Alveolar-derived exhaled nitric oxide is reduced in obstructive sleep apnea syndrome

Chest

Volumn 132, Issue 3, 2007, Pages 860-867

  Foresi, Antonio ^a   Leone, Clementina ^a   Olivieri, Dario ^b   Cremona, George ^c  

^a Sesto San Giovanni Hospital   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Exhaled nitric oxide; Hypertension; Nasal continuous positive airway pressure; Obstructive sleep apnea syndrome

Indexed keywords

NITRIC OXIDE;

ADULT; AGED; ARTICLE; BREATH ANALYSIS; BRONCHUS; CASE CONTROL STUDY; EXHALATION; FEMALE; HUMAN; HYPERTENSION; LUNG ALVEOLUS; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE; SLEEP APNEA SYNDROME;

ADULT; AGED; BREATH TESTS; BRONCHI; CASE-CONTROL STUDIES; CONTINUOUS POSITIVE AIRWAY PRESSURE; EXHALATION; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NITRIC OXIDE; PULMONARY ALVEOLI; SLEEP APNEA, OBSTRUCTIVE;

EID: 35448982320     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.06-3124     Document Type: Article

References (51)

1. Marin JM, Carrizo SJ, Vicente E, et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005; 365: 1046-1053 (Pubitemid 40386782)
2. Quan SF, Gersh BJ. Cardiovascular consequences of sleep-disordered breathing: past, present and future: report of a workshop from the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute. Circulation 2004; 109:951-957 (Pubitemid 38282845)
3. Lavie L, Hefetz A, Luboshitzky R, et al. Plasma levels of nitric oxide and L-arginine in sleep apnea patients: effects of nCPAP treatment. J Mol Neurosci 2003; 21:57-63 (Pubitemid 37204873)
4. Kato M, Roberts-Thomson P, Phillips BG, et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000; 102:2607-2610
5. Cremona G, Wood AM, Hall LW, et al. Effect of inhibitors of nitric oxide release and action on vascular tone in isolated lungs of pig, sheep, dog and man. J Physiol 1994; 481:185-195 (Pubitemid 24361358)
6. Peinado VI, Barbera JA, Ramirez J, et al. Endothelial dysfunction in pulmonary arteries of patients with mild COPD. Am J Physiol 1998; 274:L908-L913
7. Rubinstein I. Upper airway inflammation in obstructive sleep apnea. Am J Respir Crit Care Med 2002; 165:1023-1024 (Pubitemid 34774677)
8. Shamsuzzaman AS, Winnicki M, Lanfranchi P, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 2002; 105:2462-2464 (Pubitemid 34568964)
9. Hatipoglu U, Rubinstein I. Inflammation and obstructive sleep apnea syndrome pathogenesis: a working hypothesis. Respiration 2003; 70:665-671 (Pubitemid 38142324)
10. Arter JL, Chi DS, Girish M, et al. Obstructive sleep apnea, inflammation, and cardiopulmonary disease. Front Biosci 2004; 9:2892-2900
11. Agusti AG, Barbe F, Togores B. Exhaled nitric oxide in patients with sleep apnea. Sleep 1999; 22:231-235 (Pubitemid 29143222)
12. Olopade CO, Christon JA, Zakkar M, et al. Exhaled pentane and nitric oxide levels in patients with obstructive sleep apnea. Chest 1997; 111:1500-1504 (Pubitemid 27260072)
13. Lehtimaki L, Kankaanranta H, Saarelainen S, et al. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am J Respir Crit Care Med 2001; 163:1557-1561 (Pubitemid 32578755)
14. American Academy of Sleep Medicine. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research: the report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22:667-689
15. American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005; 171:912-930
16. George SC, Hogman M, Permutt S, et al. Modelling pulmonary nitric oxide exchange. J Appl Physiol 2004; 96:831-839 (Pubitemid 38248651)
17. Tsoukias NM, George SC. A two-compartment model of pulmonary nitric oxide exchange dynamics. J Appl Physiol 1998; 85:653-666 (Pubitemid 28365835)
18. Buchvald F, Baraldi E, Carraro S, et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 2005; 115:1130-1136 (Pubitemid 40824579)
19. Tsang KW, Ip SK, Leung R, et al. Exhaled nitric oxide: the effects of age, gender and body size. Lung 2001; 179:83-91 (Pubitemid 33022274)
20. Paraskakis E, Brindicci C, Fleming L, et al. Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma. Am J Respir Crit Care Med 2006; 174:260-267 (Pubitemid 44156604)
21. Rolla G, Brussino L, Scappaticci E, et al. Source of exhaled nitric oxide in primary biliary cirrhosis. Chest 2004; 126: 1546-1551 (Pubitemid 39525029)
22. Brindicci C, Ito K, Resta O, et al. Exhaled nitric oxide from lung periphery is increased in COPD. Eur Respir J 2005; 26:52-59 (Pubitemid 40945931)
23. Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation 2003; 107:1129-1134 (Pubitemid 36297204)
24. Imagawa S, Yamaguchi Y, Ogawa K, et al. Interleukin-6 and tumor necrosis factor-α in patients with obstructive sleep apnea-hypopnea syndrome. Respiration 2004; 71:24-29 (Pubitemid 38223762)
