Clinical and functional prediction of moderate to severe obstructive sleep apnoea

Clinical Respiratory Journal

Volumn 5, Issue 4, 2011, Pages 219-226

  Bucca, Caterina ^a   Brussino, Luisa ^a   Maule, Milena Maria ^a   Baldi, Ileana ^a   Guida, Giuseppe ^a   Culla, Beatrice ^a   Merletti, Franco ^a   Foresi, Antonio ^b   Rolla, Giovanni ^a   Mutani, Roberto ^a   Cicolin, Alessandro ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Sesto San Giovanni Hospital   (Italy)

Author keywords

BMI; Exhaled nitric oxide; Inspiratory flow volume curve; Nomogram; Obstructive sleep apnoea

Indexed keywords

CARBOXYHEMOGLOBIN; NITRIC OXIDE;

ADULT; AIRWAY OBSTRUCTION; APNEA HYPOPNEA INDEX; ARTERIAL GAS; ARTICLE; BODY MASS; CIGARETTE SMOKING; DISEASE SEVERITY; EXHALED NITRIC OXIDE; EXPIRED AIR; FEMALE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MAXIMAL INSPIRATORY PRESSURE; MAXIMAL MID EXPIRATORY FLOW; MID INSPIRATORY AIRFLOW; NOMOGRAM; OBESITY; POLYSOMNOGRAPHY; PREDICTIVE VALIDITY; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; SPIROMETRY;

ADULT; AGED; BODY MASS INDEX; BREATH TESTS; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; NOMOGRAMS; OBESITY; POLYSOMNOGRAPHY; PULMONARY VENTILATION; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE; SPIROMETRY; YOUNG ADULT;

EID: 80053017719     PISSN: 17526981     EISSN: 1752699X     Source Type: Journal    
DOI: 10.1111/j.1752-699X.2010.00223.x     Document Type: Article

References (38)

