The diabetic heart: Sweet, fatty and stressed

Expert Review of Cardiovascular Therapy

Volumn 9, Issue 9, 2011, Pages 1093-1096

  Stratmann, Bernd ^a   Tschoepe, Diethelm ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

diabetic cardiomyopathy; glucotoxicity; inflammation; lipotoxicity; oxidative stress

Indexed keywords

DIABETES MELLITUS; DIABETIC CARDIOMYOPATHY; DISEASE ASSOCIATION; HEART FAILURE; HUMAN; HYPERGLYCEMIA; REVIEW; RISK FACTOR;

ANIMALS; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHIES; HEART FAILURE; HUMANS; HYPERGLYCEMIA;

EID: 80053124679     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.11.109     Document Type: Review

References (18)

1. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with Type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N. Engl. J. Med. 339, 229-234 (1998). (Pubitemid 28350165)
2. Hayat SA, Patel B, Khattar RS, Malik RA. Diabetic cardiomyopathy: mechanisms, diagnosis and treatment. Clin. Sci. 107, 539-557 (2004). (Pubitemid 39627201)
3. Aneja A, Tang WH, Bansilal S, Garcia MJ, Farkouh ME. Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am. J. Med. 121, 748-757 (2004).
4. Lieb W, Xanthakis V, Sullivan LM et al. Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study. Circulation 119, 3085-3092 (2009).
5. Borisov AB, Ushakov AV, Zagorulko AK et al. Intracardiac lipid accumulation, lipoatrophy of muscle cells and expansion of myocardial infarction in Type 2 diabetic patients. Micron 39, 944-951 (2008).
6. van Heerebeek L, Hamdani N, Handoko ML et al. Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension. Circulation 117, 43-51 (2008). (Pubitemid 350291180)
7. Gertz EW, Wisneski JA, Stanley WC, Neese RA. Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments. J. Clin. Invest. 82, 2017-25 (1988). (Pubitemid 19054950)
8. von Lewinski D, Gasser R, Rainer PP et al. Functional effects of glucose transporters in human ventricular myocardium. Eur. J. Heart Fail. 12, 106-113 (2010).
9. Murray AJ, Anderson RE, Watson GC, Radda GK, Clarke K. Uncoupling proteins in human heart. Lancet 364, 1786-1788 (2004). (Pubitemid 39488064)
10. Peterson LR, Herrero P, Schechtman KB et al. Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109, 2191-2196 (2004). (Pubitemid 38625396)
11. Monnier L, Mas E, Ginet C et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with Type 2 diabetes. JAMA 295, 1681-1687 (2006).
12. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414, 813-820 (2001). (Pubitemid 34000785)
13. Hotamisligil GS. Inflammation and metabolic disorders. Nature 444, 860-867 (2006). (Pubitemid 46024993)
14. Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440, 944-948 (2006).
15. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113, 1888-1904 (2006). (Pubitemid 43739401)
16. Rask-Madsen C, Dominguez H, Ihlemann N, Hermann T, Kober L, Torp-Pedersen C. Tumor necrosis factor-a inhibits insulins stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 108, 1815-1821 (2003). (Pubitemid 37296090)
17. Kim F, Gallis B, Corson MA. TNF-a inhibits flow and insulin signaling leading to NO production in aortic endothelial cells. Am. J. Physiol. Cell Physiol. 280, C1057-C1065 (2001).
18. Picchi A, Gao X, Belmadani S et al. Tumor necrosis factor-a induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ. Res. 99, 69-77 (2006). (Pubitemid 44297057)