Comparison of antioxidative and antifibrotic effects of α-tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis

Pancreas

Volumn 40, Issue 7, 2011, Pages 1091-1096

  Jiang, Fei ^a   Liao, Zhuan ^a   Hu, Liang Hao ^a   Du, Yi Qi ^a   Man, Xiao Hua ^a   Gu, Jun Jun ^a   Gao, Jun ^a   Gong, Yan Fang ^a   Li, Zhao Shen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

tocopherol; antifibrosis; antioxidation; chronic pancreatitis; pancreatic fibrosis; tocotrienol rich fraction

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; COLLAGEN; DIBUTYLTIN DICHLORIDE; HYDROXYPROLINE; MALONALDEHYDE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CHRONIC PANCREATITIS; CYSTIC FIBROSIS; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; GENE EXPRESSION; HISTOLOGY; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREAS INJURY; PANCREATIC STELLATE CELL; PRIORITY JOURNAL; RAT;

ACTINS; ADMINISTRATION, ORAL; ALPHA-TOCOPHEROL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; FIBROSIS; GENE EXPRESSION REGULATION; HYDROXYPROLINE; MALE; MALONDIALDEHYDE; ORGANOTIN COMPOUNDS; OXIDATIVE STRESS; PANCREAS; PANCREATITIS, CHRONIC; RATS; RATS, WISTAR; RNA, MESSENGER; TIME FACTORS; TOCOTRIENOLS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 80052998719     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31821b59c6     Document Type: Article

References (24)

1. Etemad B, Whitcomb DC. Chronic pancreatitis: Diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120:682-707. (Pubitemid 32171640)
2. Witt H, Apte MV, Keim V, et al. Chronic pancreatitis: Challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology. 2007;132:1557-1573. (Pubitemid 46627604)
3. Jaster R. Molecular regulation of pancreatic stellate cell function. Mol Cancer. 2004;3:26.
4. Lemke M, Gorl N, Berg A, et al. Influence of selenium treatment on the acute toxicity of dibutylin dichloride in rats. Pancreatology. 2006;6:486-496. (Pubitemid 44624283)
5. Ohashi S, Nishio A, Nakamura H, et al. Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice. Antioxid Redox Signal. 2006;8:1835-1845. (Pubitemid 44726356)
6. Tasci I, Deveci S, Isik AT, et al. Allopurinol in rat chronic pancreatitis: Effects on pancreatic stellate cell activation. Pancreas. 2007;35:366-371. (Pubitemid 350307382)
7. Yan MX, Li YQ, Meng M, et al. Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia. Biochem Biophys Res Commun. 2006;347:192-199. (Pubitemid 44026487)
8. Zeki S, Miura S, Suzuki H, et al. Xanthine oxidaseYderived oxygen radicals play significant roles in the development of chronic pancreatitis in wbn/kob rats. J Gastroenterol Hepatol. 2002;17:606-616. (Pubitemid 34748184)
9. Kirk GR, White JS, McKie L, et al. Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. J Gastrointest Surg. 2006;10:499-503. (Pubitemid 43696992)
10. Bhardwaj P, Garg PK, Maulik SK, et al. A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. Gastroenterology. 2009;136:149-159.
11. Yoo BM, Oh TY, Kim YB, et al. Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model. Pancreatology. 2005;5:165-176.
12. Satoh K, Shimosegawa T, Hirota M, et al. Expression of transforming growth factor beta1 (tgfbeta1) and its receptors in pancreatic duct cell carcinoma and in chronic pancreatitis. Pancreas. 1998;16:468-474. (Pubitemid 28217532)
13. Sparmann G, Merkord J, Jaschke A, et al. Pancreatic fibrosis in experimental pancreatitis induced by dibutylin dichloride. Gastroenterology. 1997;112:1664-1672. (Pubitemid 27181392)
14. Chow CK, Ibrahim W, Wei Z, et al. Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Radic Biol Med. 1999;27:580-587. (Pubitemid 29408644)
15. Sen CK, Khanna S, Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci. 2006;78:2088-2098.
16. Khosla P, Patel V, Whinter JM, et al. Postprandial levels of the natural vitamin E tocotrienol in human circulation. Antioxid Redox Signal. 2006;8:1059-1068. (Pubitemid 44036522)
17. Apte MV, Phillips PA, Fahmy RG, et al. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology. 2000;118:780-794. (Pubitemid 30171628)
18. Gomez JA, Molero X, Vaquero E, et al. Vitamin E attenuates biochemical and morphological features associated with development of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2004;287:G162-G169. (Pubitemid 38802130)
19. van Westerloo DJ, Florquin S, de Boer AM, et al. Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice. Am J Pathol. 2005;166:721-728. (Pubitemid 40315629)
20. Ilker T, Salih D, Ahmet TI, et al. Allopurinol in rat chronic pancreatitis: Effects on pancreatic stellate cell activation. Pancreas. 2007;35:366-371.
21. Lu XL, Dong XY, Fu YB, et al. Protective effect of salvianolic acid B on chronic pancreatitis induced by trinitrobenzene sulfonic acid solution in rats. Pancreas. 2009;38:71-77.
22. Ohashi S, Nishio A, Nakamura H, et al. Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2006;290:G772-G781.
23. Merkord J, Jonas L, Weber H, et al. Acute interstitial pancreatitis in rats induced by dibutylin dichloride (DBTC): Pathogenesis and natural course of lesions. Pancreas. 1997;15:392-401. (Pubitemid 27525636)
24. Rickmann M, Vaquero EC, Malagelada JR, et al. Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology. 2007;132:2518-2532. (Pubitemid 46890868)