938-967 (Pubitemid 26372400)
56. Anderson E, Clarke RB 2004 Steroid receptors and cell cycle in normal mammary epithelium. J Mammary Gland Biol Neoplasia 9:3-13 (Pubitemid 39137493)
57. Russo J, Ao X, Grill C, Russo IH 1999 Pattern of distribution of cells positive for estrogen receptor α and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat 53:217-227 (Pubitemid 29209891)
58. Zeps N, Bentel JM, Papadimitriou JM, D'Antuono MF, Dawkins HJ 1998 Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth. Differentiation 62:221-226
59. Clarke RB, Howell A, Potten CS, Anderson E 1997 Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res 57:4987-4991 (Pubitemid 27498105)
60. Shoker BS, Jarvis C, Clarke RB, Anderson E, Hewlett J, Davies MP, Sibson DR, Sloane JP 1999 Estrogen receptor-positive proliferating cells in the normal and precancerous breast. Am J Pathol 155:1811-1815
61. Mueller SO, Clark JA, Myers PH, Korach KS 2002 Mammary gland development in adult mice requires epithelial and stromal estrogen receptor α. Endocrinology 143:2357-2365 (Pubitemid 34521582)
62. Cheng G, Weihua Z, Warner M, Gustafsson JA 2004 Estrogen receptors ERα and ERβ in proliferation in the rodent mammary gland. Proc Natl Acad Sci USA 101:3739-3746 (Pubitemid 38386631)
63. Bocchinfuso WP, Korach KS 1997 Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J Mammary Gland Biol Neoplasia 2:323-334
64. Pike MC, Spicer DV 1993 The chemoprevention of breast cancer by reducing sex steroid exposure: perspectives from epidemiology. J Cell Biochem Suppl 17G:26-36