Rationale for clinical trials of selenium as an antioxidant for the treatment of the cardiomyopathy of Friedreich's ataxia

Medical Hypotheses

Volumn 58, Issue 2, 2002, Pages 127-132

  Fryer, M J ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; GLUTATHIONE PEROXIDASE; SELENIUM; TRACE ELEMENT;

ANIMAL MUSCULAR DYSTROPHY; ARTICLE; CARDIOMYOPATHY; CONGESTIVE CARDIOMYOPATHY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; FRIEDREICH ATAXIA; HEART DILATATION; HISTOPATHOLOGY; HUMAN; LIPID PEROXIDATION; MITOCHONDRION; OXIDATION; PRIORITY JOURNAL; SELENIUM DEFICIENCY;

ANIMALIA;

EID: 0036179037     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2001.1474     Document Type: Article

References (43)

1. Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion
2. Frataxin gene of Friedreich's ataxia is targeted to mitochondria
3. The neurologic syndrome of vitamin E deficiency: A significant cause of ataxia
4. Vitamin E and neurological function: Lessons from patients with abetalipoproteinaemia
5. Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein
6. Regulation of mitochondrial iron accumulation by YFH1p, a putative homolog of frataxin
7. Detection of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria
8. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia
9. Mitochondrial respiratory chain disorders II: Neurodegenerative disorders and nuclear gene defects
10. Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia
11. Effect of idebenone on cardiomyopathy in Friedreich's ataxia: A preliminary study
12. Current status of iron chelation therapy with deferoxamine
13. 2 injury in adult cardiomyocytes
14. Survival in patients with amyotrophic lateral sclerosis, treated with an array of antioxidants
15. Oxidative stress in patients with Friedreich ataxia
16. Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: A cooperative study in Europe, Australia and New Zealand
17. U-78517F: A potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischaemia
18. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury
19. The importance of selenium to human health
20. Some selenium responses in the rat not related to vitamin E
21. Effects of selenium deficiency on vitamin E metabolism in rats
22. Requirement for selenium (as selenite) and vitamin E (as α-tocopherol) in weaned pigs. III: The effect on the development of the VESD syndrome of varying selenium levels in a low-tocopherol diet
23. Ultrastructural alterations in nutritional cardiomyopathy of selenium: Vitamin E deficient swine. I: Fiber lesions
24. Morphological and aetiological studies of dietetic microangiopathy in pigs ('mulberry heart')
25. Sudden death in calves associated with acute myocardial degeneration and selenium deficiency
26. Selenium responsive diseases of animals in New Zealand
27. Selenium in animal health and disease
28. Selenium deficiency in total parenteral nutrition
29. Selenium in human health and disease with emphasis on those aspects peculiar to New Zealand
30. Studies on the relations of selenium and Keshan disease
31. Observations on effect of sodium selenite in prevention of Keshan disease
32. Epidemiologic studies on the etiologic relationship of selenium and Keshan disease
33. Selenium in the heart of China
34. Micronutrient status in patients receiving home parenteral nutrition
35. An Occidental case of cardiomyopathy and selenium deficiency
36. Selenium deficiency and fatal cardiomyopathy in a patient on home parenteral nutrition
37. Pathology of the heart in Friedreich's ataxia: Review of the literature and report of one case
38. The cardiomyopathy of Friedreich's ataxia: Morphological observations in 3 cases
39. Abnormalities of glutathione peroxidase and glutathione reductase in four patients with Friedreich's disease
40. Abnormalities of antioxidant metabolism in a case of Friedreich's disease