At least it won't hurt: The personal risks of antibiotic exposure

Current Opinion in Pharmacology

Volumn 11, Issue 5, 2011, Pages 446-452

  Stewardson, Andrew J ^a   Huttner, Benedikt ^a,b   Harbarth, Stephan ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; AZITHROMYCIN; CIPROFLOXACIN; EXTENDED SPECTRUM BETA LACTAMASE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

AMPICILLIN RESISTANT ESCHERICHIA COLI; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTEREMIA; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIUM CARRIER; CLOSTRIDIUM DIFFICILE INFECTION; COMMENSAL; DNA SEQUENCE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INTESTINE FLORA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOME; NONHUMAN; PRIORITY JOURNAL; REVIEW; STREPTOCOCCUS PNEUMONIAE; TAXONOMY; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; DRUG RESISTANCE, BACTERIAL; HUMANS; INTESTINES; METAGENOME;

EID: 80053108033     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2011.06.011     Document Type: Review

References (56)

1. B. Huttner, H. Goossens, T. Verheij, and S. Harbarth Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries Lancet Infect Dis 10 2010 17 31
2. K. Gupta, T.M. Hooton, K.G. Naber, B. Wullt, R. Colgan, L.G. Miller, G.J. Moran, L.E. Nicolle, R. Raz, and A.J. Schaeffer International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases Clin Infect Dis 52 2011 e103 e120
3. N. Vernaz, B. Huttner, D. Muscionico, J.L. Salomon, P. Bonnabry, J.M. Lopez-Lozano, A. Beyaert, J. Schrenzel, and S. Harbarth Modelling the impact of antibiotic use on antibiotic-resistant Escherichia coli using population-based data from a large hospital and its surrounding community J Antimicrob Chemother 66 2011 928 935
4. N. Shehab, P.R. Patel, A. Srinivasan, and D.S. Budnitz Emergency department visits for antibiotic-associated adverse events Clin Infect Dis 47 2008 735 743
5. E.K. Costello, C.L. Lauber, M. Hamady, N. Fierer, J.I. Gordon, and R. Knight Bacterial community variation in human body habitats across space and time Science 326 2009 1694 1697
6. M. Wlodarska, and B.B. Finlay Host immune response to antibiotic perturbation of the microbiota Mucosal Immunol 3 2010 100 103
7. J.M. Kinross, A.W. Darzi, and J.K. Nicholson Gut microbiome-host interactions in health and disease Genome Med 3 2011 14
8. J. Penders, C. Thijs, C. Vink, F.F. Stelma, B. Snijders, I. Kummeling, P.A. van den Brandt, and E.E. Stobberingh Factors influencing the composition of the intestinal microbiota in early infancy Pediatrics 118 2006 511 521 (Pubitemid 46085405)
9. S. Hussey, R. Wall, E. Gruffman, L. O'Sullivan, C.A. Ryan, B. Murphy, G. Fitzgerald, C. Stanton, and R.P. Ross Parenteral antibiotics reduce Bifidobacteria colonization and diversity in neonates Int J Microbiol 2011 10.1155/2011/130574
10. M. Fallani, D. Young, J. Scott, E. Norin, S. Amarri, R. Adam, M. Aguilera, S. Khanna, A. Gil, and C.A. Edwards Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics J Pediatr Gastroenterol Nutr 51 2010 77 84
11. L. Dethlefsen, S. Huse, M.L. Sogin, and D.A. Relman The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing PLoS Biol 6 2008 e280
12. L. Dethlefsen, and D.A. Relman Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation Proc Natl Acad Sci U S A 108 Suppl. 1 2011 4554 4561
13. H.E. Jakobsson, C. Jernberg, A.F. Andersson, M. Sjolund-Karlsson, J.K. Jansson, and L. Engstrand Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome PLoS One 5 2010 e9836
