Influence of BMI on risk of miscarriage after single blastocyst transfer

Human Reproduction

Volumn 26, Issue 10, 2011, Pages 2642-2650

  Rittenberg, Vivian ^a   Sobaleva, Sviatlana ^a   Ahmad, Alyaa ^a   Oteng Ntim, Eugene ^a   Bolton, Virginia ^a   Khalaf, Yacoub ^a   Braude, Peter ^a,b   El Toukhy, Tarek ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

assisted reproduction technology; BMI; IVF; Miscarriage; obesity

Indexed keywords

ADULT; AGE; ARTICLE; BLASTOCYST; BODY MASS; CONTROLLED STUDY; DISEASE DURATION; FEMALE; FEMALE INFERTILITY; GESTATIONAL AGE; HUMAN; INFERTILITY THERAPY; MAJOR CLINICAL STUDY; PREGNANCY; SINGLE BLASTOCYST TRANSFER; SMOKING; SPONTANEOUS ABORTION; TREATMENT OUTCOME;

EID: 80052899349     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/der254     Document Type: Article

References (75)

1. Andrico S, Gambera A, Specchia C, Pellegrini C, Falsetti L, Sartori E. Leptin in functional hypothalamic amenorrhoea. Hum Reprod 2002; 17:2043-2048.
2. Bahceci M, Ulug U. Does underlying infertility aetiology impact on first trimester miscarriage rate following ICSI? A preliminary report from 1244 singleton gestations. Hum Reprod 2005;20:717-721. (Pubitemid 40425499)
3. Balen AH, Anderson RA. Impact of obesity on female reproductive health: British Fertility Society, Policy and Practice Committee guidelines. Hum Fertil 2007;10:195-206. (Pubitemid 350215066)
4. Balen AH, Seang-Lin Tan SL, MacDougall J, Jacobs HS. Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum Reprod 1993;8:959-964. (Pubitemid 23193697)
5. Bellver J, Rossal LP, Bosch E, Zuniga A, Corona JT, Melendez F, Gomez E, Simon C, Remohi J, Pellicer A. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil Steril 2003;79:1136-1140. (Pubitemid 36547851)
6. Bellver J, Melo M, Bosch E, Serra V, Remohi J, Pellicer A. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril 2007;88:446-451. (Pubitemid 47212154)
7. Bellver J, Ayllon Y, Ferrando M, Melo M, Goyri E, Pellicer A, Remohi J, Meseguer M. Female obesity and impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril 2010;93:447-454.
8. Bianco K, Caughey AB, Shaffer BL, Davis R, Norton ME. History of miscarriage and increased incidence of fetal aneuploidy in subsequent pregnancy. Obstet and Gynecol 2006;107:1098-102.
9. Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 1998;83:1059-1066. (Pubitemid 28520935)
10. Bungum M, Bungum L, Humaidan P, Yding Andersen C. Day 3 versus day 5 embryo transfer: a prospective randomized study. Reprod Biomed Online 2003;7:98-104. (Pubitemid 36874418)
11. Carrell DT, Jones KP, Peterson CM, Aoki V, Emery BR, Campbell BR. Body mass index is inversely related to intrafollicular HCG concentration, embryo quality and IVF outcome. Reprod Biomed Online 2001;3:109-111.
12. Castellucci M, De Matteis R, Meisser A, Cancello R, Monsurro V, Islami D, Sarzani R, Marzioni D, Cinti S, Bischof P. Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. Mol Hum Reprod 2000;6:951-958.
13. Catalano PM, Ehrenberg HM. The short-and long-term implications of maternal obesity on the mother and her offspring. BJOG 2006; 113:1126-1133. (Pubitemid 44401205)
14. Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 1998; 13:1502-1505. (Pubitemid 28310484)
15. Craig LB, Ke RW, Kutteh WH. Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss. Fertil Steril 2002; 78:487-490.
16. De Neubourg D, Gerris J, Mangelschots K, Van Royen E, Vercruyssen M, Elseviers M. Single top quality embryo transfer as a model for prediction of early pregnancy outcome. Hum Reprod 2004;19:1476-1479. (Pubitemid 38807727)
17. Dechaud H, Anahory T, Reyftmann L, Loup V, Hamamah S, Hedon B. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol 2006;127:88-93. (Pubitemid 43947436)
18. El-Toukhy T, Khalaf Y, Hart R, Taylor A, Braude P. Young age does not protect against the adverse effects of reduced ovarian reserve-an eight year study. Hum Reprod 2002;24:2642-2648.
19. El-Toukhy T, Coomarasamy A, Khairy M, Sunkara K, Seed P, Khalaf Y, Braude P. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril 2008;89:832-839. (Pubitemid 351491224)
20. El-Toukhy T, Kamal A, Wharf E, Grace J, Bolton V, Khalaf Y, Braude P. Reduction of the multiple pregnancy rate in a preimplantation genetic diagnosis programme after introduction of single blastocyst transfer and cryopreservation of blastocysts biopsied on Day 3. Hum Reprod 2009;17:1519-1524.
