Rapid immune recovery and low TRM in haploidentical stem cell transplantation in children and adolescence using CD3/CD19-depleted stem cells

Best Practice and Research: Clinical Haematology

Volumn 24, Issue 3, 2011, Pages 331-337

  Bader, Peter ^a   Soerensen, Jan ^a   Jarisch, Andrea ^a   Ponstingl, Eva ^a   Krenn, Thomas ^c   Faber, Jörg ^d   Dürken, Matthias ^e   Reinhardt, Harald ^f   Willasch, Andre ^a   Esser, Ruth ^a   Bönig, Halvard ^b   Koehl, Ulrike ^a   Klingebiel, Thomas ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Institute for Transfusion Medicine and Immunohaematology   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f Asklepios Clinic   (Germany)

Author keywords

haploidentical stem cell transplantation; immunotherapy; leukemia; malignant and non malignant diseases

Indexed keywords

CD19 ANTIGEN; CD3 ANTIGEN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MEGAKARYOCYTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; GRAFT VERSUS HOST REACTION; HAPLOIDENTICAL STEM CELL TRANSPLANTATION; HUMAN; MESENCHYMAL STEM CELL; MORTALITY; MYELOID LEUKEMIA; NATURAL KILLER CELL; PRIORITY JOURNAL; RECURRENCE RISK; RHABDOMYOSARCOMA; STEM CELL TRANSPLANTATION; T CELL DEPLETION; T LYMPHOCYTE; THROMBOCYTE; TRANSPLANT RELATED MORTALITY;

EID: 80052979902     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2011.04.005     Document Type: Review

References (24)

1. P.G. Beatty, M. Mori, and E. Milford Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor Transplantation 60 8 1995 Oct 27 778 783
2. J.A. Hansen, E. Petersdorf, and P.J. Martin Hematopoietic stem cell transplants from unrelated donors Immunol Rev 157 1997 Jun 141 151 (Pubitemid 27303126)
3. G.K. Rivera, D. Pinkel, and J.V. Simone Treatment of acute lymphoblastic leukemia. 30 year's experience at St. Jude Children's Research Hospital N Engl J Med 329 18 1993 Oct 28 1289 1295 (Pubitemid 23317327)
4. A. Willasch, W. Hoelle, and H. Kreyenberg Outcome of allogeneic stem cell transplantation in children with non-malignant diseases Haematologica 91 6 2006 Jun 788 794 (Pubitemid 44014545)
5. F. Aversa, A. Tabilio, and A. Terenzi Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum Blood 84 11 1994 Dec 1 3948 3955
6. + stem cells: a new option for leukemia patients without an HLA-matched donor Curr Opin Immunol 12 5 2000 Oct 536 541
7. + cell transplants Exp Hematol 28 2 2000 Feb 119 127 (Pubitemid 30100818)
8. J.M. Rowe, and H.M. Lazarus Genetically haploidentical stem cell transplantation for acute leukemia Bone Marrow Transplant 27 7 2001 Apr 669 676 (Pubitemid 32409439)
9. F. Aversa, A. Tabilio, and A. Velardi Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype N Engl J Med 339 17 1998 Oct 22 1186 1193 (Pubitemid 28482127)
10. T. Klingebiel, R. Handgretinger, and P. Lang Haploidentical transplantation for acute lymphoblastic leukemia in childhood Blood Rev 18 3 2004 Sep 181 192 (Pubitemid 38859628)
11. R. Handgretinger, T. Klingebiel, and P. Lang Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children Bone Marrow Transplant 27 8 2001 Apr 777 783 (Pubitemid 32496409)
12. T. Klingebiel, J. Cornish, and M. Labopin Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplant in children with very-high risk acute lymphoblastic leukemia - impact of center size: an analysis on behalf of the acute leukemia and pediatric disease working parties of the European blood and marrow transplant group Blood 2009 Dec 29
13. P. Bader, A. Willasch, and D. Niethammer Haploidentical stem cell transplantation in childhood Curr Canc Ther Rev 3 2007 37 44 (Pubitemid 46510732)
14. H.J. Kolb, A. Schattenberg, and J.M. Goldman Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European group for blood and marrow transplantation working party chronic leukemia Blood 86 5 1995 Sep 1 2041 2050
15. T.B. Prigozhina, O. Gurevitch, and J. Zhu Permanent and specific transplantation tolerance induced by a nonmyeloablative treatment to a wide variety of allogeneic tissues: I. Induction of tolerance by a short course of total lymphoid irradiation and selective elimination of the donor-specific host lymphocytes Transplantation 63 10 1997 May 27 1394 1399 (Pubitemid 27237440)
16. S. Slavin, A. Nagler, and E. Naparstek Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases Blood 91 3 1998 Feb 1 756 763 (Pubitemid 28078275)
17. R. Storb, C. Yu, and B.M. Sandmaier Mixed hematopoietic chimerism after marrow allografts. Transplantation in the ambulatory care setting Ann N Y Acad Sci 872 1999 Apr 30 372 375
18. R. Storb, C. Yu, and J.M. Zaucha Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant Blood 94 7 1999 Oct 1 2523 2529 (Pubitemid 29467702)
19. L. Ruggeri, M. Capanni, and E. Urbani Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants Science 295 5562 2002 Mar 15 2097 2100 (Pubitemid 34229476)
20. E.J. Lowe, V. Turner, and R. Handgretinger T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation Br J Haematol 123 2 2003 Oct 323 326 (Pubitemid 37305068)
21. P. Lang, and R. Handgretinger Haploidentical SCT in children: an update and future perspectives Bone Marrow Transplant 42 Suppl. 2 2008 Oct S54 S59
22. J. Toporski, M. Garkavij, and J. Tennvall High-dose iodine-131- metaiodobenzylguanidine with haploidentical stem cell transplantation and posttransplant immunotherapy in children with relapsed/refractory neuroblastoma Biol Blood Marrow Transplant 15 9 2009 Sep 1077 1085
23. P. Lang, M. Schumm, and J. Greil A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study Klin Padiatr 217 6 2005 Nov 334 338 (Pubitemid 41746115)
24. + progenitor cells from related and unrelated donors in children with nonmalignant diseases Bone Marrow Transplant 33 1 2004 Jan 25 32 (Pubitemid 38159700)