Development of novel conformation-constrained cytotoxic derivatives of cheliensisin A by embedment of small heterocycles

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4238-4244

  Deng, Xu ^a,c   Su, Jia ^a   Zhao, Yu ^a   Peng, Li Yan ^a   Li, Yan ^a   Yao, Zhu Jun ^b   Zhao, Qin Shi ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Anticancer; Cheliensisin A; Cytotoxicity; Derivative; Structure activity relationship

Indexed keywords

2 BENZYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL(5H,6H)OXAZOLINE; 2 METHYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL(5H,6H)OXAZOLINE; 2 PHENYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL OXAZOLE; 2 PHENYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL(5H,6H)OXAZOLINE; 2 PROPENYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL OXAZOLE; 2 PROPENYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL(5H,6H)OXAZOLINE; 2 STYRYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL OXAZOLE; 2 STYRYL 4 (5' ACETOXYL 5',6' DIHYDRO 2'H PYRAN 2' ON 6' YL) 5 PHENYL(5H,6H)OXAZOLINE; 7 BENZOYLAMINO 8 HYDROXYL CHELIENSISIN A; 7 CINNAMOYLAMINO 8 HYDROXYL CHELIENSISIN A; 7 HYDROXYL 8 PHENYLAMINO CHELIENSISIN A; 7 PHENYLACETYLAMINO 8 HYDROXYL CHELIENSISIN A; 7,8 ACETONYL DIOXA CHELIENSISIN A; 7,8 CARBONATE DIOXA CHELIENSISIN A; 7,8 DIHYDROXYL CHELIENSISIN A; 7,8 EN CHELIENSISIN A; CHELIENSISIN A DERIVATIVE; CISPLATIN; OXAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CYTOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; SYNTHESIS; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; HETEROCYCLIC COMPOUNDS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PYRONES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 80052942838     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.028     Document Type: Article

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