Evaluation of rosa damascena mouthwash in the treatment of recurrent aphthous stomatitis: A randomized, double-blinded, placebo-controlled clinical trial

Quintessence International

Volumn 42, Issue 6, 2011, Pages 483-491

  Hoseinpour, Hassan ^a   Peel, Sean A F ^b   Rakhshandeh, Hassan ^c   Forouzanfar, Ali ^a   Taheri, Morteza ^a   Rajabi, Omid ^a   Saljoghinejad, Mostafa ^a   Sohrabi, Keyvan ^a,d  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TORONTO   (Canada)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Clinical trial; Placebo; Recurrent aphthous stomatitis; Rosa damascena

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; MOUTHWASH; PLACEBO; PLANT EXTRACT;

ADULT; APHTHOUS STOMATITIS; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; PAIN ASSESSMENT; PATHOLOGY; PHYTOTHERAPY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; ROSE; TREATMENT OUTCOME; WOUND HEALING;

ADULT; ANALGESICS; ANTI-INFLAMMATORY AGENTS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MOUTHWASHES; PAIN MEASUREMENT; PHYTOTHERAPY; PLACEBOS; PLANT EXTRACTS; RECURRENCE; ROSA; STOMATITIS, APHTHOUS; TREATMENT OUTCOME; WOUND HEALING; YOUNG ADULT;

EID: 80053089979     PISSN: 00336572     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Barrons RW. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm 2001;58:41-50.
2. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis:A consensus approach. J Am Dent Assoc 2003;134:200-207.
3. Woo SB, Sonis ST. Recurrent aphthous ulcers:A review of diagnosis and treatment. J Am Dent Assoc 1996;127:1202-1213.
4. Ship JA. Recurrent aphthous stomatitis. An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;81:141-147.
5. Babaie A, Tabaei-Aghdaei SR, Khosh-Khui M, et al. Microsatellite analysis of Damask rose (Rosa damascena Mill.) accessions from various regions in Iran reveals multiple genotypes. BMC Plant Biol 2007;7:12.
6. Boulos L. Medicinal Plants of North Africa. Algonac, Michigan: Reference Publications, 1983:286.
7. Sanagustin F. Contribution a l'etude de la mati`ere m`edicale traditionnelle chez les herboristes d'Alep. Bulletin Etudes Orientales 1983;35:65-112.
8. Avesina AA. Law in Medicine. Tehran, Ministry of Guidance Publication, 1990.
9. Talib WH, Mahasneh AM. Antimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicine. Molecules 2010;15:1811-1824.
10. Achuthan CR, Babu BH, Padikkala J. Antioxidant and hepatoprotective effects of Rosa damascena. Pharm Biol 2003;41:357-361.
11. Kwon EK, Lee DY, Lee H, et al. Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme: A reductase and angiotensin I-converting enzyme. J Agric Food Chem 2010;58:882-886.
12. Hosseini M, Rakhshandah H, Shafieenic R, Dolati K. Analgesic effect of Rosa damascena on mice. Abstract Book of 16th Iranian Congress of Physiology and Pharmacology. Tarbiat Modarres University: Tehran, 2003,167.
13. Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iranian J Pharm Res 2010;9:163-168.
14. Maleev A, Neshev G, Stoianov S, Sheĭkov N. The ulcer protective and anti-inflammatory effect of Bulgarian rose oil [in Bulgarian]. Eksp Med Morfol 1972;11:55-60.
15. WHO. Quality Control Methods for Medicinal Plant Materials. Geneva: World Health Organization, 1998.
16. Makkar HPS, Blümmel M, Borowy NK, Becker K. Gravimetric determination of tannins and their correlations with chemical and protein precipitation methods. J Sci Food Agric 1993;61:161-165.
17. Barker G, Loftus L, Cuddy P, Barker B. The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis. Oral Surg Oral Med Oral Pathol 1991;71:288-293.
18. Meng W, Dong Y, Liu J, et al. A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: A randomized, placebo controlled, blinded, multicenter clinical trial. Trials 2009;10:30.
19. Delavarian Z, Orafai H, Molashahi L, Pakfetrat A. The effect of topical sucralfate suspension on oral aphthae. J Dent Tehran Uni Med Sci 2007;4;72-77.
20. WHO. National Policy on Traditional Medicine and Regulation of Herbal Medicines-Report of a WHO Global Survey, 2005. http://apps.who.int/medicinedocs/en/d/Js7916e/. Accessed 19 January 2011.
21. WHO. Traditional medicine. Fact sheet Number 134, 2008.
22. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 2001;109(suppl):69-75.
23. Babaee N, Mansourian A, Momen-Heravi F, Moghadamnia A, Momen-Beitollahi J. The efficacy of a paste containing Myrtus communis (Myrtle) in the management of recurrent aphthous stomatitis:A randomized controlled trial. Clin Oral Investig 2010;14:65-70.
24. Regezi JA, Sciubba JJ. Oral Pathology: Clinical-Pathological Correlations. Philadelphia: WB Saunders, 1989:47.
25. Cimen MY, Kaya TI, Eskandari G, Tursen U, Ikizoglu G, Atik U. Oxidant/antioxidant status in patients with recurrent aphthous stomatitis. Clin Exp Dermatol 2003;28:647-650.
26. Schiber A, Mihalev K, Berardini N, Mollov P, Carle R. Flavonol glycosides from distilled petals of Rosa damascena Mill. Z Naturforsch C 2005;60:379-384.
27. Ulusoy S, Boşgelmez-Tinaz G, Seçilmiş-Canbay H. Tocopherol, carotene, phenolic contents and antibacterial properties of rose essential oil, hydrosol and absolute. Curr Microbiol 2009;59:554-558.
28. Ozkan G, Sagdic O, Baydar NG, Baydar H. Antioxidant and antibacterial activities of Rosa damascena flower extracts. Food Sci Technol Int 2004;10:277-281.
29. Arndt K, Bowers K. Manual of Dermatologic Therapeutics, ed 6. Philadelphia: Lippincott Williams & Wilkins, 2002.