The assembly of proline-rich membrane anchor (PRiMA)-linked acetylcholinesterase enzyme: Glycosylation is required for enzymatic activity but not for oligomerization

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 32948-32961

  Chen, Vicky P ^a   Choi, Roy C Y ^a   Chan, Wallace K B ^a   Leung, K Wing ^a   Guo, Ava J Y ^a   Chan, Gallant K L ^a   Luk, Wilson K W ^a   Tsim, Karl W K ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CATALYTIC SUBUNITS; ENDOPLASMIC RETICULUM; ENZYMATIC ACTIVITIES; GOLGI APPARATUS; MEMBRANE ANCHORS; N-GLYCOSYLATION SITES; N-LINKED GLYCOSYLATION; TETRAMERS; TRANS-MEMBRANE PROTEINS; VERTEBRATE BRAINS; WILD TYPES;

AMINO ACIDS; BRAIN; CELL MEMBRANES; CYTOLOGY; DATA PRIVACY; ENZYMES; ESTERIFICATION; GLYCOSYLATION; OLIGOMERIZATION; OLIGOMERS;

NETWORK SECURITY;

ACETYLCHOLINESTERASE; GLYCAN; MEMBRANE PROTEIN; PROLINE RICH MEMBRANE ANCHOR; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; WILD TYPE;

ACETYLCHOLINESTERASE; ANIMALS; BIOCATALYSIS; CHICKENS; ENZYME STABILITY; GLYCOSYLATION; GPI-LINKED PROTEINS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS;

VERTEBRATA;

EID: 80053016842     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.261248     Document Type: Article

References (41)

