Lack of association of the apoe ε4 allele with the risk of obstructive sleep apnea: Meta-analysis and meta-regression

Sleep

Volumn 32, Issue 11, 2009, Pages 1507-1511

  Thakre, Tushar P ^a,b   Mamtani, Manju R ^a   Kulkarni, Hemant ^a  

^a Lata Medical Research Foundation   (India)

^b UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

Author keywords

APOE; Apolipoprotein E; Epidemiology; Genetic; Obstructive sleep apnea

Indexed keywords

APOLIPOPROTEIN E EPSILON 4; APOLIPOPROTEIN E4; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONFIDENCE INTERVAL; CONTROL GROUP; CONTROLLED STUDY; EFFECT SIZE; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GEOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP APNEA SYNDROME;

EID: 70649103102     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.1093/sleep/32.11.1507     Document Type: Article

References (38)

1. Bradley TD, Floras JS. Obstructive sleep apnoea and its cardiovascular consequences. Lancet 373:82-93.
2. Noda A, Okada T, Yasuma F, Sobue T, Nakashima N, Yokota M. Prognosis of the middle-aged and aged patients with obstructive sleep apnea syndrome. Psychiatry Clin Neurosci 52:79-85.
3. Palomaki H, Partinen M, Erkinjuntti T, Kaste M. Snoring, sleep apnea syndrome, and stroke. Neurology 42:75-81; discussion 82.
4. Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc 79:1036-1046
5. Redline S, Young T. Epidemiology and natural history of obstructive sleep apnea. Ear Nose Throat J 72:20-1, 24-26
6. Young T. Analytic epidemiology studies of sleep disordered breathing - what explains the gender difference in sleep disordered breathing? Sleep 16:S1-2.
7. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230-1235
8. Carmelli D, Colrain IM, Swan GE, Bliwise DL. Genetic and environmental influences in sleep-disordered breathing in older male twins. Sleep 27:917-922
9. Ohayon MM. From wakefulness to excessive sleepiness: what we know and still need to know. Sleep Med Rev 12:129-141
10. Rubin AE, Polotsky VY, Balbir A, et al. Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains. Am J Respir Crit Care Med 168:1520-1527
11. Cosentino FI, Bosco P, Drago V, et al. The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea. Sleep Med 9:831-839
12. Craig D, Hart DJ, Passmore AP. Genetically increased risk of sleep disruption in Alzheimer's disease. Sleep 29:1003-1007
13. Foley DJ, Masaki K, White L, Redline S. Relationship between apolipoprotein E epsilon4 and sleep-disordered breathing at different ages. JAMA 286:1447-1448
14. Gottlieb DJ, DeStefano AL, Foley DJ, et al. APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health Study. Neurology 63:664-668
15. Gozal D, Capdevila OS, Kheirandish-Gozal L, Crabtree VM. APOE epsilon 4 allele, cognitive dysfunction, and obstructive sleep apnea in children. Neurology 69:243-249
16. Kadotani H, Kadotani T, Young T, et al. Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. JAMA 285:2888-2890
17. Larkin EK, Patel SR, Redline S, Mignot E, Elston RC, Hallmayer J. Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak. Genet Epidemiol 30:101-110
18. Saarelainen S, Lehtimaki T, Kallonen E, Laasonen K, Poussa T, Nieminen MM. No relation between apolipoprotein E alleles and obstructive sleep apnea. Clin Genet 53:147-148
19. Cosentino S, Scarmeas N, Helzner E, et al. APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease. Neurology 70:1842-9.
20. Mahley RW, Huang Y. Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurol Scand Suppl 185:8-14.
21. Burt TD, Agan BK, Marconi VC, et al. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A 105:8718-8723
22. Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function-from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res 2008 Dec 22 [epub ahead of print]
23. Kalra M, Pal P, Kaushal R, et al. Association of ApoE genetic variants with obstructive sleep apnea in children. Sleep Med 9:260-265
24. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 7:177-188
25. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539-1558
26. Egger M, Smith GD. Bias in location and selection of studies. BMJ 316:61-66
27. Higgins JP, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med 23:1663-1682
28. Thompson SG, Higgins JP. Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit? Lancet 365:341-346
29. Kheirandish L, Row BW, Li RC, Brittian KR, Gozal D. Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits. Sleep 28:1412-1417
30. Robertson J, Curley J, Kaye J, Quinn J, Pfankuch T, Raber J. ApoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice. Neurobiol Aging 26:637-643
31. Jia LY, Tam PO, Chiang SW, et al. Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese. Mol Vis 15:89-98.
32. Kao WT, Yen YC, Lung FW. The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles. Lipids Health Dis 7:20.
33. Peng DQ, Zhao SP, Nie S, Li J. Gene-gene interaction of PPARgamma and ApoE affects coronary heart disease risk. Int J Cardiol 92:257-263
34. Sorli JV, Corella D, Frances F, et al. The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population. Clin Chim Acta 366:196-203.
35. Saarelainen S, Lehtimaki T, Nikkila M, Solakivi T, Nieminen MM, Jaakkola O. Association between apolipoprotein E alleles and autoantibodies against oxidised low-density lipoprotein. Clin Chem Lab Med 38:477-478
36. Spira AP, Blackwell T, Stone KL, et al. Sleep-disordered breathing and cognition in older women. J Am Geriatr Soc 56:45-50.
37. Westbrook PR, Levendowski DJ, Cvetinovic M, et al. Description and validation of the apnea risk evaluation system: a novel method to diagnose sleep apnea-hypopnea in the home. Chest 128:2166-2175
38. Infante J, Sanz C, Fernandez-Luna JL, Llorca J, Berciano J, Combarros O. Gene-gene interaction between interleukin-6 and interleukin-10 reduces AD risk. Neurology 63:1135-1136