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Volumn 10, Issue 2, 2002, Pages 385-400

Syntheses of fused heterocyclic compounds and their inhibitory activities for squalene synthase

(8) Miki, Takashi a Kori, Masakuni a Fujishima, Akira a Mabuchi, Hiroshi a Tozawa, Ryu ichi a Nakamura, Masahira a Sugiyama, Yasuo a Yukimasa, Hidefumi a

a TAKEDA PHARMACEUTICAL COMPANY LIMITED (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTHIAZEPINE DERIVATIVE; CHOLESTEROL; FUSED HETEROCYCLIC RINGS; SQUALENE SYNTHASE;

ALKYLATION; AQUEOUS SOLUTION; ARTICLE; ATHEROSCLEROSIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DETERMINATION; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; ISOMER; NONHUMAN; OXIDATION; PRESSURE; STRUCTURE ACTIVITY RELATION; TEMPERATURE;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER; MALE; MOLECULAR STRUCTURE; OXAZEPINES; RATS; RATS, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036132250 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(01)00289-9 Document Type: Article

Times cited : (59)

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