1. Massoulié, J., Pezzementi, L., Bon, S., Krejci, E., and Vallette, F. M. (1993) Prog. Neurobiol. 41, 31-91
2. Krejci, E., Thomine, S., Boschetti, N., Legay, C., Sketelj, J., and Massoulié, J. (1997) J. Biol. Chem. 272, 22840-22847
3. Massoulié, J., and Millard, C. B. (2009) Curr. Opin. Pharmacol. 9, 316-325
4. Perrier, A. L., Massoulié, J., and Krejci, E. (2002) Neuron 33, 275-285
5. Mok, M. K., Leung, K. W., Xie, H. Q., Guo, A. J., Chen, V. P., Zhu, J. T., Choi, R. C., and Tsim, K. W. (2009) Neurosci. Lett. 461, 202-206
6. Xie, H. Q., Liang, D., Leung, K. W., Chen, V. P., Zhu, K. Y., Chan, W. K., Choi, R. C., Massoulié, J., and Tsim, K. W. (2010) J. Biol. Chem. 285, 11537-11546
7. Xie, H. Q., Choi, R. C., Leung, K. W., Siow, N. L., Kong, L. W., Lau, F. T., Peng, H. B., and Tsim, K. W. (2007) J. Biol. Chem. 282, 11765-11775
8. Bon, S., Coussen, F., and Massoulié, J. (1997) J. Biol. Chem. 272, 3016-3021
9. Dvir, H., Harel, M., Bon, S., Liu, W. Q., Vidal, M., Garbay, C., Sussman, J. L., Massoulié, J., and Silman, I. (2004) EMBO J. 23, 4394-4405
10. Liao, J., Heider, H., Sun, M. C., and Brodbeck, U. (1992) J. Neurochem. 58, 1230-1238
11. Liao, J., Heider, H., Sun, M. C., Stieger, S., and Brodbeck, U. (1991) Eur. J. Biochem. 198, 59-65
12. Tsim, K. W., Randall, W. R., and Barnard, E. A. (1988) J. Neurochem. 51, 95-104
13. Méflah, K., Bernard, S., and Massoulié, J. (1984) Biochimie 66, 59-69
14. Helenius, A. (1994) Mol. Biol. Cell 5, 253-265
15. Velan, B., Kronman, C., Ordentlich, A., Flashner, Y., Leitner, M., Cohen, S., and Shafferman, A. (1993) Biochem. J. 296, 649-656
16. Rotundo, R. L. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 479-483
17. Sáez-Valero, J., Barquero, M. S., Marcos, A., McLean, C. A., and Small, D. H. (2000) J. Neurol. Neurosurg. Psychiatry 69, 664-667
18. Mimori, Y., Nakamura, S., and Yukawa, M. (1997) Behav. Brain Res. 83, 25-30
19. Noureddine, H., Carvalho, S., Schmitt, C., Massoulié, J., and Bon, S. (2008) J. Biol. Chem. 283, 20722-20732
20. Gough, N. R., and Randall, W. R. (1995) J. Neurochem. 65, 2734-2741
21. Chen, V. P., Xie, H. Q., Chan, W. K., Leung, K. W., Chan, G. K., Choi, R. C., Bon, S., Massoulié, J., and Tsim, K. W. (2010) J. Biol. Chem. 285, 27265-27278
22. Choi, R. C., Leung, P. W., Dong, T. T., Wan, D. C., and Tsim, K. W. (1996) Neurosci. Lett. 217, 165-168
23. Ellman, G. L., Courtney, K. D., Andres, V., Jr., and Feather-Stone, R. M. (1961) Biochem. Pharmacol. 7, 88-95
24. Santos, S. C., Vala, I., Miguel, C., Barata, J. T., Garção, P., Agostinho, P., Mendes, M., Coelho, A. V., Calado, A., Oliveira, C. R., e Silva, J. M., and Saldanha, C. (2007) J. Biol. Chem. 282, 25597-25603
25. Tung, E. K., Choi, R. C., Siow, N. L., Jiang, J. X., Ling, K. K., Simon, J., Barnard, E. A., and Tsim, K. W. (2004) Mol. Pharmacol. 66, 794-806
26. Holden, P., and Horton, W. A. (2009) BMC Res. Notes 2, 243
27. Marra, P., Maffucci, T., Daniele, T., Tullio, G. D., Ikehara, Y., Chan, E. K., Luini, A., Beznoussenko, G., Mironov, A., and De Matteis, M. A. (2001) Nat. Cell Biol. 3, 1101-1113
28. Meyer-Schaller, N., Chou, Y. C., Sumara, I., Martin, D. D., Kurz, T., Katheder, N., Hofmann, K., Berthiaume, L. G., Sicheri, F., and Peter, M. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 12365-12370
29. Dobbertin, A., Hrabovska, A., Dembele, K., Camp, S., Taylor, P., Krejci, E., and Bernard, V. (2009) J. Neurosci. 29, 4519-4530
30. Sussman, J. L., Harel, M., Frolow, F., Oefner, C., Goldman, A., Toker, L., and Silman, I. (1991) Science 253, 872-879
31. Morel, N., Leroy, J., Ayon, A., Massoulié, J., and Bon, S. (2001) J. Biol. Chem. 276, 37379-37389
32. Liang, D., Blouet, J. P., Borrega, F., Bon, S., and Massoulié, J. (2009) FEBS J. 276, 94-108
33. Noureddine, H., Schmitt, C., Liu, W., Garbay, C., Massoulié, J., and Bon, S. (2007) J. Biol. Chem. 282, 3487-3497
34. Palade, G. (1975) Science 189, 347-358
35. Luzikov, V. N. (2002) Biochemistry 67, 171-183
36. Rotundo, R. L. (1988) J. Biol. Chem. 263, 19398-19406
37. Rotundo, R. L., Thomas, K., Porter-Jordan, K., Benson, R. J., Fernandez- Valle, C., and Fine, R. E. (1989) J. Biol. Chem. 264, 3146-3152
38. Ruiz, C. A., and Rotundo, R. L. (2009) J. Biol. Chem. 284, 21488-21495
39. Chatel, J. M., Grassi, J., Frobert, Y., Massoulié, J., and Vallette, F. M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 2476-2480
40. Choi, R. C., Yung, L. Y., Dong, T. T., Wan, D. C., Wong, Y. H., and Tsim, K. W. (1998) J. Neurochem. 71, 152-160
41. Choi, R. C., Siow, N. L., Zhu, S. Q., Wan, D. C., Wong, Y. H., and Tsim, K. W. (2001) Mol. Cell. Neurosci. 17, 732-745