Nutritional and micronutrient determinants of idiopathic dilated cardiomyopathy: Diagnostic and therapeutic implications

Expert Review of Cardiovascular Therapy

Volumn 9, Issue 9, 2011, Pages 1161-1170

  Marinescu, Victor ^a   McCullough, Peter A ^b  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b St John Providence Health System   (United States)

Author keywords

heart failure; idiopathic dilated cardiomyopathy; macrominerals; metabolic cardiology; micronutrients; multinutrient supplementation; vitamins

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARNITINE; COPPER; CREATINE; CYANOCOBALAMIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HOMOCYSTEINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRON; MAGNESIUM; OMEGA 3 FATTY ACID; RIBOSE; SELENIUM; SODIUM; TAURINE; TRACE ELEMENT; VITAMIN B COMPLEX; VITAMIN D; ZINC;

CALCIUM DEFICIENCY; CARNITINE DEFICIENCY; CELL DEATH; CLINICAL FEATURE; CONGESTIVE CARDIOMYOPATHY; ENERGY EXPENDITURE; ESSENTIAL FATTY ACID DEFICIENCY; FOLIC ACID DEFICIENCY; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HEART VENTRICLE REMODELING; HUMAN; MAGNESIUM DEFICIENCY; NONHUMAN; NUTRITIONAL DEFICIENCY; PATHOGENESIS; POTASSIUM DEFICIENCY; REVIEW; SELENIUM DEFICIENCY; SUPPLEMENTATION; THIAMINE DEFICIENCY; TISSUE REPAIR; VITAMIN DEFICIENCY; ZINC DEFICIENCY;

ANIMALS; CARDIOMYOPATHY, DILATED; DIETARY SUPPLEMENTS; ENERGY METABOLISM; HEART FAILURE; HUMANS; MALNUTRITION; MICRONUTRIENTS; PREVALENCE;

EID: 80053104349     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.11.95     Document Type: Review

References (76)

