Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3845-3850

  Timonen, Juri M ^a   Nieminen, Riina M ^b   Sareila, Outi ^b   Goulas, Antonis ^b,c   Moilanen, Lauri J ^b   Haukka, Matti ^a   Vainiotalo, Pirjo ^a   Moilanen, Eeva ^b   Aulaskari, Paula H ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Anti inflammatory drugs; Coumarin; Inducible nitric oxide synthase; Interleukin 6; Nitric oxide; von Pechmann synthesis

Indexed keywords

3 FLUORO 7 HYDROXY 8 METHOXY 4 METHYL 2H BENZO 1 PYRAN 2 ONE; 7 HYDROXY 4 (2 FLUORO PHENYL) 2H BENZO 1 PYRAN 2 ONE; 7 HYDROXY 5 METHYL 4 PROPYL 2H BENZO 1 PYRAN 2 ONE; 7 HYDROXY 8 METHOXY 4 PHENYL 2H BENZO 1 PYRAN 2 ONE; 7 HYDROXY 8 METHOXY 4 PROPYL 2H BENZO 1 PYRAN 2 ONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; NITRIC OXIDE; NSC D 96019 1; NSC D 96021 1; NSC D 96022 1; NSC D 96023 1; NSC D 96024 1; NSC D 96154 1; NSC D 96155 1; PERCHLORIC ACID; RESORCINOL; UMBELLIFERONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; CYTOKINE PRODUCTION; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; NITRIC OXIDE SYNTHASE TYPE II; STRUCTURE-ACTIVITY RELATIONSHIP; UMBELLIFERONES;

EID: 80052946717     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.052     Document Type: Article

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