Blood leptin and C-reactive protein provide more sensitive assessment than blood lipids and other inflammatory biomarkers in overweight university students

Nutrition Research

Volumn 31, Issue 8, 2011, Pages 586-593

  Wang, Shu ^a   Reed, Debra B ^a   Goli, Srikanth ^a   Goswami, Debalina ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

Adiponectin; Body mass index; C reactive protein; Inflammation; Leptin; Obesity; Overweight; Percent body fat; University students

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; CHOLESTEROL; INTERLEUKIN 6; LEPTIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ACCURACY; ADULT; ARTICLE; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; IMPEDANCE; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY ANALYSIS; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; UNIVERSITY STUDENT;

ADIPONECTIN; ADIPOSE TISSUE; ADULT; BIOLOGICAL MARKERS; BODY COMPOSITION; BODY MASS INDEX; C-REACTIVE PROTEIN; CROSS-SECTIONAL STUDIES; FEMALE; HEALTH STATUS; HUMANS; INFLAMMATION MEDIATORS; LEPTIN; LIPIDS; MALE; OVERWEIGHT; SEX FACTORS; STUDENTS; TEXAS; UNIVERSITIES; YOUNG ADULT;

EID: 80053023147     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2011.07.006     Document Type: Article

References (54)

1. Huang T.T., Glass T.A. Transforming research strategies for understanding and preventing obesity. JAMA 2008, 300:1811-1813.
2. Singhal N., Misra A. A school-based intervention for diabetes risk reduction. N Engl J Med 2010, 363:1769-1770.
3. Rock C.L., Flatt S.W., Sherwood N.E., Karanja N., Pakiz B., Thomson C.A. Effect of a free prepared meal and incentivized weight loss program on weight loss and weight loss maintenance in obese and overweight women: a randomized controlled trial. JAMA 2010, 304:1803-1810.
4. Nomura K., Eto M., Kojima T., et al. Visceral fat accumulation and metabolic risk factor clustering in older adults. J Am Geriatr Soc 2010, 58:1658-1663.
5. American College Health Association-National College Health Assessment Spring 2008 Reference Group Data Report (abridged): the American College Health Association. J Am Coll Health 2009, 57:477-488.
6. Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 2005, 184:285-293.
7. O'Rourke R.W. Inflammation in obesity-related diseases. Surgery 2009, 145:255-259.
8. Kueht M.L., McFarlin B.K., Lee R.E. Severely obese have greater LPS-stimulated TNF-alpha production than normal weight African-American women. Obesity 2009, 17:447-451.
9. Lieb W., Pencina M.J., Lanier K.J., et al. Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study. Diabetes 2009, 58:134-137.
10. Biasucci L.M., Vitelli A., Liuzzo G., et al. Elevated levels of interleukin-6 in unstable angina. Circulation 1996, 94:874-877.
11. Forsythe L.K., Wallace J.M., Livingstone M.B. Obesity and inflammation: the effects of weight loss. Nutr Res Rev 2008, 21:117-133.
12. Rasouli N., Kern P.A. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008, 93:S64-S73.
13. Song L., Schindler C. IL-6 and the acute phase response in murine atherosclerosis. Atherosclerosis 2004, 177:43-51.
14. Rosenson R.S., Tangney C.C., Levine D.M., Parker T.S., Gordon B.R. Elevated soluble tumor necrosis factor receptor levels in non-obese adults with the atherogenic dyslipoproteinemia. Atherosclerosis 2004, 177:77-81.
15. Haddy N., Sass C., Droesch S., et al. IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort. Atherosclerosis 2003, 170:277-283.
16. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
17. Mi J., Munkonda M.N., Li M., et al. Adiponectin and leptin metabolic biomarkers in Chinese children and adolescents. J Obes 2010, 2010:892081.
18. Achike F.I., To N.H., Wang H., Kwan C.Y. Obesity, metabolic syndrome, adipocytes and vascular function: a holistic viewpoint. Clin Exp Pharmacol Physiol 2011, 1-10.
19. Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008, 29:2959-2971.
20. Qasim A., Mehta N.N., Tadesse M.G., et al. Adipokines, insulin resistance, and coronary artery calcification. J Am Coll Cardiol 2008, 52:231-236.
21. US Department of Health and Human Services, US Department of Agriculture Dietary guidelines for americans, 2005 2005, US Government Printing Office, Washington, DC. 6th ed.
22. Defining Overweight and Obesity. Internet: Centers for Disease Control and Prevention 2010. http://www.cdc.gov/obesity/defining.html.
23. American College of Sports Medicine ACSM's health-related physical fitness assessment manual 2008, Lippincott Williams & Wilkins, Philadelphia.
24. Kempf A.M., Strother M.L., Li C., Kaur H., Huang T.T. Leptin as a marker of body fat and hyperinsulinemia in college students. J Am Coll Health 2006, 55:175-180.
25. Hara T., Fujiwara H., Shoji T., Mimura T., Nakao H., Fujimoto S. Decreased plasma adiponectin levels in young obese males. J Atheroscler Thromb 2003, 10:234-238.