1. Hunt SA, Abraham WT, Chin MH et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 112, e154-e235 (2005).
2. Kannel WB, Plehn JF, Cupples LA. Cardiac failure and sudden death in the Framingham Study. Am. Heart J. 115, 869-875 (1988). (Pubitemid 18093155)
3. Lloyd-Jones D, Adams R, Carnethon M et al. Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119, e21-e181 (2009).
4. Ingwall JS. On the hypothesis that the failing heart is energy starved: lessons learned from the metabolism of ATP and creatine. Curr. Hypertens. Rep. 8, 457-464 (2006). (Pubitemid 44842771)
5. Pouleur H. Diastolic dysfunction and myocardial energetics. Eur. Heart J. 11(Suppl. C), 30-34 (1990). (Pubitemid 20179615)
6. Feldman AM, McNamara D. Myocarditis. N. Engl. J. Med. 343, 1388-1398 (2000).
7. Woodruff JF. Viral myocarditis. A review. Am. J. Pathol. 101, 425-484 (1980).
8. Goerss JB, Michels VV, Burnett J et al. Frequency of familial dilated cardiomyopathy. Eur. Heart J. 16(Suppl. O), 2-4 (1995). (Pubitemid 26082332)
9. Michels VV. Progress in defining the causes of idiopathic dilated cardiomyopathy. N. Engl. J. Med. 329, 960-961 (1993). (Pubitemid 23275281)
10. van Tellingen C. Quibus cor palpitet: hyena cor. Int. J. Cardiol. 122, 164-167 (2007).
11. Yang GQ, Chen JS, Wen ZM et al. The role of selenium in Keshan disease. Adv. Nutr. Res. 6, 203-231 (1984).
12. Weber KT. A Quebec quencher. Cardiovasc. Res. 40, 423-425 (1998). (Pubitemid 28557279)
13. Allard ML, Jeejeebhoy KN, Sole MJ. The management of conditioned nutritional requirements in heart failure. Heart Fail. Rev. 11, 75-82 (2006). (Pubitemid 43994886)
14. Sole MJ, Jeejeebhoy KN. Conditioned nutritional requirements: therapeutic relevance to heart failure. Herz 27, 174-178 (2002). (Pubitemid 34309401)
15. Weber KT, Weglicki WB, Simpson RU. Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium. Cardiovasc. Res. 81, 500-508 (2009).
16. Witte KK, Clark AL, Cleland JG. Chronic heart failure and micronutrients. J. Am. Coll. Cardiol. 37, 1765-1774 (2001). (Pubitemid 32499957)
17. Ypenburg C, Sieders A, Bleeker GB et al. Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy. Am. Heart J. 154, 1160-1165 (2007). (Pubitemid 350161774)
18. Anand I, Chandrashekhan Y, De Giuli F et al. Acute and chronic effects of propionyl-l-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure. Cardiovasc. Drugs Ther. 12, 291-299 (1998). (Pubitemid 28416496)
19. Pfitzenmeyer P, Guilland JC, dAthis P, Petit-Marnier C, Gaudet M. Thiamine status of elderly patients with cardiac failure including the effects of supplementation. Int. J. Vitam. Nutr. Res. 64, 113-118 (1994). (Pubitemid 2111240)
20. Shimon I, Almog S, Vered Z et al. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am. J. Med. 98, 485-490 (1995).
21. Jeejeebhoy F, Keith M, Freeman M et al. Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Am. Heart J. 143, 1092-1100 (2002). (Pubitemid 34666903)
22. Witte KK, Nikitin NP, Parker AC et al. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur. Heart J. 26, 2238-2244 (2005). (Pubitemid 41541386)
23. Alexander CS. Idiopathic heart disease. I. Analysis of 100 cases, with special reference to chronic alcoholism. Am. J. Med. 41, 213-228 (1966).
24. Ikram H, Williamson HG, Won M, Crozier IG, Wells EJ. The course of idiopathic dilated cardiomyopathy in New Zealand. Br. Heart J. 57, 521-527 (1987). (Pubitemid 17082525)
25. Hanninen SA, Darling PB, Sole MJ, Barr A, Keith ME. The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. J. Am. Coll. Cardiol. 47, 354-361 (2006). (Pubitemid 43063254)
26. Keith ME, Walsh NA, Darling PB et al. B-vitamin Deficiency in hospitalized patients with heart failure. J. Am. Diet Assoc. 109, 1406-1410 (2009).
27. Arsenian MA. Carnitine and its derivatives in cardiovascular disease. Prog. Cardiovasc. Dis. 40, 265-286 (1997).
28. Schonekess BO, Allard MF, Lopaschuk GD. Propionyl l-carnitine improvement of hypertrophied rat heart function is associated with an increase in cardiac efficiency. Eur. J. Pharmacol. 286, 155-166 (1995).
