Selection of an M184V mutation in the cerebrospinal fluid of a treatment-naive HIV-infected individual starting darunavir-based therapy

Antiviral Therapy

Volumn 16, Issue 6, 2011, Pages 931-935

  Cornelissen, Marion ^a   Back, Nicole K T ^b   Burger, David M ^c   Blom, Petra ^b   Portegies, Peter ^b   Prins, Jan M ^b   Van Der Valk, Marc ^b  

^a Center for Infection and Immunity Amsterdam   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CLARITHROMYCIN; DARUNAVIR; EMTRICITABINE; ETHAMBUTOL; HEPATITIS B CORE ANTIBODY; RIFABUTIN; RITONAVIR; RNA DIRECTED DNA POLYMERASE; TENOFOVIR; ZIDOVUDINE;

ADULT; AMNESIA; ARTICLE; ATYPICAL MYCOBACTERIOSIS; BEHAVIOR DISORDER; CASE REPORT; CD4 LYMPHOCYTE COUNT; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; DRUG BLOOD LEVEL; EPSTEIN BARR VIRUS; GENE MUTATION; GENOTYPE; HEART LEFT VENTRICLE FAILURE; HEPATITIS B; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LUMBAR PUNCTURE; LUNG INFECTION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PNEUMOSEPSIS; PRIORITY JOURNAL; RESPIRATORY FAILURE; SEROLOGY; VIRUS LOAD; VIRUS MYOCARDITIS;

ANTI-HIV AGENTS; DRUG RESISTANCE, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; MUTATION; PHYLOGENY; POL GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; RNA, VIRAL; SULFONAMIDES; VIRAL LOAD;

EID: 80052924838     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1781     Document Type: Article

References (12)

1. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. (Updated 2009. Accessed 12 April 2011.) Available from www.aidsinfo.nih.gov/contentfiles/adultandadolescentgl.pdf
2. Thompson MA, Aberg JA, Cahn P, et al. Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA Panel. JAMA 2010; 304:321-333.
3. Johnson VA, Brun-Vezinet F, Clotet B, et al. Update of the drug resistance mutations in HIV-1: December 2009. Top HIV Med 2009; 17:138-145.
4. Yilmaz A, Izadkhashti A, Price RW, et al. Darunavir concentrations in cerebrospinal fluid and blood in HIV-1-infected individuals. AIDS Res Hum Retroviruses 2009; 25:457-461.
5. Boom R, Sol CJ, Salimans MM, Jansen CL, Wertheim-van Dillen PM, van der Noordaa J. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990; 28:495-503. (Pubitemid 20078123)
6. van der Kuyl AC, Zorgdrager F, Jurriaans S, et al. Incidence of human immunodeficiency virus type 1 dual infections in Amsterdam, the Netherlands, during 2003-2007. Clin Infect Dis 2009; 48:973-978.
7. Salazar-Gonzalez JF, Bailes E, Pham KT, et al. Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing. J Virol 2008; 82:3952-3970. (Pubitemid 351521232)
8. Canestri A, Lescure F, Jaureguiberry S, et al. Discordance between cerebral spinal fluid and plasma HIV replication in patients with neurological symptoms who are receiving suppressive antiretroviral therapy. Clin Infect Dis 2010; 50:773-778.
9. van Lelyveld SF, Nijhuis M, Baatz F, et al. Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid. Clin Infect Dis 2010; 50:387-390.
10. Letendre S, FitzSimons C, Ellis R, et al. Correlates of CSF viral loads in 1221 volunteers of the CHARTER Cohort. 17th Conference on Retroviruses and Opportunistic Infections. 16-19 February 2010, San Francisco, CA, USA. Abstract 172.
11. Letendre S, Marquie-Beck J, Capparelli E, et al. Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol 2008; 65:65-70.
12. Tamura K, Dudley J, Nei M, Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evo 2007; 24:1596-1599. (Pubitemid 47236692)