1. American Academy of Sleep medicine Task Force. Sleep Related Breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep. 1999;22: 667-89.
2. Depalo A, Carpagnano GE, Spanevello A, Sabato R, Cagnazzo MG, Gramiccioni C, Foschino-Barbaro MP. Exhaled NO and iNOS expression in sputum cells of healthy, obese and OSA subjects. J Intern Med. 2008;263: 70-8.
3. Carpagnano GE, Spanevello A, Sabato R, Depalo A, Turchiarelli V, Foschino Barbaro MP. Exhaled pH, exhaled nitric oxide, and induced sputum cellularity in obese patients with obstructive sleep apnea syndrome. Transl Res. 2008;151: 45-50.
4. Petrosyan M, Perraki E, Simoes D, Koutsourelakis I, Vagiakis E, Roussos C, Gratziou C. Exhaled breath markers in patients with obstructive sleep apnea. Sleep Breath. 2008;12: 207-15.
5. Olopade CO, Christon JA, Zakkar M, Hua C, Swedler WI, Scheff PA, Rubinstein I. Exhaled pentane and nitric oxide levels in patients with obstructive sleep apnea. Chest. 1997;111: 1500-4.
6. Haponik EF, Bleecker ER, Allen RP, Smith PL, Kaplan J. Abnormal inspiratory flow-volume curves in patients with sleep-disordered breathing. Am Rev Respir Dis. 1981;124: 571-4.
7. Sanders MH, Stiller RA. Still going around the flow-volume loops. Chest. 1992;101: 301-2.
8. Flemons WW, Whitelaw WA, Brant R, Remmers JE. Likelihood ratios for a sleep apnea clinical prediction rule. Am J Respir Crit Care Med. 1994;150: 1279-85.
9. Herer B, Roche N, Carton M, Roig C, Poujol V, Huchon G. Value of clinical, functional, and oximetric data for the prediction of obstructive sleep apnea in obese patients. Chest. 1999;116: 1537-44.
10. Bucca C, Carossa S, Colagrande P, Brussino L, Chiavassa G, Pera P, Rolla G, Preti G. Effect of edentulism on spirometric tests. Am J Respir Crit Care Med. 2001;162: 1018-20.
11. Bucca CB, Brussino L, Battisti A, Mutani R, Rolla G, Mangiardi L, Cicolin A. Diuretics in obstructive sleep apnea with diastolic heart failure. Chest. 2007;132: 440-6.
12. Rowley JA, Aboussouan LS, Badr MS. The use of clinical prediction formulas in the evaluation of obstructive sleep apnea. Sleep. 2000;23: 929-38.
13. Kump K, Whalen C, Tishler PV, Browner I, Ferrette V, Strohl KP, Rosenberg C, Redline S. Assessment of the validity and utility of a sleep-symptom questionnaire. Am J Respir Crit Care Med. 1994;150: 735-41.
14. Iber C, Ancoli-Israel S, Chesson AL, Quan S. American Academy of Sleep Medicine: The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, 1st edn. Westchester, IL, American Academy of Sleep Medicine, 2007.
15. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen R, Peslin R, Yernault JC. Lung volume and forced ventilatory flows: report of working party, standardization of lung function tests, European Community for Steel and Coal - official statement of the European Respiratory Society. Eur Respir J. 1993;6(Suppl. 16): 5-40.
16. Pellegrino R, Viegi G, Brusasco V, etal. Interpretative strategies for lung function tests. Eur Respir J. 2005;26: 948-68.
17. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002;166: 518-624.
18. American Thoracic Society. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children - 1999. Am J Respir Crit Care Med. 1999;160: 2104-17.
19. Hastie T, Tibshirani R. Generalized Additive Models. London, Chapman & Hall, 1990.
20. Akaike H. Information theory as an extension of the maximum likelihood principle. In: Petrov BN, Csaki F, editors. Second International Symposium on Information Theory. Budapest, Akademiai Kiado, 1973: 267-81.
21. Efron B, Tibshirani R, Robert J. An Introduction to the Bootstrap. London, Chapman & Hall, 1993.
22. Hanley JA, M'Neil BJ. The meaning and the use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143: 29-36.
23. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, R Foundation for Statistical Computing, 2006 ISBN 3-900051-07-0, Available at URL.
24. Harrell FE Jr. 2005). Design: design package. R package version 2.0-12. Available at URL:.
25. Maislin G, Pack AI, Kribbs NB, Smith PL, Schwartz AR, Kline LR, Schwab RJ, Dinges DF. A survey screen for prediction of apnea. Sleep. 1995;18: 158-66.
26. Katz I, Stradling JR, Slutsky AS, Zamel N, Hoffstein V. Do patients with obstructive sleep apnea have thick necks? Am Rev Respir Dis. 1990;141: 1228-31.
27. Stauffer JL, White DP, Zwillich CW. Pulmonary function in obstructive sleep apnea. Relationships to pharyngeal resistance and cross-sectional area. Chest. 1990;97: 302-7.
28. Katz I, Zamel N, Slutsky AS, Rebuck AS, Hoffstein V. An evaluation of flow-volume curves as a screening test for obstructive sleep apnea. Chest. 1990;98: 337-40.
29. Neukirch F, Weitzenblum E, Liard R, Korobaeff M, Henry C, Orvoën-Frija E, Kauffmann F. Frequency and correlates of the saw-tooth pattern of flow-volume curves in an epidemiological survey. Chest. 1992;101: 425-31.
30. Hoffstein V, Wright S, Zamel N. Flow-volume curves in snoring patients with and without obstructive sleep apnea. Am Rev Respir Dis. 1989;139: 957-60.
31. Devouassoux G, Lévy P, Rossini E, Pin I, Fior-Gozlan M, Henry M, Seigneurin D, Pépin JL. Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness. J Allergy Clin Immunol. 2007;119: 597-603.
32. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. Elevation of plasma cytokines in disorders of excessive daytime sleepiness; role of sleep disturbance and obesity. J Clin Endocrinol Metab. 1997;82: 1313-6.
33. Foresi A, Leone C, Olivieri D, Cremona G. Alveolar-derived exhaled nitric oxide is reduced in obstructive sleep apnea syndrome. Chest. 2007;132: 860-7.
34. Ip MS, Lam B, Chan LY, Zheng L, Tsang KW, Fung PC, Lam WK. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med. 2000;162(6): 2166-71.
35. Malinovschi A, Janson C, Holmkvist T, Norbäck D, Meriläinen P, Högman M. Effect of smoking on exhaled nitric oxide and flow-independent nitric oxide exchange parameters. Eur Respir J. 2006;28: 339-45.
36. Kashyap R, Hock LM, Bowman TJ. Higher prevalence of smoking in patients diagnosed as having obstructive sleep apnea. Sleep Breath. 2001;5: 167-72.
37. Al-Shawwa BA, Badi AN, Goldberg AN, Woodson BT. Defining common outcome metrics used in obstructive sleep apnea. Sleep Med Rev. 2008;12: 449-61.
38. Chervin RD, Murman DL, Malow BA, Totten V. Cost-utility of three approaches to the diagnosis of sleep apnea: polysomnography, home testing, and empirical therapy. Ann Intern Med. 1999;130(6): 496-505.