29. Nakamura T, Sugihara H, Kinoshita N et al. Serum carnitine concentrations in patients with idiopathic hypertrophic cardiomyopathy: relationship with impaired myocardial fatty acid metabolism. Clin. Sci. 97, 493-501 (1999). (Pubitemid 29473750)
30. Rizos I. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and l-carnitine administration. Am. Heart J. 139, S120-S123 (2000). (Pubitemid 30091776)
31. Neubauer S, Horn M, Cramer M et al. Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 96, 2190-2196 (1997). (Pubitemid 27425822)
32. Gordon A, Hultman E, Kaijser L et al. Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. Cardiovasc. Res. 30, 413-418 (1995).
33. Kohlmeier. Nutrient Metabolism. Academic Press, London, UK (2003).
34. Azuma J, Sawamura A, Awata N. Usefulness of taurine in chronic congestive heart failure and its prospective application. Jpn Circ. J. 56, 95-99 (1992).
35. Schuller-Levis GB, Park E. Taurine: new implications for an old amino acid. FEMS Microbiol. Lett. 226, 195-202 (2003). (Pubitemid 38444940)
36. Sada H, Ban T, Sperelakis N. Action potential duration-stabilizing action of taurine in guinea pig ventricular myocytes. Jpn J. Pharmacol. 70, 303-312 (1996). (Pubitemid 26000504)
37. Sawamura A, Sada H, Azuma J, Kishimoto S, Sperelakis N. Taurine modulates ion influx through cardiac Ca2+ channels. Cell Calcium 11, 251-259 (1990). (Pubitemid 20134355)
38. Sada H, Ban T, Sperelakis N. Kinetic mechanism of Na+ channel depression by taurine in guinea pig ventricular myocytes. Jpn J. Pharmacol. 71, 147-159 (1996). (Pubitemid 26235599)
39. Suleiman MS, Rodrigo GC, Chapman RA. Interdependence of intracellular taurine and sodium in guinea pig heart. Cardiovasc. Res. 26, 897-905 (1992).
40. Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur. J. Heart Fail. 5, 615-619 (2003). (Pubitemid 38043966)
41. Fryer MJ. Rationale for clinical trials of selenium as an antioxidant for the treatment of the cardiomyopathy of Friedreichs ataxia. Med. Hypotheses 58, 127-132 (2002). (Pubitemid 34174421)
42. da Cunha S, Albanesi Filho FM, da Cunha Bastos VL, Antelo DS, Souza MM. Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics. Arq. Bras. Cardiol. 79, 454-465 (2002). (Pubitemid 36367976)
43. Collipp PJ, Chen SY. Cardiomyopathy and selenium deficiency in a two-year-old girl. N. Engl. J. Med. 304, 1304-1305 (1981).
44. Oster O, Prellwitz W, Kasper W, Meinertz T. Congestive cardiomyopathy and the selenium content of serum. Clin. Chim. Acta 128, 125-132 (1983). (Pubitemid 13121802)
45. Reeves WC, Marcuard SP, Willis SE, Movahed A. Reversible cardiomyopathy due to selenium deficiency. J. Parenter. Enteral Nutr. 13, 663-665 (1989). (Pubitemid 20005572)
46. Boldery R, Fielding G, Rafter T, Pascoe AL, Scalia GM. Nutritional deficiency of selenium secondary to weight loss (bariatric) surgery associated with life-threatening cardiomyopathy. Heart Lung Circ. 16, 123-126 (2007). (Pubitemid 46436715)
47. Arroyo M, Laguardia SP, Bhattacharya SK et al. Micronutrients in African-Americans with decompensated and compensated heart failure. Transl. Res. 148, 301-308 (2006). (Pubitemid 44880038)
48. Klevay LM. Cardiovascular disease from copper deficiency - a history. J. Nutr. 130, 489S-492S (2000). (Pubitemid 30073780)
49. Li Y, Wang L, Schuschke DA et al. Marginal dietary copper restriction induces cardiomyopathy in rats. J. Nutr. 135, 2130-2136 (2005). (Pubitemid 41298377)
50. Salehifar E, Shokrzadeh M, Ghaemian A, Aliakbari S, Saeedi Saravi SS. The study of Cu and Zn serum levels in idiopathic dilated cardiomyopathy (IDCMP) patients and its comparison with healthy volunteers. Biol. Trace Elem. Res. 125, 97-108 (2008).
51. Clayton BE. Clinical chemistry of trace elements. Adv. Clin. Chem. 21, 147-176 (1980).
52. Medeiros DM, Davidson J, Jenkins JE. A unified perspective on copper deficiency and cardiomyopathy. Proc. Soc. Exp. Biol. Med. 203, 262-273 (1993). (Pubitemid 23183057)