26. Kondo T., Kobayashi I., Murakami M. Effect of exercise on circulating adipokine levels in obese young women. Endocr J 2006, 53:189-195.
27. Mills P.J., Shapiro D., Goldstein I.B., Ottaviani C., Pung M.A., Khandrika S., et al. Metabolic predictors of inflammation, adhesion, and coagulability in healthy younger-aged adults. Obesity 2008, 16:2702-2706.
28. Galland L. Diet and inflammation. Nutr Clin Pract 2010, 25:634-640.
29. Nakajima T., Kurano M., Hasegawa T., Takano H., Iida H., Yasuda T., et al. Pentraxin3 and high-sensitive C-reactive protein are independent inflammatory markers released during high-intensity exercise. Eur J Appl Physiol 2010, 110:905-913.
30. Lakoski S.G., Cushman M., Criqui M., Rundek T., Blumenthal R.S., D'Agostino R.B., et al. Gender and C-reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort. Am Heart J 2006, 152:593-598.
31. Vikram N.K., Misra A., Dwivedi M., Sharma R., Pandey R.M., Luthra K., et al. Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescents and young adults in urban North India. Atherosclerosis 2003, 168:305-313.
32. LeCheminant J., Tucker L., Russell K. Physical activity and C-reactive protein levels: the confounding role of body fat. J Phys Act Health 2011, 8(4):481-487.
33. Klag M.J., Ford D.E., Mead L.A., et al. Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med 1993, 328:313-318.
34. Berenson G.S., Srinivasan S.R., Bao W., Newman W.P., Tracy R.E., Wattigney W.A. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998, 338:1650-1656.
35. Strong J.P., Malcom G.T., McMahan C.A., et al. Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA 1999, 281:727-735.
36. Kasapis C., Thompson P.D. The effects of physical activity on serum C-reactive protein and inflammatory markers. J Am Coll Cardiol 2005, 45:1563-1569.
37. Brennan A.M., Mantzoros C.S. Drug insight: the role of leptin in human physiology and pathophysiology-emerging clinical applications. Nat Clin Pract Endocrinol Metab 2006, 2:318-327.
38. Considine R.V., Sinha M.K., Heiman M.L., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996, 334:292-295.
39. Ukkola O., Santaniemi M. Adiponectin: a link between excess adiposity and associated comorbidities?. J Mol Med 2002, 80:696-702.
40. Lavie C.J., Milani R.V., Verma A., O'Keefe J.H. C-reactive protein and cardiovascular diseases-is it ready for primetime?. Am J Med Sci 2009, 338:486-492.
41. Cleland S.J., Sattar N., Petrie J.R., Forouhi N.G., Elliott H.L., Connell J.M. Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease. Clin Sci (Lond) 2000, 98:531-535.
42. Devaraj S., Yun J.M., Adamson G., Galvez J., Jialal I. C-reactive protein impairs the endothelial glycocalyx resulting in endothelial dysfunction. Cardiovasc Res 2009, 84:479-484.
43. Cushman M., Arnold A.M., Psaty B.M., et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation 2005, 112:25-31.
44. Lau D.C., Dhillon B., Yan H., Szmitko P.E., Verma S. Adipokines: molecular links between obesity and atherosclerosis. Am J Physiol Heart Circ Physiol 2005, 288:2031-2041.
45. Pepys M.B., Hirschfield G.M. C-reactive protein: a critical update. J Clin Invest 2003, 111:1805-1812.
46. Qasim A.N., Budharaju V., Mehta N.N., et al. Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes. Clin Endocrinol 2011, 44-50.
47. Hung M.Y., Hsu K.H., Hung M.J., Cheng C.W., Cherng W.J. Interactions among gender, age, hypertension and C-reactive protein in coronary vasospasm. Eur J Clin Invest 2010, 40:1094-1103.
48. Wang T.N., Lin M.C., Wu C.C., et al. Role of gender disparity of circulating high-sensitivity C-reactive protein concentrations and obesity on asthma in Taiwan. Clin Exp Allergy 2011, 72-77.
49. Orri J.C., Carter S.R., Howington E.B. Gender comparison of C-reactive protein and cardiovascular disease risk in college students and intercollegiate athletes. J Sports Med Phys Fitness 2010, 50:72-78.
50. Lin C.C., Kardia S.L., Li C.I., et al. The relationship of high sensitivity C-reactive protein to percent body fat mass, body mass index, waist-to-hip ratio, and waist circumference in a Taiwanese population. BMC Public Health 2010, 10:579.
51. Nayeem F., Anderson K.E., Nagamani M., Grady J.J., Lu L.J. Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women. Biomarkers 2010, 15:663-670.
52. Volgyi E., Tylavsky F.A., Lyytikainen A., Suominen H., Alen M., Cheng S. Assessing body composition with DXA and bioimpedance: effects of obesity, physical activity, and age. Obesity (Silver Spring) 2008, 16:700-705.
53. Dehghan M., Merchant A.T. Is bioelectrical impedance accurate for use in large epidemiological studies?. Nutr J 2008, 7:26. 10.1186/1475-2891-7-26.
54. D'Alonzo K.T., Aluf A., Vincent L., Cooper K. A comparison of field methods to assess body composition in a diverse group of sedentary women. Biol Res Nurs 2009, 10:274-283.