14. C. Ubeda, Y. Taur, R.R. Jenq, M.J. Equinda, T. Son, M. Samstein, A. Viale, N.D. Socci, M.R. van den Brink, and M. Kamboj Vancomycin-resistant enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans J Clin Invest 120 2010 4332 4341
15. A.R. Manges, A. Labbe, V.G. Loo, J.K. Atherton, M.A. Behr, L. Masson, P.A. Tellis, and R. Brousseau Comparative metagenomic study of alterations to the intestinal microbiota and risk of nosocomial Clostridium difficile-associated disease J Infect Dis 202 2010 1877 1884
16. C. Rousseau, F. Levenez, C. Fouqueray, J. Dore, A. Collignon, and P. Lepage Clostridium difficile colonization in early infancy is accompanied by changes in intestinal microbiota composition J Clin Microbiol 49 2011 858 865
17. M.J. Grehan, T.J. Borody, S.M. Leis, J. Campbell, H. Mitchell, and A. Wettstein Durable alteration of the colonic microbiota by the administration of donor fecal flora J Clin Gastroenterol 44 2010 551 561
18. A. Khoruts, J. Dicksved, J.K. Jansson, and M.J. Sadowsky Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea J Clin Gastroenterol 44 2010 354 360
19. C. Costelloe, C. Metcalfe, A. Lovering, D. Mant, and A.D. Hay Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis BMJ 340 2010 c2096
20. P.J. Rooney, M.C. O'Leary, A.C. Loughrey, M. McCalmont, B. Smyth, P. Donaghy, M. Badri, N. Woodford, E. Karisik, and D.M. Livermore Nursing homes as a reservoir of extended-spectrum beta-lactamase (ESBL)-producing ciprofloxacin-resistant Escherichia coli J Antimicrob Chemother 64 2009 635 641
21. A. March, R. Aschbacher, H. Dhanji, D.M. Livermore, A. Bottcher, F. Sleghel, S. Maggi, M. Noale, C. Larcher, and N. Woodford Colonization of residents and staff of a long-term-care facility and adjacent acute-care hospital geriatric unit by multiresistant bacteria Clin Microbiol Infect 16 2010 934 944
22. M. Arnan, C. Gudiol, L. Calatayud, J. Linares, M.A. Dominguez, M. Batlle, J.M. Ribera, J. Carratala, and F. Gudiol Risk factors for, and clinical relevance of, faecal extended-spectrum beta-lactamase producing Escherichia coli (ESBL-EC) carriage in neutropenic patients with haematological malignancies Eur J Clin Microbiol Infect Dis 30 2011 355 360
23. M. Ortega, F. Marco, A. Soriano, M. Almela, J.A. Martinez, A. Munoz, and J. Mensa Analysis of 4758 Escherichia coli bacteraemia episodes: predictive factors for isolation of an antibiotic-resistant strain and their impact on the outcome J Antimicrob Chemother 63 2009 568 574
24. O.K. Azap, H. Arslan, K. Serefhanoglu, S. Colakoglu, H. Erdogan, F. Timurkaynak, and S.S. Senger Risk factors for extended-spectrum beta-lactamase positivity in uropathogenic Escherichia coli isolated from community-acquired urinary tract infections Clin Microbiol Infect 16 2010 147 151
25. C. Gudiol, L. Calatayud, C. Garcia-Vidal, J. Lora-Tamayo, M. Cisnal, R. Duarte, M. Arnan, M. Marin, J. Carratala, and F. Gudiol Bacteraemia due to extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) in cancer patients: clinical features, risk factors, molecular epidemiology and outcome J Antimicrob Chemother 65 2010 333 341
26. D. Marchaim, T. Gottesman, O. Schwartz, M. Korem, Y. Maor, G. Rahav, R. Karplus, T. Lazarovitch, E. Braun, and H. Sprecher National multicenter study of predictors and outcomes of bacteremia upon hospital admission caused by Enterobacteriaceae producing extended-spectrum beta-lactamases Antimicrob Agents Chemother 54 2010 5099 5104
27. J. Rodriguez-Bano, E. Picon, P. Gijon, J.R. Hernandez, M. Ruiz, C. Pena, M. Almela, B. Almirante, F. Grill, and J. Colomina Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis Clin Infect Dis 50 2010 40 48
