The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells

Journal of Natural Medicines

Volumn 63, Issue 1, 2009, Pages 15-20

  Nakamura, Tomonori ^a   Kodama, Naoko ^a   Oda, Manabu ^a   Tsuchiya, Shizuko ^a   Arai, Yu ^a   Kumamoto, Takuya ^a   Ishikawa, Tsutomu ^a   Ueno, Koichi ^a   Yano, Shingo ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Inducible nitric oxide synthase; Macrophage; Oxycoumarin; RAW264.7; Structure activity relationship

Indexed keywords

5,7 DIMETHOXYCOUMARIN; 5,7 DIOXYCOUMARIN; COUMARIN DERIVATIVE; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; OXYCOUMARIN DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BALANOPHORA ABBREVIATA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; ENZYME INHIBITION; FERULA FUKANENSIS; LEDEBOURIELLA SESELOIDES; MACROPHAGE; MEDICINAL PLANT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; COUMARINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57049111621     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-008-0268-6     Document Type: Article

References (15)

1. IA Khan MV Kulkarni M Gopal MS Shahabuddin CM Sun 2005 Synthesis and biological evaluation of novel angularly fused polycyclic coumarins Bioorg Med Chem Lett 15 3584 3587
2. A Lorico BH Long 1993 Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II Eur J Cancer 29A 1985 1991
3. F Rosskopf J Kraus G Franz 1992 Immunological and antitumor effects of coumarin and some derivatives Pharmazie 47 139 142
4. CJ Wang YJ Hsieh CY Chu YL Lin TH Tseng 2002 Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin Cancer Lett 183 163 168
5. US Weber B Steffen CP Siegers 1998 Antitumor-activities of coumarin, 7-hydroxy-coumarin and its glucuronide in several human tumor cell lines Res Commun Mol Pathol Pharmacol 99 193 206
6. J Tai S Cheung 2007 Anti-proliferative and antioxidant activities of Saposhnikovia divaricata Oncol Rep 18 227 234
7. T Motai A Daikonya S Kitanaka 2004 Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects J Nat Prod 67 432 436
8. T Motai S Kitanaka 2004 Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects Chem Pharm Bull (Tokyo) 52 1215 1218
9. A Hosokawa M Sumino T Nakamura S Yano T Sekine N Ruangrungsi K Watanabe F Ikegami 2004 A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression Chem Pharm Bull (Tokyo) 52 1265 1267
10. CC Wang JE Lai LG Chen KY Yen LL Yang 2000 Inducible nitric oxide synthase inhibitors of Chinese herbs. Part 2: naturally occurring furanocoumarins Bioorg Med Chem 8 2701 2707
11. T Akaike H Maeda 2000 Nitric oxide and virus infection Immunology 101 300 308
12. H Kolb V Kolb-Bachofen 1998 Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator? Immunol Today 19 556 561
13. CV Suschek O Schnorr V Kolb-Bachofen 2004 The role of iNOS in chronic inflammatory processes in vivo: is it damage-promoting, protective, or active at all? Curr Mol Med 4 763 775
14. N Miyasaka Y Hirata 1997 Nitric oxide and inflammatory arthritides Life Sci 61 2073 2081
15. A Kaminski CB Pohl C Sponholz N Ma C Stamm B Vollmar G Steinhoff 2004 Up-regulation of endothelial nitric oxide synthase inhibits pulmonary leukocyte migration following lung ischemia-reperfusion in mice Am J Pathol 164 2241 2249