Process research on the asymmetric hydrogenation of a benzophenone for developing the manufacturing process of the squalene synthase inhibitor TAK-475

Organic Process Research and Development

Volumn 15, Issue 5, 2011, Pages 1178-1184

  Goto, Mitsutaka ^a   Konishi, Takahiro ^a   Kawaguchi, Shinji ^a   Yamada, Masatoshi ^a   Nagata, Toshiaki ^a   Yamano, Mitsuhisa ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC HYDROGENATION; DIPHOSPHINES; LOW HYDROGEN PRESSURE; MANUFACTURING PROCESS; NOVEL LIGANDS; OPERATING PRESSURE; PRECATALYSTS; SYNTHASE INHIBITOR; SYNTHETIC METHODS;

HYDROGEN; INDUSTRIAL RESEARCH; RUTHENIUM; RUTHENIUM COMPOUNDS;

HYDROGENATION;

EID: 80053004861     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op2001673     Document Type: Article

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