A novel cell culture model for studying ischemia-reperfusion injury in lung transplantation

Journal of Applied Physiology

Volumn 89, Issue 4, 2000, Pages 1553-1560

  Cardella, Jonathan A ^b   Keshavjee, Shaf ^b   Mourgeon, Eric ^b   Cassivi, Stephen D ^b   Fischer, Stefan ^b   Isowa, Noritaka ^b   Slutsky, Arthur ^a,b   Liu, Mingyao ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Acute lung injury; Cell viability; Epithelial cells; Organ preservation

Indexed keywords

BOVINE SERUM ALBUMIN; CALCIUM; DEXTRAN; GLUCOSE; POTASSIUM; PRESERVATION SOLUTION;

ARTICLE; BIOLOGICAL MODEL; CELL ADHESION; CELL CULTURE; CELL LOSS; CELL VIABILITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; ISCHEMIA; LUNG ALVEOLUS EPITHELIUM; LUNG TRANSPLANTATION; ORGAN PRESERVATION; PRIORITY JOURNAL; REPERFUSION INJURY;

EID: 0033774822     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.89.4.1553     Document Type: Article

References (36)

1. Pneumocytes type II ultrastructural modifications after storage in preservation solutions for transplantation
2. Lung oxidant injury in a model of lung storage and extended reperfusion
3. Changes in alveolar oxygen and carbon dioxide concentration and oxygen consumption during lung preservation: The maintenance of aerobic metabolism during lung preservation
4. Evaluation of lung metabolism during successful twenty-four-hour canine lung preservation
5. Whence the lungs? A study to assess suitability of donor lungs for transplantation
6. Cell death in human lung transplantation: Apoptosis induction in human lungs during ischemia and after transplantation
7. Influence of cold preservation on the cytoskeleton of cultured pulmonary arterial endothelial cells
8. Donor lung preservation: Effect of cold preservation fluids on cultured pulmonary endothelial cells
9. Role of ICE-like proteases in endothelial cell hypoxic and reperfusion injury
10. Management of dysfunction in the transplanted lung. Experience with 7 clinical cases. Washington University Lung Transplant Group
11. Cold ischemia-induced damage to vascular endothelium results in permeability alterations in transplanted lungs
12. Pulmonary graft preservation: A worldwide survey of current clinical practice
13. Preconditioning human ventricular cardiomyocytes with brief periods of simulated ischaemia
14. Trehalose-containing solutions enhance preservation of cultured endothelial cells
15. A method for safe twelve-hour pulmonary preservation
16. The role of dextran 40 and potassium in extended hypothermic lung preservation for transplantation
17. Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes
18. The effect of low-potassium-dextran versus Euro-Collins solution for preservation of isolated type II pneumocytes
19. Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death
20. Lipid peroxidation and modification of lipid composition in an endothelial cell model of ischemia and reperfusion
21. + exchange activation
22. Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: The pH paradox and cytoprotection by glucose, acidotic pH, and glycine
23. Lung preservation: The importance of endothelial and alveolar type II cell integrity
24. New trends in lung preservation: A collective review
25. Status of lung transplantation
26. Rapid reperfusion causes stress failure in ischemic rat lungs
27. The primary localization of free radical generation after anoxia/reoxygenation in isolated endothelial cells
28. Heart-lung transplantation: Successful therapy for patients with pulmonary vascular disease
29. Amelioration of pulmonary allograft injury by administering a second rinse solution
30. The effect of dextran for hypothermic (10°C) preservation of human fetal lung fibroblasts
31. Methodology for the assessment of lung protection: Human pulmonary artery endothelial cell preservation using haemaccel
32. Successful outcome of lung transplantation is not compromised by the use of marginal donor lungs
33. Unilateral lung transplantation for pulmonary fibrosis
34. An in vitro model to study myocardial ischemic injury
35. Influence of intraalveolar oxygen concentration on lung preservation in a rabbit model
36. The superiority of an extracellular fluid solution over Euro-Collins' solution for pulmonary preservation