28. P.L. Woerther, C. Angebault, M. Lescat, E. Ruppe, D. Skurnik, A.E. Mniai, O. Clermont, H. Jacquier, A.D. Costa, and M. Renard Emergence and dissemination of extended-spectrum beta-lactamase-producing Escherichia coli in the community: lessons from the study of a remote and controlled population J Infect Dis 202 2010 515 523
29. U.O. Luvsansharav, I. Hirai, M. Niki, T. Sasaki, K. Makimoto, C. Komalamisra, W. Maipanich, T. Kusolsuk, S. Sa-Nguankiat, and S. Pubampen Analysis of risk factors for a high prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in asymptomatic individuals in rural Thailand J Med Microbiol 60 2011 619 624
30. A. Courpon-Claudinon, A. Lefort, X. Panhard, O. Clermont, Q. Dornic, B. Fantin, F. Mentre, M. Wolff, E. Denamur, and C. Branger Bacteraemia caused by third-generation cephalosporin-resistant Escherichia coli in France: prevalence, molecular epidemiology and clinical features Clin Microbiol Infect 17 2011 557 565
31. M.H. Samore, C. Tonnerre, E.L. Hannah, G.J. Stoddard, R.J. Borotkanics, B. Haddadin, and S. Harbarth Impact of outpatient antibiotic use on carriage of ampicillin-resistant Escherichia coli Antimicrob Agents Chemother 55 2011 1135 1141
32. A. Valverde, F. Grill, T.M. Coque, V. Pintado, F. Baquero, R. Canton, and J. Cobo High rate of intestinal colonization with extended-spectrum-beta- lactamase-producing organisms in household contacts of infected community patients J Clin Microbiol 46 2008 2796 2799
33. D. Tande, S. Boisrame-Gastrin, M.R. Munck, G. Hery-Arnaud, S. Gouriou, N. Jallot, P. Nordmann, and T. Naas Intrafamilial transmission of extended-spectrum-beta-lactamase-producing Escherichia coli and Salmonella enterica babelsberg among the families of internationally adopted children J Antimicrob Chemother 65 2010 859 865
34. V. de Lastours, F. Chau, F. Tubach, B. Pasquet, E. Ruppe, and B. Fantin Independent behavior of commensal flora for carriage of fluoroquinolone- resistant bacteria in patients at admission Antimicrob Agents Chemother 54 2010 5193 5200
35. J. Nicoletti, S.P. Kuster, T. Sulser, R. Zbinden, C. Ruef, B. Ledergerber, and R. Weber Risk factors for urinary tract infections due to ciprofloxacin-resistant Escherichia coli in a tertiary care urology department in Switzerland Swiss Med Wkly 140 2010 w13059
36. W.E. van der Starre, C. van Nieuwkoop, S. Paltansing, J.W. Van't Wout, G.H. Groeneveld, M.J. Becker, T. Koster, G.H. Wattel-Louis, N.M. Delfos, and H.C. Ablij Risk factors for fluoroquinolone-resistant Escherichia coli in adults with community-onset febrile urinary tract infection J Antimicrob Chemother 66 2011 650 656
37. T. Yasufuku, K. Shigemura, T. Shirakawa, Y. Nakano, K. Tanaka, S. Arakawa, S. Kinoshita, K. Nishimura, M. Kawabata, and M. Fujisawa Risk factors and mechanisms of fluoroquinolone resistance in 156 Escherichia coli strains clinically isolated from urinary tract infections Scand J Infect Dis 43 2011 83 88
38. E. Tacconelli, G. De Angelis, M.A. Cataldo, E. Pozzi, and R. Cauda Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis J Antimicrob Chemother 61 2008 26 38
39. M. Lipsitch, and M.H. Samore Antimicrobial use and antimicrobial resistance: a population perspective Emerg Infect Dis 8 2002 347 354 (Pubitemid 34415194)
40. W.T. Lo, C.C. Wang, W.J. Lin, S.R. Wang, C.S. Teng, C.F. Huang, and S.J. Chen Changes in the nasal colonization with methicillin-resistant Staphylococcus aureus in children: 2004-2009 PLoS One 5 2010 e15791