21. Enriori PJ, Evans AE, Sinnayah P, Cowley MA. Leptin resistance and obesity. Obesity 2006;14(Suppl 5):254S-258S.
22. ESHRE Capri Workshop Group. Nutrition and reproduction in women. Hum Reprod Update 2006;12:193-207.
23. Fedorcsak P, Storeng R, Dale PO, Tanbo T, Abyholm T. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 2000;79:43-48. (Pubitemid 30045290)
24. Fedorcsak P, Dale PO, Storeng R, Ertzeid G, Bjercke S, Oldereid N, Omland AK, Abyholm T, Tanbo T. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 2004; 19:2523-2528. (Pubitemid 39481277)
25. Gardner DK, Schoolcraft WB. In vitro culture of human blastocyst. In: Jansen R, Mortimer D (eds), Towards Reproductive Certainty: Infertility and Genetics Beyond 1999. Carnforth: Parthenon Press, 378-388.
26. Gonzalez RR, Caballero-Campo P, Jasper M, Mercader A, Devoto L, Pellicer A, Simon C. Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst. J Clin Endocrinol Metab 2000;85:4883-4888. (Pubitemid 32157681)
27. Giudice LC. Endometrium in PCOS: implantation and predisposition to endocrine CA. Best Pract Res Clin Endocrinol Metab 2006;20:235-244. (Pubitemid 43842928)
28. Hamilton-Fairley D, Kiddu D, Watson H, Peterson C, Franks S. Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br J Obstet Gynaecol 1992;99:128-131.
29. Hourvitz A, Lerner-Geva L, Elizur SE, Baum M, Levron J, David B, Meirow D, Yaron R, Dor J. Role of embryo quality in predicting early pregnancy loss following assisted reproductive technology. Reprod Biomed Online 2006; 13:504-509. (Pubitemid 44548785)
30. Hughes E, Brennan B. Does cigarette smoking impair natural or assisted fecundity? Fertil Steril 1996;66:679-689. (Pubitemid 26357564)
31. International Obesity Task Force and European Association for the Study of Obesity. Obesity in Europe. The Case for Action. London, 2002. Available at: http://www.iotf.org/media/euobesity.pdf (27 September 2010, date last accessed).
32. Kaufman R, Menezo Y, Hazout A, Nicollet B, DuMont M, Servy E. Cocultured blastocyst cryopreservation: experience of more than 500 transfer cycles. Fertil Steril 1995;64:1125-1129.
33. Kawamura K, Sato N, Fukuda J, Kodama H, Kumagai J, Tanikawa H, Murata M, Tanaka T. The role of leptin during the development of mouse preimplantation embryos. Mol Cell Endocrinol 2003;202:185-189. (Pubitemid 36593410)
34. Khalaf Y, El-Toukhy T, Coomarasamy A, Kamal A, Bolton V, Braude P. Selective single blastocyst transfer reduces the multiple pregnancy rate and increases pregnancy rates: a pre-and post-intervention study. Br J Obstet Gynaecol 2008;115:385-390.
35. Khaund A, Lumsden MA. Impact of fibroids on reproductive function. Best Pract Res Clin Obstet Gynaecol 2008;22:749-760.
36. Kupka MS, Dorn C, Montag M, Felberbaum RE, Van der Ven A, Kulczycki A, Friese K. Previous miscarriages influence IVF and intracytoplasmic sperm injection pregnancy outcome. Reprod Biomed Online 2004;8:349-357. (Pubitemid 38380377)
37. Lage M, Garcia-Mayor RV, Tome MA, Cordido F, Valle-Inclan F, Considine RV, Caro JF, Dieguez C, Casanueva FF. Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion. Clin Endocrinol 1999; 50:211-216. (Pubitemid 29100008)
38. Lambers MJ, Mager E, Goutbeek J, McDonnell J, Homburg R, Schats R, Hompes PG, Lambalk CB. Factors determining early pregnancy loss in singleton and multiple implantations. Hum Reprod 2007; 22:275-279. (Pubitemid 44942697)
39. Landres IV, Milki AA, Lathi RB. Karyotype of miscarriages in relation to maternal weight. Hum Reprod 2010;25:1123-1126.
40. Lashen H, Fear H, Sturdee D. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case control study. Hum Reprod 2004;19:1644-1646. (Pubitemid 38997196)
41. Lok I, Neugebauer R. Psychological morbidity following miscarriage. Best Pract Res Clin Obstet Gynaecol 2007;21:229-247. (Pubitemid 46478037)
42. Maconochie N, Doyle P, Prior S, Simmons R. Risk factors for first trimester miscarriage-results from a UK-population-based case-control study. BJOG 2007;114:170-186. (Pubitemid 46089446)
43. Maheshwari A. Overweight and obesity in infertility: cost and consequences. Hum Reprod Update 2010;16:229-230.
44. Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology-a systematic review. Hum Reprod Update 2007;13:433-444. (Pubitemid 47299850)
