A mouse is not a man: Should we abandon murine models in critical care research?

Critical Care Medicine

Volumn 39, Issue 10, 2011, Pages 2371-2373

  Wagner, Katja ^a   Calzia, Enrico ^a   Georgieff, Michael ^a   Radermacher, Peter ^a   Wagner, Florian ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

hydrogen sulfide; nonshivering thermogenesis; sheep; suspended animation; swine

Indexed keywords

HYDROGEN SULFIDE;

AIR CONDITIONING; BLOOD PRESSURE; BOVIDS; BRADYCARDIA; CELL RESPIRATION; DISEASE MODEL; EDITORIAL; ENERGY EXPENDITURE; EXPERIMENTAL MOUSE; EXPERIMENTAL PIG; GASTROINTESTINAL TRACT FUNCTION; GLUCOSE OXIDATION; HEART OUTPUT; HEART STROKE VOLUME; HIBERNATION; HUMAN; HYPOTHERMIA; HYPOXIA; INTENSIVE CARE; METABOLISM; MITOCHONDRIAL RESPIRATION; MORTALITY; NONHUMAN; NONSHIVERING THERMOGENESIS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESUSCITATION; SHEEP;

EID: 80053031979     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318224995d     Document Type: Editorial

References (29)

1. Blackstone E, Morrison M, Roth MB: H2S induces a suspended animation-like state in mice. Science 2005; 308:518 (Pubitemid 40570576)
2. Volpato GP, Searles R, Yu B, et al: Inhaled hydrogen sulphide. A rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology 2008; 108: 659-668 (Pubitemid 351440587)
3. Baumgart K, Wagner F, Gröger M, et al: Cardiac and metabolic effects of hypothermia and inhaled hydrogen sulfide in anesthetized and ventilated mice. Crit Care Med 2010; 38:588-595
4. Blackstone E, Roth MB: Suspended animation-like state protects mice from lethal hypoxia. Shock 2007; 27:370-372 (Pubitemid 46594967)
5. Bos EM, Leuvenink HGD, Snijder PM, et al: Hydrogen sulfide-induced hypometabolism prevents renal ischemia/reperfusion injury. J Am Soc Nephrol 2009; 20:1901-1905
6. Faller S, Ryter SW, Choi AM, et al: Inhaled hydrogen sulfide protects against ventilatorinduced lung injury. Anesthesiology 2010; 113:104-115
7. Wagner F, Wagner K, Weber S, et al: Inflammatory effects of hypothermia and inhaled H2S during resuscitated, hyperdynamic murine septic shock. Shock 2011; 35:396-402
8. Haouzi P, Notet V, Chenuel B, et al: H2S induced hypometabolism in mice is missing in sedated sheep. Respir Physiol Neurobiol 2008; 160:109-115 (Pubitemid 350213555)
9. Li J, Zhang G, Cai S, Redington AN: Effect of inhaled hydrogen sulfide on metabolic responses in anesthetized, paralyzed, and mechanically ventilated piglets. Pediatr Crit Care Med 2008; 9:110-112
10. Simon F, Giudici R, Duy CN, et al: Hemodynamic and metabolic effects of hydrogen sulfide during porcine ischemia/reperfusion injury. Shock 2008; 30:359-364
11. Drabek T, Kochanek PM, Stezoski J, et al: Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs. Shock 2011; 35: 67-73
12. Derwall M, Francis RC, Kida K, et al: Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: A proof of concept study on metabolic and vasomotor effects. Crit Care 2011; 15: R51
13. Esechie A, Enkhbaatar P, Traber DL, et al: Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn-and smoke-induced acute lung injury. Br J Pharmacol 2009; 158:1442-1453
14. Osipov RM, Robich MP, Feng J, et al: Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: Comparison of different administration regimens and characterization of the cellular mechanisms of protection. J Cardiovasc Pharmacol 2009; 54:287-297
15. Simon F, Scheuerle A, Grö ger M, et al: Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injury. Shock 2011; 35: 165-163
16. Haouzi P: Murine models in critical care research. Crit Care Med 2011; 39:2290-2293
17. Mortola JP: Hypoxic hypometabolism in mammals. News Physiol Sci 1993; 8:79-82
18. van Marten Lichtenbelt WD, Schrauwen P: Implications of non-shivering thermogenesis for energy balance regulation in humans. Am J Physiol Regul Integr Comp Physiol 2011 Apr 13 [Epub ahead of print]
19. Reade MC, Young JD: Of mice and men (and rats): Implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis. Br J Anaesth 2003; 90:115-118 (Pubitemid 36181951)
20. Bauer M, Reinhart K: From mice and MOF: Rodent models, immune modulation, and outcome in the critically ill. Crit Care Med 2006; 34:912-923
21. Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 1990; 49:186-196 (Pubitemid 20241651)
22. Hollenberg SM: Mouse models of resuscitated shock. Shock 2005; 24(Suppl 1):58-63
23. Traber DL: Expired nitric oxide and shock in high order species. Crit Care Med 1999; 27: 255-256 (Pubitemid 29113527)
24. Barth E, Radermacher P, Thiemermann C, et al: Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock. Crit Care Med 2006; 34:307-313 (Pubitemid 43145605)
25. Rudiger A, Singer M: Mechanisms of sepsisinduced cardiac dysfunction. Crit Care Med 2007; 35:1599-1608
26. Belcher E, Mitchell J, Evans T: Myocardial dysfunction in sepsis: No role for NO? Heart 2002; 87:507-509 (Pubitemid 34547970)
27. Olson KR: The therapeutic potential of hydrogen sulfide: Separating hype from hope. Am J Physiol Regul Integr Comp Physiol 2011 May 4 [Epub ahead of print]
28. Whiteman M, Gooding KM, Whatmore JL, et al: Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia 2010; 53: 1722-1726
29. Wintner EA, Deckwerth TL, Langston W, et al: A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood. Br J Pharmacol 2010; 160:941-957