Dendritic coding of multiple sensory inputs in single cortical neurons in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 37, 2011, Pages 15420-15425

  Varga, Zsuzsanna ^a   Jia, Hongbo ^a   Sakmann, Bert ^a   Konnerth, Arthur ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cortical circuits; Excitatory synapse in vivo; Mouse barrel cortex

Indexed keywords

ADRENAL CORTEX; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL ACTIVITY; CELL STIMULATION; CONTROLLED STUDY; DENDRITIC CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIBRISSA;

ANIMALS; CALCIUM; CEREBRAL CORTEX; DENDRITES; DENDRITIC SPINES; ELECTRIC STIMULATION; MICE; MICE, INBRED C57BL; PHYSICAL STIMULATION; SENSATION; TIME FACTORS; VIBRISSAE;

MAMMALIA;

EID: 80053075846     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112355108     Document Type: Article

References (42)

1. Cajal SRY (1994) Histology of the Nervous System of Man and Vertebrates (Oxford University Press, London).
2. Lichtman JW, Livet J, Sanes JR (2008) A technicolour approach to the connectome. Nat Rev Neurosci 9:417-422.
3. Denk W, Horstmann H (2004) Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure. PLoS Biol 2:e329.
4. DeFalco J, et al. (2001) Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science 291:2608-2613. (Pubitemid 32249686)
5. Feldmeyer D, Lübke J, Sakmann B (2006) Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats. J Physiol 575:583-602. (Pubitemid 44270183)
6. Lefort S, Tomm C, Floyd Sarria JC, Petersen CC (2009) The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. Neuron 61:301-316.
7. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K (2005) Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci 8:1263-1268. (Pubitemid 43348147)
8. Nikolenko V, Poskanzer KE, Yuste R (2007) Two-photon photostimulation and imaging of neural circuits. Nat Methods 4:943-950. (Pubitemid 350042384)
9. Petreanu L, Mao T, Sternson SM, Svoboda K (2009) The subcellular organization of neocortical excitatory connections. Nature 457:1142-1145.
10. Shepherd GM, Svoboda K (2005) Laminar and columnar organization of ascending excitatory projections to layer 2/3 pyramidal neurons in rat barrel cortex. J Neurosci 25:5670-5679. (Pubitemid 40847879)
11. Jia H, Rochefort NL, Chen X, Konnerth A (2010) Dendritic organization of sensory input to cortical neurons in vivo. Nature 464:1307-1312.
12. Ohki K, Reid RC (2007) Specificity and randomness in the visual cortex. Curr Opin Neurobiol 17:401-407. (Pubitemid 47531950)
13. Priebe NJ, Ferster D (2010) Neuroscience: Each synapse to its own. Nature 464:1290-1291.
14. Hubel DH, Wiesel TN (1962) Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J Physiol 160:106-154.
15. Celikel T, Sakmann B (2007) Sensory integration across space and in time for decision making in the somatosensory system of rodents. Proc Natl Acad Sci USA 104:1395-1400. (Pubitemid 46184015)
16. Woolsey TA, Van der Loos H (1970) The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units. Brain Res 17:205-242.
17. Armstrong-James M, Callahan CA (1991) Thalamo-cortical processing of vibrissal information in the rat. II. Spatiotemporal convergence in the thalamic ventroposterior medial nucleus (VPm) and its relevance to generation of receptive fields of S1 cortical "barrel" neurones. J Comp Neurol 303:211-224.
18. Armstrong-James M, Callahan CA, Friedman MA (1991) Thalamo-cortical processing of vibrissal information in the rat. I. Intracortical origins of surround but not centre-receptive fields of layer IV neurones in the rat S1 barrel field cortex. J Comp Neurol 303:193-210.
19. Armstrong-James M, Fox K, Das-Gupta A (1992) Flow of excitation within rat barrel cortex on striking a single vibrissa. J Neurophysiol 68:1345-1358.
