Interleukin-10 genotypes of the -1087 single nucleotide polymorphism influence sp1 expression in periodontitis lesions

Journal of Periodontology

Volumn 82, Issue 9, 2011, Pages 1376-1382

  Larsson, Lena ^a   Thorbert Mros, Sara ^a   Rymo, Lars ^b   Berglundh, Tord ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

B cells; Cytokine; Gene expression; Transcription factor

Indexed keywords

ADENINE; GUANINE; INTERLEUKIN 10; MESSENGER RNA; TRANSCRIPTION FACTOR SP1;

ADULT; AGED; ALVEOLAR BONE LOSS; ARTICLE; B LYMPHOCYTE; CHRONIC PERIODONTITIS; FEMALE; GENETICS; GENOTYPE; GINGIVA; GINGIVA BLEEDING; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; MIDDLE AGED; PATHOLOGY; PERIODONTAL POCKET; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION;

ADENINE; ADULT; AGED; ALVEOLAR BONE LOSS; B-LYMPHOCYTES; CHRONIC PERIODONTITIS; FEMALE; GENOTYPE; GINGIVA; GINGIVAL HEMORRHAGE; GUANINE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; MALE; MIDDLE AGED; PERIODONTAL POCKET; POLYMORPHISM, SINGLE NUCLEOTIDE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 80053034942     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2011.100623     Document Type: Article

References (33)

1. Berglundh T, Donati M. Aspects of adaptive host response in periodontitis. J Clin Periodontol 2005;32 (Suppl. 6):87-107. (Pubitemid 41391059)
2. Berglundh T, Donati M, Zitzmann N. B cells in periodontitis: Friends or enemies? Periodontol 2000 2007; 45:51-66.
3. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:2081-2095.
4. Borish L. IL-10: Evolving concepts. J Allergy Clin Immunol 1998;101:293-297. (Pubitemid 28146344)
5. Lalani I, Bhol K, Ahmed AR. Interleukin-10: Biology, role in inflammation and autoimmunity. Ann Allergy Asthma Immunol 1997;79:469-483.
6. Beebe AM, Cua DJ, de Waal Malefyt R. The role of interleukin-10 in autoimmune disease: Systemic lupus erythematosus (SLE) andmultiple sclerosis (MS). Cytokine Growth Factor Rev 2002;13:403-412.
7. Burdin N, Rousset F, Banchereau J. B-cell-derived IL-10: Production and function. Methods 1997;11: 98-111. (Pubitemid 27207921)
8. Llorente L, Richaud-Patin Y, Wijdenes J, et al. Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus. Eur Cytokine Netw 1993;4:421-427. (Pubitemid 24062020)
9. Llorente L, Richaud-Patin Y, Fior R, et al. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. A potential mechanism of B lymphocyte hyperactivity and autoimmunity. Arthritis Rheum 1994;37:1647-1655.
10. Mongan AE, Ramdahin S, Warrington RJ. Interleukin-10 response abnormalities in systemic lupus erythematosus. Scand J Immunol 1997;46:406-412. (Pubitemid 27431864)
11. Berglundh T, Donati M, Hahn-Zoric M, Hanson LA, Padyukov L. Association of the -1087 IL 10 gene polymorphism with severe chronic periodontitis in Swedish Caucasians. J Clin Periodontol 2003;30:249-254. (Pubitemid 38011199)
12. Donati M, Liljenberg B, Padyukov L, Berglundh T. Local expression of interleukin-10 and mCD14 in relation to the -1087 IL-10 and -159 CD14 gene polymorphisms in chronic periodontitis. J Periodontol 2008;79:517-524.
13. Larsson L, Rymo L, Berglundh T. Sp1 binds to the G allele of the-1087 polymorphism in the IL-10 promoter and promotes IL-10 mRNA transcription and protein production. Genes Immun 2010;11:181-187.
14. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997;24:1-8. (Pubitemid 27050850)
15. Chiang BT, Liu YW, Chen BK, Wang JM, Chang WC. Direct interaction of C/EBPdelta and Sp1 at the GCenriched promoter region synergizes the IL-10 gene transcription in mouse macrophage. J Biomed Sci 2006;13:621-635.
16. Courey AJ, Tjian R. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 1988;55:887-898.
17. Ainbinder E, Revach M, Wolstein O, Moshonov S, Diamant N, Dikstein R. Mechanism of rapid transcriptional induction of tumor necrosis factor alpharesponsive genes by NF-kappaB. Mol Cell Biol 2002; 22:6354-6362.
18. Jiang NY, Woda BA, Banner BF, Whalen GF, Dresser KA, Lu D. Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev 2008;17:1648-1652.
19. Kanai M, Wei D, Li Q, et al. Loss of Krüppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. Clin Cancer Res 2006;12:6395-6402. (Pubitemid 44799710)
20. Kang SH, Brown DA, Kitajima I, et al. Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotor. J Biol Chem 1996; 271:7330-7335. (Pubitemid 26106998)
21. Padyukov L, Hahn-Zoric M, Lau YL, Hanson LÅ. Different allelic frequencies of several cytokine genes in Hong Kong Chinese and Swedish Caucasians. Genes Immun 2001;2:280-283. (Pubitemid 33681713)
22. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002;3:research0034.1-research0034.11.
23. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25: 402-408. (Pubitemid 34164012)
24. Allalou A, Wählby C. BlobFinder, a tool for fluorescence microscopy image cytometry. Comput Methods Programs Biomed 2009;94:58-65.
25. Cullinan MP, Westerman B, Hamlet SM, et al. Progression of periodontal disease and interleukin-10gene polymorphism. J Periodontal Res 2008;43:328-333.
26. Brightbill HD, Plevy SE, Modlin RL, Smale ST. A prominent role for Sp1 during lipopolysaccharidemediated induction of the IL-10 promoter in macrophages. J Immunol 2000;164:1940-1951. (Pubitemid 30108749)
27. Chanteux H, Guisset AC, Pilette C, Sibille Y. LPS induces IL-10 production by human alveolar macrophages via MAPKinases-and Sp1-dependent mechanisms. Respir Res 2007;8:71-80.
28. Larsson L, Johansson P, Jansson A, Donati M, Rymo L, Berglundh T. The Sp1 transcription factor binds to the G-allele of the -1087 IL-10 gene polymorphism and enhances transcriptional activation. Genes Immun 2009;10:280-284.
29. Krauss JL, Potempa J, Lambris JD, Hajishengallis G. Complementary Tolls in the periodontium: How periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 2010;52:141-162.
30. Lucas M, Zhang X, Prasanna V, Mosser DM. ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus. J Immunol 2005;175:469-477. (Pubitemid 40884351)
31. Perkins ND, Agranoff AB, Pascal E, Nabel GJ. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Mol Cell Biol 1994;14: 6570-6583. (Pubitemid 24299726)
32. Wang L, Wei D, Huang S, et al. Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin Cancer Res 2003;9:6371-6380. (Pubitemid 38031822)
33. Zhang J, Zhu ZG, Ji J, et al. Transcription factor Sp1 expression in gastric cancer and its relationship to long-term prognosis. World J Gastroenterol 2005;11: 2213-2217. (Pubitemid 40691326)