Sex hormones, insulin resistance, and diabetes mellitus among men with or at risk for HIV infection

Journal of Acquired Immune Deficiency Syndromes

Volumn 58, Issue 2, 2011, Pages 173-180

  Monroe, Anne K ^a   Dobs, Adrian S ^a   Xu, Xiaoqiang ^a   Palella, Frank J ^b   Kingsley, Lawrence A ^c   Witt, Mallory D ^d   Brown, Todd T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

diabetes mellitus; HIV; insulin resistance; sex hormone binding globulin; testosterone

Indexed keywords

ABACAVIR; ATAZANAVIR; DARUNAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; FOSAMPRENAVIR; INDINAVIR; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; SEX HORMONE BINDING GLOBULIN; STAVUDINE; TENOFOVIR; TESTOSTERONE; TIPRANAVIR; ZIDOVUDINE;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MEGADOSE; DRUG USE; ETHNICITY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MALE HOMOSEXUAL; MULTICENTER STUDY; PREVALENCE; PRIORITY JOURNAL; SELF REPORT;

ADULT; BLOOD GLUCOSE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS; FASTING; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HUMANS; INSULIN RESISTANCE; LOGISTIC MODELS; LOPINAVIR; MALE; MIDDLE AGED; ODDS RATIO; REVERSE TRANSCRIPTASE INHIBITORS; RITONAVIR; SEX HORMONE-BINDING GLOBULIN; STAVUDINE; TESTOSTERONE;

EID: 80052962820     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3182278c09     Document Type: Article

References (48)

