Antinociceptive action of GLYX-13: An N-methyl-D-aspartate receptor glycine site partial agonist

NeuroReport

Volumn 19, Issue 10, 2008, Pages 1061-1063

  Wood, Paul L ^b   Mahmood, Siddique A ^b   Moskal, Joseph R ^a,c  

^a Northwestern University   (United States)

^b Naurex Inc   (United States)

^c NW University Research Park   (United States)

Author keywords

Chronic nerve constrictionmodel; Formalinmodel; Gabapentin; GLYX 13; Neuropathic pain; Partial glycine agonist

Indexed keywords

FORMALDEHYDE; GABAPENTIN; GLYCINE RECEPTOR AGONIST; GLYX 13; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; AMINE; ANALGESIC AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; GLYX 13 PEPTIDE; GLYX-13 PEPTIDE; OLIGOPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; ATAXIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; MALE; NERVE COMPRESSION; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; SPRAGUE DAWLEY RAT; TIME;

AMINES; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; GAMMA-AMINOBUTYRIC ACID; MALE; OLIGOPEPTIDES; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 67249089972     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32830435c9     Document Type: Article

References (14)

1. Childers WE Jr, Baudy RB. N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief. J Med Chem 2007; 50:2557-2562.
2. Priestley T, Marshall GR, Hill RG, Kemp JA. L-687,414, a low efficacy NMDA receptor glycine site partial agonist in vitro, does not prevent hippocampal LTP in vivo at plasma levels known to be neuroprotective. Br J Pharmacol 1998; 124:1767-1773.
3. Singh L, Field MJ, Ferris P, Hunter JC, Oles RJ, Williams RG, Woodruff GN. The antiepileptic agent gabapentin (Neurontin) possesses anxiolyticlike and antinociceptive actions that are reversed by D-serine. Psychopharmacology (Berl) 1996; 127:1-9.
4. Yoon MH, Yaksh TL. The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. Anesth Analg 1999; 89:434-439.
5. Hendrich J, Van Minh AT, Heblich F, Nueti-Rostro M, Watschinger K, Striessniq J, et al. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A 2008; 105:3628-3633.
6. Moskal JR, Kuo AG, Weiss C, Wood PL, O'Connor Hanson A, Kelso S, et al. GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology 2005; 49:1077-1087.
7. Abbott FV, Franklin KB, Westbrook RF. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain 1995; 60:91-102.
8. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988; 33:87-107.
9. Parsons CG, Danysz W, Quack G. Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspect 1998; 11:523-569.
10. Kristensen JD, Svensson B, Gordh T Jr. The NMDA-receptor antagonist CPP abolishes neurogenic 'wind-up pain' after intrathecal administration in humans. Pain 1992; 51:249-253.
11. Brandt MR, Cummons TA, Potestio L, Sukoff SJ, Rosenzweig-Lipson S. Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)-ethyl)phophonic acid] on chemically induced thermal hypersensitivity. J Phamacol Exp Ther 2005; 313:1379-1386.
12. Leung A, Wallace MS, Ridgeway B, Yaksh T. Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. Pain 2005; 91:177-187.
13. Nakazato E, Kato A, Watanabe S. Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101, 606 in a rat chronic constriction injury model. Phamacol 2005; 73:8-14.
14. Gilron I. Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future diretions. Curr Opin Anaesthesiol 2007; 20:456-472.