20. Brecht M, Sakmann B (2002) Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex. J Physiol 543:49-70. (Pubitemid 34947296)
21. De Kock CP, Bruno RM, Spors H, Sakmann B (2007) Layer- and cell-type-specific suprathreshold stimulus representation in rat primary somatosensory cortex. J Physiol 581:139-154. (Pubitemid 46712033)
22. Hirata A, Castro-Alamancos MA (2008) Cortical transformation of wide-field (multiwhisker) sensory responses. J Neurophysiol 100:358-370.
23. Manns ID, Sakmann B, Brecht M (2004) Sub- and suprathreshold receptive field properties of pyramidal neurones in layers 5A and 5B of rat somatosensory barrel cortex. J Physiol 556:601-622. (Pubitemid 38579010)
24. Moore CI, Nelson SB (1998) Spatio-temporal subthreshold receptive fields in the vibrissa representation of rat primary somatosensory cortex. J Neurophysiol 80:2882-2892. (Pubitemid 29029220)
25. Wright N, Fox K (2010) Origins of cortical layer V surround receptive fields in the rat barrel cortex. J Neurophysiol 103:709-724.
26. Zhu JJ, Connors BW (1999) Intrinsic firing patterns and whisker-evoked synaptic responses of neurons in the rat barrel cortex. J Neurophysiol 81:1171-1183. (Pubitemid 29272435)
27. Brecht M, Roth A, Sakmann B (2003) Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex. J Physiol 553:243-265. (Pubitemid 37483932)
28. Kleinfeld D, Delaney KR (1996) Distributed representation of vibrissa movement in the upper layers of somatosensory cortex revealed with voltage-sensitive dyes. J Comp Neurol 375:89-108. (Pubitemid 26378146)
29. Petersen CC, Grinvald A, Sakmann B (2003) Spatiotemporal dynamics of sensory responses in layer 2/3 of rat barrel cortex measured in vivo by voltage-sensitive dye imaging combined with whole-cell voltage recordings and neuron reconstructions. J Neurosci 23:1298-1309. (Pubitemid 36258908)
30. Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN (1986) Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature 324:361-364. (Pubitemid 17180109)
31. Jia H, Rochefort NL, Chen X, Konnerth A (2011) In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons. Nat Protoc 6:28-35.
32. Svoboda K, Helmchen F, Denk W, Tank DW (1999) Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo. Nat Neurosci 2:65-73. (Pubitemid 30488942)
33. Theodoridis S, Koutroumbas K (2006) Pattern Recognition (Elsevier, Amsterdam).
34. Chen X, Leischner U, Rochefort NL, Nelken I, Konnerth A (2011) Functional mapping of single spines in cortical neurons in vivo. Nature 475:501-505.
35. Adesnik H, Scanziani M (2010) Lateral competition for cortical space by layer-specific horizontal circuits. Nature 464:1155-1160.
36. Derdikman D, Hildesheim R, Ahissar E, Arieli A, Grinvald A (2003) Imaging spatiotemporal dynamics of surround inhibition in the barrels somatosensory cortex. J Neurosci 23:3100-3105. (Pubitemid 36531949)
37. Fino E, Yuste R (2011) Dense inhibitory connectivity in neocortex. Neuron 69:1188-1203.
38. Schiller J, Major G, Koester HJ, Schiller Y (2000) NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature 404:285-289. (Pubitemid 30163545)
39. Branco T, Häusser M (2010) The single dendritic branch as a fundamental functional unit in the nervous system. Curr Opin Neurobiol 20:494-502.
40. Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J (2009) Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: A new unifying principle. Science 325:756-760.
41. Lübke J, Roth A, Feldmeyer D, Sakmann B (2003) Morphometric analysis of the columnar innervation domain of neurons connecting layer 4 and layer 2/3 of juvenile rat barrel cortex. Cereb Cortex 13:1051-1063. (Pubitemid 37163204)
42. Kerr JN, et al. (2007) Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. J Neurosci 27:13316-13328. (Pubitemid 350220486)