1. Howard AA, Floris-Moore M, Lo Y, et al. Abnormal glucose metabolism among older men with or at risk of HIV infection. HIV Med. 2006;7:389-396. (Pubitemid 44123250)
2. Brown TT, Cole SR, Li X, et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med. 2005;165:1179-1184. (Pubitemid 40720744)
3. Tien PC, Schneider MF, Cole SR, et al. Antiretroviral therapy exposure and incidence of diabetes mellitus in theWomen's Interagency HIV Study. AIDS. 2007;21:1739-1745. (Pubitemid 47237561)
4. Colangelo LA, Ouyang P, Liu K, et al. Association of endogenous sex hormones with diabetes and impaired fasting glucose in men. Diabetes Care. 2009;32:1049-1051.
5. Selvin E, Feinleib M, Zhang L, et al. Androgens and diabetes in men: results from the third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007;30:234-238. (Pubitemid 46198324)
6. Klein RS, Lo Y, Santoro N, et al. Androgen levels in older men who have or who are at risk of acquiring HIV infection. Clin Infect Dis. 2005;41: 1794-1803. (Pubitemid 41759867)
7. Dobs AS, Few 3rd WL, Blackman MR, et al. Serum hormones in men with human immunodeficiency virus-associated wasting. J Clin Endocrinol Metab. 1996;81:4108-4112. (Pubitemid 26380425)
8. Wunder DM, Bersinger NA, Fux CA, et al. Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy. Antivir Ther. 2007;12:261-265. (Pubitemid 46569911)
9. Ding EL, Song Y, Malik VS, et al. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and metaanalysis. JAMA. 2006;295:1288-1299.
10. Grossmann M, Thomas M, Panagiotopoulos S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab. 2008;93:1834-1840. (Pubitemid 351656526)
11. Martin ME, Benassayag C, Amiel C, et al. Alterations in the concentrations and binding properties of sex steroid binding protein and corticosteroid-binding globulin in HIV+patients. J Endocrinol Invest. 1992;15:597-603.
12. Kaslow RA, Ostrow DG, Detels R, et al. The Multicenter AIDS Cohort Study: rationale, organization, and selected characteristics of the participants. Am J Epidemiol. 1987;126:310-318. (Pubitemid 17102758)
13. Kingsley L, Cuervo-Rojas J, Muñoz A, et al. Subclinical coronary atherosclerosis, HIV infection and antiretroviral therapy: multicenter AIDS Cohort Study. AIDS. 2008;22:1589-1599.
14. Matthews D, Hosker J, Rudenski A, et al. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419. (Pubitemid 15018832)
15. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84:3666-3672. (Pubitemid 30645223)
16. Butt AA, McGinnis K, Rodriguez-Barradas MC, et al. HIV infection and the risk of diabetes mellitus. AIDS. 2009;23:1227-1234.
17. Ledergerber B, Furrer H, Rickenbach M, et al. Factors associated with the incidence of type 2 diabetes mellitus in HIV infected participants in the Swiss HIV Cohort Study. Clin Infect Dis. 2007;45:111-119. (Pubitemid 46984626)
18. DeWit S, Sabin CA,Weber R, et al. Incidence and risk factors for new-onset diabetes in HIV-infected patients. Diabetes Care. 2008;31:1224-1229.
19. Brown TT, Li X, Cole SR, et al. Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study. AIDS. 2005; 19:1375-1383. (Pubitemid 41800673)
20. Laaksonen D, Niskanen L, Punnonen K, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004;27:1036-1041. (Pubitemid 38579762)
21. Fleischman A, Johnsen S, Systrom D, et al. Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults. Am J Physiol Endocrinol Metab. 2007;292:E1666-E1673. (Pubitemid 47084702)
22. Mehta SH, Moore RD, Thomas DL, et al. The effect of HAART and HCV infection on the development of hyperglycemia among HIV-infected persons. J Acquir Immune Defic Syndr. 2003;33:577-584. (Pubitemid 36975845)
23. Paul Chubb S, Hyde Z, Almeida O, et al. Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study. Eur J Endocrinol. 2008;158:785-792. (Pubitemid 351837366)
24. Menke A, Guallar E, Rohrmann S, et al. Sex steroid hormone concentrations and risk of death in US men. Am J Epidemiol. 2010; 171:583-592.
25. Laughlin GA, Barrett-Connor E, Bergstrom J. Low serum testosterone and mortality in older men. J Clin Endocrinol Metab. 2008;93:68-75.
26. Kalyani RR, Dobs AS. Androgen deficiency, diabetes, and the metabolic syndrome in men. Curr Opin Endocrinol Diabetes Obes. 2007;14:226-234. (Pubitemid 46684478)
27. Haffner SM, Shaten J, Stem MP, et al. Low levels of sex hormonebinding globulin and testosterone predict the development of noninsulin-dependent diabetes mellitus in men. Am J Epidemiol. 1996;143: 889-897. (Pubitemid 26131096)
28. Stellato RK, Feldman HA, Hamdy O, et al. Testosterone, sex hormonebinding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care. 2000;23:490-494. (Pubitemid 30185792)
29. Oh JY, Barrett-Connor E, Wedick NM, et al. Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study. Diabetes Care. 2002;25:55-60. (Pubitemid 41070783)
30. Grossmann M, Gianatti E, Zajac J. Testosterone and type 2 diabetes. Curr Opin Endocrinol Diabetes Obes. 2010;17:247-256.
31. Rietschel P, Corcoran C, Stanley T, et al. Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy. Clin Infect Dis. 2000;31:1240-1244. (Pubitemid 32295456)
32. Grinspoon S. Androgen deficiency and HIV infection. Clin Infect Dis. 2005;41:1804-1805.
33. Plymate S, Tenover J, Bremner W. Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormonebinding globulin bound testosterone in healthy young and elderly men. J Androl. 1989;10:366-371. (Pubitemid 19266891)
34. Brambilla DJ, Matsumoto AM, Araujo AB, et al. The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men. J Clin Endocrinol Metab. 2009;94:907-913.
35. Miller J, Carr A, Emery S, et al. HIV lipodystrophy: prevalence, severity and correlates of risk in Australia. HIV Med. 2003;4:293-301. (Pubitemid 36949887)
36. Ding EL, Song Y, Manson JE, et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med. 2009;361:1152-1163.
37. Lakshman K, Bhasin S, Araujo A. Sex hormone-binding globulin as an independent predictor of incident type 2 diabetes mellitus in men. J Gerontol A Biol Sci Med Sci. 2010;65:503-509.
38. Hammes A, Andreassen T, Spoelgen R, et al. Role of endocytosis in cellular uptake of sex steroids. Cell. 2005;122:751-762. (Pubitemid 41242639)
39. Peter A, Kantartzis K, Machann J, et al. Relationships of circulating sex hormone-binding globulin with metabolic traits in humans. Diabetes. 2010;59:3167-3173.
40. Ristig M, Drechsler H, Powderly WG. Review: hepatic steatosis and HIV infection. AIDS Patient Care STDS. 2005;19:356-365. (Pubitemid 40962010)
41. Diver MJ, ImtiazKE, AhmadAM, et al. Diurnal rhythms of serumtotal, free and bioavailable testosterone and of SHBG in middle aged men compared with those in young men. Clin Endocrinol (Oxf). 2003;58:710-717. (Pubitemid 36702730)
42. Hadigan C, Meigs J, Corcoran C, et al. Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy. Clin Infect Dis. 2001;32:130-139. (Pubitemid 32150958)
43. Kapoor D, Goodwin E, Channer KS, et al. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol. 2006;154:899-906. (Pubitemid 43997730)
44. Simon D, Charles M, Lahlou N, et al. Androgen therapy improves insulin sensitivity and decreases leptin level in healthy adult men with low plasma total testosterone. Diabetes Care. 2001;24:2149-2151.
45. Basu R, Man C, Campioni M, et al. Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men. Diabetes Care. 2007;30:1972-1978. (Pubitemid 47219403)
46. Corrales J, Burgo R, García-Berrocal B, et al. Partial androgen deficiency in aging type 2 diabetic men and its relationship to glycemic control. Metabolism. 2004;53:666-672. (Pubitemid 38596543)
47. Bhasin S, Parker RA, Sattler F, et al. Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity. J Clin Endocrinol Metab. 2007;92:1049-1057. (Pubitemid 46465682)
48. Hadigan C, Corcoran C, Basgoz N, et al. Metformin in the treatment of HIV lipodystrophy syndrome. JAMA. 2000;284:472-477.