41. M.B. Miller, D.J. Weber, J.S. Goodrich, E.B. Popowitch, M.D. Poe, V. Nyugen, T.R. Shope, D.T. Foster, J.R. Miller, and J. Kotch Prevalence and risk factor analysis for methicillin-resistant Staphylococcus aureus nasal colonization in children attending child care centers J Clin Microbiol 49 2011 1041 1047
42. N. Safdar, and E.A. Bradley The risk of infection after nasal colonization with Staphylococcus aureus Am J Med 121 2008 310 315 (Pubitemid 351417832)
43. H. Honda, M.J. Krauss, C.M. Coopersmith, M.H. Kollef, A.M. Richmond, V.J. Fraser, and D.K. Warren Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: Does methicillin resistance matter? Infect Control Hosp Epidemiol 31 2010 584 591
44. R. Cohen, C. Levy, E. Bonnet, F. Thollot, M. Boucherat, B. Fritzell, V. Derkx, E. Bingen, and E. Varon Risk factors for serotype 19A carriage after introduction of 7-valent pneumococcal vaccination BMC Infect Dis 11 2011 95
45. A.H. Skalet, V. Cevallos, B. Ayele, T. Gebre, Z. Zhou, J.H. Jorgensen, M. Zerihun, D. Habte, Y. Assefa, and P.M. Emerson Antibiotic selection pressure and macrolide resistance in nasopharyngeal Streptococcus pneumoniae: a cluster-randomized clinical trial PLoS Med 7 2010 e1000377
46. J.W. Mouton, P.G. Ambrose, R. Canton, G.L. Drusano, S. Harbarth, A. Macgowan, U. Theuretzbacher, and J. Turnidge Conserving antibiotics for the future: new ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective Drug Resist Updat 14 2011 107 117
47. B. Fantin, X. Duval, L. Massias, L. Alavoine, F. Chau, S. Retout, A. Andremont, and F. Mentre Ciprofloxacin dosage and emergence of resistance in human commensal bacteria J Infect Dis 200 2009 390 398
48. R.C. Owens Jr., C.J. Donskey, R.P. Gaynes, V.G. Loo, and C.A. Muto Antimicrobial-associated risk factors for Clostridium difficile infection Clin Infect Dis 46 Suppl. 1 2008 S19 S31
49. T.J. Sandora, M. Fung, K. Flaherty, L. Helsing, P. Scanlon, G. Potter-Bynoe, C.A. Gidengil, and G.M. Lee Epidemiology and risk factors for Clostridium difficile infection in children Pediatr Infect Dis J 2011 10.1097/INF.0b013e31820fb29
50. M.A. Aldeyab, M.J. Devine, P. Flanagan, M. Mannion, A. Craig, M.G. Scott, S. Harbarth, N. Vernaz, E. Davies, and J.S. Brazier Multihospital outbreak of Clostridium difficile ribotype 027 infection: epidemiology and analysis of control measures Infect Control Hosp Epidemiol 32 2011 210 219
51. P.K. Kutty, C.W. Woods, A.C. Sena, S.R. Benoit, S. Naggie, J. Frederick, S. Evans, J. Engel, and L.C. McDonald Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA Emerg Infect Dis 16 2010 197 204
52. P.J. Lambert, M. Dyck, L.H. Thompson, and G.W. Hammond Population-based surveillance of Clostridium difficile infection in Manitoba, Canada, by using interim surveillance definitions Infect Control Hosp Epidemiol 30 2009 945 951
53. S. Borgmann, T. Jakobiak, H. Gruber, M. Reil, H. Schroder, M. Kist, and U. Sagel Association of ciprofloxacin prescriptions to outpatients to Clostridium difficile infections Euro Surveill 15 2010 pii: 19479
54. G. Fellmeth, S. Yarlagadda, and S. Iyer Epidemiology of community-onset Clostridium difficile infection in a community in the south of England J Infect Public Health 3 2010 118 123
55. M.P. Bauer, D.W. Notermans, B.H. van Benthem, J.S. Brazier, M.H. Wilcox, M. Rupnik, D.L. Monnet, J.T. van Dissel, and E.J. Kuijper Clostridium difficile infection in Europe: a hospital-based survey Lancet 377 2011 63 73
56. P. Rotjanapan, D. Dosa, and K.S. Thomas Potentially inappropriate treatment of urinary tract infections in two Rhode Island nursing homes Arch Intern Med 171 2011 438 443