Safety and efficacy of micronized tretinoin gel (0.05%) in treating adolescent acne

Journal of Drugs in Dermatology

Volumn 10, Issue 6, 2011, Pages 647-652

  Torok, Helen M ^a   Pillai, Radhakrishan ^b  

^a Trillium Creek Dermatology and Spa   (United States)

^b Dow Pharmaceutical Sciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYL PEROXIDE; EXCIPIENT; MICROSPHERE; RETINOIC ACID;

ACNE; BURN; DEGRADATION; DERMATITIS; DERMIS; DISEASE SEVERITY; DRUG DEGRADATION; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG SAFETY; DRUG STABILITY; DRUG TOLERABILITY; EPIDERMIS; ERYTHEMA; GEL; HUMAN; HUMIDIFIER; LIFESTYLE; MOLECULE; PARTICLE SIZE; PEDIATRICS; PROFESSIONAL PRACTICE; REVIEW; SKIN; SKIN INFLAMMATION; SKIN IRRITATION;

ACNE VULGARIS; ADMINISTRATION, CUTANEOUS; ADOLESCENT; ANTI-BACTERIAL AGENTS; BENZOYL PEROXIDE; CHILD; DERMATOLOGIC AGENTS; DRUG STABILITY; DRUG THERAPY, COMBINATION; GELS; HUMANS; KERATOLYTIC AGENTS; PARTICLE SIZE; TRETINOIN;

EID: 80053059541     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

1. Chen WC, Sass JO, Seltmann H, Nau H, Orfanos CE, Zouboulis CC. Biological effect and metabolism of 9-cis-retinoic acid and its metabolite 9,13-di-cis-retinoic acid in HaCaT keratinocytes in vitro: Comparison with all- trans-retinoic acid. Arch Dermatol Res. 2000;292:612-620. (Pubitemid 32112969)
2. Millikan LE. The rationale for using a topical retinoid for inflammatory acne. Am J Clin Dermatol. 2003;4:75-80. (Pubitemid 36259516)
3. Tsukada M, Schroder M, Roos TC, Chandraratna RA, Reichert U, Merk HF, et al. 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol. 2000;115:321-327. (Pubitemid 30637206)
4. Leyden JJ, Shalita AR. Rational therapy for acne vulgaris: An update on topical treatment. J Am Acad Dermatol. 1986;15:907-915. (Pubitemid 17170798)
5. Kligman AM, Mills OH, McGinley KJ, Leyden JJ. Acne therapy with tretinoin in combination with antibiotics. Acta Derm Venereol Suppl (Stockh). 1975;74:111-115.
6. Leyden JJ, Grossman R, Nighland M. Cumulative irritation potential of topical retinoid formulations. J Drugs Dermatol. 2008 Aug;7(8 Suppl):s14-18.
7. Quigley JW, Bucks DAW. Reduced skin irritation with tretinoin containing polyolprepolymer-2, a new topical tretinoin delivery system: A summary of preclinical and clinical investigations J Am Acad Dermatol. 1998, 38 (4): s5-10.
8. Rolland A, Wagner N, Chatelus A, Shroot B, Schaefer H: Site-specific drug delivery to pilosebaceous structures using polymeric microspheres. Pharm Res. 1993; 10:1738-1744. (Pubitemid 24000358)
9. Russel J. Topical therapy for acne. American academy of family physicians, http://www.aafp.org /afp/20000115/357.html (2000).
10. Tabbakhian M, Sharifian A, Shatalebi MA. Preparation and in vitro characterization of tretinoin-containing microspheres suited for dermatological preparations. Res Pharma Sci. 2008; 3(2): 31-40.
11. Erden N, Celebi N. Factors influencing release of salbutamol sulphate from poly (lactide-co-glycolide) microspheres prepared by water-in-oil-in-water emulsion technique. Int J Pharm. 1996;137:57-66. (Pubitemid 26238512)
12. Thielitz A, Gollnick H. Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol. 2008;9(6):369-81.
13. Zaenglein AL, Thiboutot DM. Expert Committee Recommendations for Acne Management. Pediatrics. 2006;118:1188-1199. (Pubitemid 46090063)
14. Chu I, Dick D, Bronaugh R, Tryphonas L. Food Chem Toxicol. 1996; 34:267-276.
15. Lampen P, Pittermann W, Heise HM, et al. Penetration studies of vitamin E acetate applied from cosmetic formulations to the stratum corneum of an in vitro model using quantification by tape stripping, UV spectroscopy, and HPLC. J Cosmet Sci. 2003; 54:119-131. (Pubitemid 36618643)
16. Toll R, Jacobi U, Richter H, et al. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol. 2004;123:168-176. (Pubitemid 38833478)
17. Laquieze S, Czernielewski J, Rueda MJ. Beneficial effect of a moisturizing cream as adjunctive treatment to oral isotretinoin or topical tretinoin in the management of acne. J Drugs Dermatol. 2006; 5(10):985-990.
18. Yan AC. Current concepts in acne management. Adolesc Med Clin. 2006;17(3):613-637. (Pubitemid 44499171)
19. Nyirady J, Camelle L, Yusuf, M, et al. The stability of tretinoin in tretinion gel microsphere 0.1%. Cutis. 2002;70:295-298. (Pubitemid 41750803)
20. Nighland M, Yusuf M, Wisniewski S, et al. The effect of simulated solar UV irradiation on tretinoin in tretinoin gel microsphere 0.1% and tretinoin gel 0.025%. Cutis. 2006:77(5):313-316. (Pubitemid 43845324)
21. Skelly JP, Shah VP, Maibacj HI, Guy RH, Webster RC, Flynn GL, Yacobi A. FDA and AAPS report of the workshop on principles and practices of in vitro percutaneous penetration studies: relevance to bioavailability and bioequivalence. Pharm Res. 1987; 4:265-267. (Pubitemid 17110406)
22. Del Rosso JQ, Pillai, R, Moore R. Absence of degradation of tretinoin when benzoyl peroxide is combined with an optimized formulation of tretinoin gel 0.05%. J Clin Aesth Dermatol 2010; 3 (10): 20-22.
23. Piggott, CDS, Eichenfield LF. Overcoming the challenges of pediatric acne [Clinical Focus] Practical Dermatology. 2010, April;17-18.