Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response

Science Translational Medicine

Volumn 3, Issue 100, 2011, Pages

  Wang, Xiaoyin ^a   Takagawa, Junya ^a,c   Lam, Viola C ^b   Haddad, Daniel J ^a   Tobler, Diana L ^b   Mok, Pamela Y ^a   Zhang, Yan ^a,d   Clifford, Brian T ^a   Pinnamaneni, Kranthi ^a,e   Saini, Shereen A ^a,f   Su, Robert ^a,g   Bartel, Maya J ^a   Sievers, Richard E ^a   Carbone, Larry ^a   Kogan, Scott ^b   Yeghiazarians, Yerem ^a,b   Hermiston, Michelle ^b   Springer, Matthew L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Imizu City Hospital   (Japan)

^d Silver Creek Pharmaceuticals   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Analytical Sciences   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; INTERLEUKIN 1; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW; BONE MARROW CELL; CELL COMPOSITION; CONTROLLED STUDY; DONOR; HEART INFARCTION; IMMUNE RESPONSE; MALE; MOUSE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BONE MARROW TRANSPLANTATION; C57BL MOUSE; ECHOCARDIOGRAPHY; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM; METHODOLOGY; PATHOLOGY;

ANIMALS; BONE MARROW TRANSPLANTATION; ECHOCARDIOGRAPHY; FLOW CYTOMETRY; INTERLEUKIN-1; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; TISSUE DONORS;

EID: 80052938037     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002814     Document Type: Article

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39. Acknowledgments: We thank R. Lee for helpful discussion and advice; S. Peck (University of California, San Francisco, Biological Imaging Development Center) for help with confocal imaging; and J. Ye, B. Cook, and S. Mihardja for technical and physical assistance. Funding: This work was supported by NIH grants R01 HL086917, R03 EB005802, and R21 HL097129, and University of California Discovery Grant bio04-10481. Author contributions: X.W. helped conceive and performed most of the experiments and data analysis, and J.T. performed the preliminary study, with technical help from V.C.L., D.J.H., D.L.T., P.Y.M., Y.Z., B.T.C., S.A.S., K.P., R.S., M.J.B., and R.E.S. M.L.S. conceived the project and supervised most of the experiments. M.H., S.K., Y.Y., and L.C. provided collaborative experimental support and ideas for the project. X.W. and M.L.S. wrote the manuscript. Competing interests: The authors declare that they have no competing interests.