25. Minoguchi K, Tazaki T, Yokoe T, et al. Elevated production of tumor necrosis factor-alpha by monocytes in patients with obstructive sleep apnea syndrome. Chest 2004; 126:1473-1479 (Pubitemid 39525019)
26. Carpagnano GE, Kharitonov SA, Resta O, et al. Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest 2002; 122:1162-1167 (Pubitemid 35339525)
27. Ohga E, Nagase T, Tomita T, et al. Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome. J Appl Physiol 1999; 87:10-14 (Pubitemid 29330658)
28. Ohga E, Tomita T, Wada H, et al. Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J Appl Physiol 2003; 94:179-184 (Pubitemid 36014310)
29. Rubinstein I. Nasal inflammation in patients with obstructive sleep apnea. Laryngoscope 1995; 105:175-177
30. Sekosan M, Zakkar M, Wenig BL, et al. Inflammation in the uvula mucosa of patients with obstructive sleep apnea. Laryngoscope 1996; 106:1018-1020 (Pubitemid 26287248)
31. Goldbart AD, Goldman JL, Li RC, et al. Differential expression of cysteinyl leukotriene receptors 1 and 2 in tonsils of children with obstructive sleep apnea syndrome or recurrent infection. Chest 2004; 126:13-18 (Pubitemid 38943111)
32. Kataoka T, Enomoto F, Kim R, et al. The effect of surgical treatment of obstructive sleep apnea syndrome on the plasma TNF-α levels. Tohoku J Exp Med 2004; 204:267-272 (Pubitemid 39618670)
33. Vgontzas AN, Bixler EO, Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 2005; 9:211-224 (Pubitemid 40694188)
34. Vassilakopoulos T, Divangahi M, Rallis G, et al. Differential cytokine gene expression in the diaphragm in response to strenuous resistive breathing. Am J Respir Crit Care Med 2004; 170:154-161 (Pubitemid 38925161)
35. Salerno FG, Carpagnano E, Guido P, et al. Airway inflammation in patients affected by obstructive sleep apnea syndrome. Respir Med 2004; 98:25-28 (Pubitemid 38100751)
36. Zhan G, Fenik P, Pratico D, et al. Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolence and brain injury. Am J Respir Crit Care Med 2005; 171:1414-1420 (Pubitemid 40800515)
37. Svatikova A, Wolk R, Wang HH, et al. Circulating free nitrotyrosine in obstructive sleep apnea. Am J Physiol Regul Integr Comp Physiol 2004; 287:R284-R287 (Pubitemid 38970278)
38. Girgis RE, Gugnani MK, Abrams J, et al. Partitioning of alveolar and conducting airway nitric oxide in scleroderma lung disease. Am J Respir Crit Care Med 2002; 165:1587-1591 (Pubitemid 34693936)
39. Carlson JT, Rangemark C, Hedner JA. Attenuated endothelium- dependent vascular relaxation in patients with sleep apnoea. J Hypertens 1996; 14:577-584 (Pubitemid 26161112)
40. Haight JS, Djupesland PG. Nitric oxide (NO) and obstructive sleep apnea (OSA). Sleep Breath 2003; 7:53-62
41. Ip MS, Lam B, Chan LY, et al. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 2000; 162:2166-2171 (Pubitemid 32051681)
42. Schulz R, Schmidt D, Blum A, et al. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 2000; 55:1046-1051
43. Ip MS, Tse HF, Lam B, et al. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004; 169:348-353 (Pubitemid 38134813)
44. Zhang XL, Yin KS, Mao H, et al. Effect of continuous positive airway pressure treatment on vascular endothelial function in patients with obstructive sleep apnea hypopnea syndrome and coronary artery disease. Chin Med J (Engl) 2004; 117:844-847 (Pubitemid 38961676)
45. Teramoto S, Kume H, Matsuse T, et al. Oxygen administration improves the serum level of nitric oxide metabolites in patients with obstructive sleep apnea syndrome. Sleep Med 2003; 4:403-407 (Pubitemid 37193023)
46. Kalaria RN, Spoors L, Laude EA, et al. Hypoxia of sleep apnoea: cardiopulmonary and cerebral changes after intermittent hypoxia in rats. Respir Physiol Neurobiol 2004; 140: 53-62 (Pubitemid 38510379)
47. Altay T, Gonzales ER, Park TS, et al. Cerebrovascular inflammation after brief episodic hypoxia: modulation by neuronal and endothelial nitric oxide synthase. J Appl Physiol 2004; 96:1223-1230 (Pubitemid 38248705)
48. Sumino H, Nakamura T, Kanda T, et al. Effect of enalapril on exhaled nitric oxide in normotensive and hypertensive subjects. Hypertension 2000; 36:934-940
49. Cremona G, Higenbottam T, Takao M, et al. Exhaled nitric oxide in isolated pig lungs. J Appl Physiol 1995; 78:59-63
50. Ide H, Nakano H, Ogasa T, et al. Regulation of pulmonary circulation by alveolar oxygen tension via airway nitric oxide. J Appl Physiol 1999; 87:1629-1636
51. Duplain H, Sartori C, Lepori M, et al. Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation. Am J Respir Crit Care Med 2000; 162:221-224 (Pubitemid 30469824)