Counterpoint: Is Measuring Sputum Eosinophils Useful in the Management of Severe Asthma? No, Not for the Vast Majority of Patients

Chest

Volumn 139, Issue 6, 2011, Pages 1273-1275

  Peters, Stephen P ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASTHMA; BLOOD; CYTOLOGY; EOSINOPHIL; HUMAN; LEUKOCYTE COUNT; NOTE; PHYSIOLOGY; SPUTUM;

ASTHMA; EOSINOPHILS; HUMANS; LEUKOCYTE COUNT; SPUTUM;

MLCS; MLOWN;

EID: 80053070332     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.11-0627     Document Type: Editorial

References (10)

1. Fahy, JV, Boushey, HA, Lazarus, SC, et al., NHLBI Asthma Clinical Research Network, Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med 163:6 (2001), 1470–1475.
2. Petsky HL, Cates CJ, Lasserson TJ, et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils) [published online ahead of print October 11, 2010]. Thorax doi:10.1136/thx.2010.135574.
3. Moore, WC, Bleecker, ER, Curran-Everett, D, et al., National Heart, Lung, Blood Institute's Severe Asthma Research Program, Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 119:2 (2007), 405–413.
4. Peters, SP, Kunselman, SJ, Icitovic, N, et al., National Heart, Lung, and Blood Institute Asthma Clinical Research Network, Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 363:18 (2010), 1715–1726.
5. van Veen, IH, Ten Brinke, A, Gauw, SA, Sterk, PJ, Rabe, KF, Bel, EH, Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study. J Allergy Clin Immunol 124:3 (2009), 615–617.
6. ten Brinke, A, Zwinderman, AH, Sterk, PJ, Rabe, KF, Bel, EH, “Refractory” eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids. Am J Respir Crit Care Med 170:6 (2004), 601–605.
7. Dente, FL, Bacci, E, Bartoli, ML, et al. Effects of oral prednisone on sputum eosinophils and cytokines in patients with severe refractory asthma. Ann Allergy Asthma Immunol 104:6 (2010), 464–470.
8. Haldar, P, Brightling, CE, Hargadon, B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360:10 (2009), 973–984.
9. Nair, P, Pizzichini, MM, Kjarsgaard, M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 360:10 (2009), 985–993.
10. Hastie, AT, Moore, WC, Meyers, DA, et al., National Heart, Lung, and Blood Institute Severe Asthma Research Program, Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 125:5 (2010), 1028–1036.