Abnormalities of acetylcholinesterase in Alzheimer's disease with special reference to effect of acetylcholinesterase inhibitor

Behavioural Brain Research

Volumn 83, Issue 1-2, 1997, Pages 25-30

  Mimori, Yasuyo ^a   Nakamura, Shigenobu ^a   Yukawa, Motoko ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

acetylcholinesterase; acetylcholinesterase inhibitor; Alzheimer's disease; isozyme; senile plaque

Indexed keywords

ACETYLCHOLINESTERASE; AMIRIDINE; CHOLINESTERASE INHIBITOR; DONEPEZIL; NICERGOLINE; PHYSOSTIGMINE; RIVASTIGMINE; TACRINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENILE PLAQUE;

EID: 0031081161     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)86041-X     Document Type: Conference Paper

References (13)

1. [1] Candy, J.M., Klinowski, J., Perry, R.H., Fairbairn, A., Oakley, A.E., Carpenter, T.A., Atack, J.R., Blessed, G. and Edwardson, J.A., Aluminosilicates and senile plaque formation in Alzheimer's disease, Lancet, 1 (1986) 354-357.
2. [2] Kalaria, R.U., Kroon, S.N., Gracovac, I. and Perry, G., Acetylcholinesterase and its association with heparan sulfate proteoglycans in cortical amyloid deposits of Alzheimer's disease, Neuroscience, 51 (1992) 177-184.
3. [3] Lowry, O.H., Rosenbrough, N.J., Farr, A.L. and Randall, R.J., Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
4. [4] Martin, R.G. and Ames, B.N., A method for determining the sedimentation behavior of enzymes - application to protein mixtures, J. Biol. Chem., 236 (1961) 1372-1379.
5. [5] Massoulie, J. and Bon, S., The molecular forms of cholinesterase and acetylcholinesterase in vertebrates, Annu. Rev. Neurosci., 5 (1982) 57-106.
6. [6] Mesulam, M.M. and Moran, M.A., Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease, Ann. Neurol, 22 (1987) 223-228.
7. [7] Mesulam, M.M., Guela, C. and Moran, M.A., Anatomy of cholinesterase inhibition in Alzheimer's disease; effect of physostigmine and tetrahydroaminoacridine on plaques and tangles, Ann. Neurol, 22 (1987) 683-691.
8. [8] Nakamura, S., Kawashima, S., Nakano, S., Tsuji, T. and Araki, W., Subcellular distribution of acetylcholinesterase in Alzheimer's disease; abnormal localization and solubilization, J. Neural Transm., Suppl., 30 (1990) 13-23.
9. [9] Nakamura, S., Koshimura, K., Tanaka, S., Mimori, Y. and Kitaguchi, N., Qualitative changes of neurotransmitters in Alzheimer's disease. In: T. Ishii, D. Allsop and D.J. Selkoe (Eds.), Frontiers of Alzheimer Research, Elsevier, Amsterdam, 1991, pp. 275-286.
10. [10] Nakano, S., Kato, T., Nakamura, S. and Kameyama, M., Acetylcholinesterase activity in cerebrospinal fluid of patients with Alzheimer's disease and senile dementia, J. Neurol. Sci., 75 (1986) 213-223.
11. [11] Navaratnam, D.S., Priddle, J.D., McDonald, B., Esiri, M.M., Robinson, J.R. and Smith, A.D., Anomalous molecular form of acetylcholinesterase in cerebrospinal fluid in histochemically diagnosed Alzheimer's disease, Lancet, 337 (1991) 447-450.
12. [12] Younkin, S.G., Rosenstein, C., Collins, P.L. and Rosenberry, T.L., Cellular localization of the molecular forms of acetylcholinesterase in rat diaphragm, J. Biol. Chem., 257 (1982) 13630-13637.
13. [13] Younkin, S.G., Goodridge, B., Katz, J., Lockett, G., Nafziger, D., Usik, M.F. and Younkin, L.H., Molecular forms of acetylcholinesterase in Alzheimer's disease, Fed. Proc., 45 (1986) 2982-2988.