53. Itoh S, Ozumi K, Kim HW et al. Novel mechanism for regulation of extracellular SOD transcription and activity by copper: role of antioxidant-1. Free Radic. Biol. Med. 46, 95-104 (2009).
54. Chou HT, Yang HL, Tsou SS et al. Status of trace elements in patients with idiopathic dilated cardiomyopathy in central Taiwan. Zhonghua Yi Xue Za Zhi (Taipei) 61, 193-198 (1998).
55. Kosar F, Sahin I, Taskapan C et al. Trace element status (Se, Zn, Cu) in heart failure. Anadolu Kardiyol Derg. 6, 216-220 (2006). (Pubitemid 44390477)
56. Ripa S, Ripa R, Giustiniani S. Are failured cardiomyopathies a zinc-deficit related disease? A study on Zn and Cu in patients with chronic failured dilated and hypertrophic cardiomyopathies. Minerva Med. 89, 397-403 (1998). (Pubitemid 29142265)
57. Topuzoglu G, Erbay AR, Karul AB, Yensel N. Concentrations of copper, zinc, and magnesium in sera from patients with idiopathic dilated cardiomyopathy. Biol. Trace Elem. Res. 95, 11-17 (2003). (Pubitemid 37386643)
58. Riggs JE, Klingberg WG, Flink EB et al. Cardioskeletal mitochondrial myopathy associated with chronic magnesium deficiency. Neurology 42, 128-130 (1992).
59. Weglicki WB, Mak Iu T, Chmielinska JJ et al. The role of magnesium deficiency in cardiovascular and intestinal inflammation. Magnes. Res. 23, 199-206 (2010).
60. McNair WP, Ku L, Taylor MR et al. SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation 110, 2163-2167 (2004). (Pubitemid 39372495)
61. Greenlee PR, Anderson JL, Lutz JR, Lindsay AE, Hagan AD. Familial automaticity-conduction disorder with associated cardiomyopathy. West J. Med. 144, 33-41 (1986). (Pubitemid 16069503)
62. Hegde N, Rich MW, Gayomali C. The cardiomyopathy of iron deficiency. Tex. Heart Inst. J. 33, 340-344 (2006). (Pubitemid 44683429)
63. Alvares JF, Oak JL, Pathare AV. Evaluation of cardiac function in iron deficiency anemia before and after total dose iron therapy. J. Assoc. Physicians India 48, 204-206 (2000).
64. Mahfoud F, Kindermann I, Kindermann M, Ukena C, Bohm M. [Comorbidity: anemia and heart failure]. Dtsch Med. Wochenschr. 134, 825-830 (2009).
65. Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog. Biophys. Mol. Biol. 92, 39-48 (2006). (Pubitemid 43831966)
66. Zittermann A, Schleithoff SS, Tenderich G et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J. Am. Coll. Cardiol. 41, 105-112 (2003). (Pubitemid 36044411)
67. Chhokar VS, Sun Y, Bhattacharya SK et al. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation 111, 871-878 (2005). (Pubitemid 40279888)
68. Frustaci A, Magnavita N, Chimenti C et al. Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction. J. Am. Coll. Cardiol. 33, 1578-1583 (1999).
69. Wester PO. Trace elements in human myocardial infarction determined by neutron activation analysis. Acta Med. Scand. 178, 765-788 (1965).
70. Harinstein ME, Berliner JI, Shah SJ, Taegtmeyer H, Gheorghiade M. Normalization of ejection fraction and resolution of symptoms in chronic severe heart failure is possible with modern medical therapy: clinical observations in 11 patients. Am. J. Ther. 15, 206-213 (2008).
71. Katz AM. Is the failing heart an energy-starved organ? J. Card. Fail. 2, 267-272 (1996).
72. Sinatra ST. Metabolic cardiology: an integrative strategy in the treatment of congestive heart failure. Altern. Ther. Health Med. 15, 44-52 (2009).
73. Rieck J, Halkin H, Almog S et al. Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers. J. Lab. Clin. Med. 134, 238-243 (1999). (Pubitemid 29423096)
74. Yui Y, Itokawa Y, Kawai C. Furosemide-induced thiamine deficiency. Cardiovasc. Res. 14, 537-540 (1980). (Pubitemid 11226350)
75. Tsujino T, Nakao S, Wakabayashi K et al. Loop diuretic precipitated beriberi in a patient after pancreaticoduodenectomy: a case report. Am. J. Med. Sci. 334, 407-409 (2007). (Pubitemid 351339277)
76. Michel MC, Beckeringh JJ, Ikezono K, Kretsch R, Brodde OE. Lymphocyte b 2-adrenoceptors mirror precisely b 2-adrenoceptor, but poorly b 1-adrenoceptor changes in the human heart. J. Hypertens. Suppl. 4, S215-S218 (1986).