45. Matalliotakis I, Cakmak H, Sakkas D, Mahutte N, Koumantakis G, Arici A. Impact of body mass index on IVF and ICSI outcome: a retrospective study. Reprod Biomed Online 2008;16:778-783. (Pubitemid 351865339)
46. Matias A, La Sala G, Blickstein I. Early loss rates of entire pregnancies after assisted reproduction is lower in twin than in singleton pregnancies. Fertil Steril 2007;88:1452-1454. (Pubitemid 350030080)
47. McClamrock H. The great weight debate: do elevations in body mass index (BMI) exert a negative extraovarian effect on in vitro fertilization outcome? Fertil Steril 2008;89:1609-1610. (Pubitemid 351749613)
48. Metwally M, Cutting R, Tipton A, Skull J, Ledger WL, Li TC. Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reprod Biomed Online 2007;15:532-538. (Pubitemid 350167075)
49. Metwally M, Ong KJ, Ledger WL, Li TC. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril 2008a; 90:714-726.
50. Metwally M, Ledger WL, Li TC. Reproductive endocrinology and clinical aspects of obesity in women. Ann N Y Acad Sci 2008b;1127:140-146. (Pubitemid 351563093)
51. Metwally M, Amer S, Li TC, Ledger WL. An RCT of metformin versus orlistat for the management of obese anovulatory women. Hum Reprod 2009;24:966-975.
52. Mitchell M, Armstrong DT, Robker RL, Norman RJ. Adipokines: implications for female fertility and obesity. Reproduction 2005; 130:583-597. (Pubitemid 41646045)
53. Orvieto R, Nahum R, Meltcer S, Homburg R, Rabinson J, Anteby E, Ashkenazi J. Ovarian stimulation in polycystic ovary syndrome patients: the role of body mass index. Reprod Biomed Online 2009; 18:333-336.
54. Papanikolaou E, D'Haeseleer E, Verheyen G, Van de Velde H, Van Sterteghem A, Devroey P, Tournaye P. Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study. Hum Reprod 2005; 20:3198-3203. (Pubitemid 41662678)
55. Papanikolaou E, Camus M, Fatemi H, Tournaye H, Verheyen G, Van Steirteghem A, Devroey P. Early pregnancy loss is significantly after day 3 single embryo transfer than after day 5 single blastocyst transfer in GnRH antagonist stimulated IVF cycles. Reprod BioMed Online 2006; 12:60-65. (Pubitemid 43115119)
56. Papanikolaou E, Kolibianakis E, Tournaye H, Venetis C, Fatemi H, Tarlatzis B, Devroey P. Live birth rates after transfer of equal number of blastocyst and cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod 2008;23:91-99. (Pubitemid 351767314)
57. Qiao J, Feng H. Extra-and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Hum Reprod Update 2011;17:17-33.
58. Rich-Edwards JW, Goldman MB, Willett WC, Hunter DJ, Stampfer MJ, Colditz GA, Manson JE. Adolescent body mass index and infertility caused by ovulatory disorder. Am J Obstet Gynecol 1994;171: 171-177. (Pubitemid 24254437)
59. Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril 2007;87:553-559.
60. Samy N, Hashim M, Sayed M, Said M. Clinical significance of inflammatory markers in polycystic ovary syndrome: their relationship to insulin resistance and body mass index. Dis Markers 2009;26:163-170.
61. Schieve LA, Tatham L, Peterson HB, Toner J, Jeng G. Spontaneous abortion among pregnancies conceived using assisted reproductive technology in the United States. Obstet Gynecol 2003;101:959-967. (Pubitemid 36561262)
62. Stothard K, Tennant P, Bell R, Rankin J. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 2009;301:636-650.
63. Styne-Gross A, Elkind-Hirsch K, Scott R. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation. Fertil Steril 2005; 83:1629-1634. (Pubitemid 40824793)
64. Tehrani Nejod E, Saedi T, Saedi S, Rashidi BH, Nekoo ZA, Jahangiri N. Comparison of in vitro fertilization success in patients with polycystic ovary syndrome and tubal factor. Gynecol Endocrinol 2011;27: 117-120.
65. Tian L, Shen H, Lu Q, Norman RJ, Wang J. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment. J Clin Endocrinol Metab 2007;92:1430-1433. (Pubitemid 46556421)
66. Van der Spuy ZM, Dyer SL. The pathogenesis of infertility and early pregnancy loss in polycystic ovary syncrome. Best Pract Res Clin Obstet Gynaecol 2004;18:755-771.
67. Van der Steeg JW, Steures P, Eijkemans MJ, Habbema JD, Hompes PG, Michgelsen HW, Van der Heijden PF, Bossuyt PM, Van der Veen F, Mol BW. Predictive value of pregnancy history in subfertile couples: results from a nationwide cohort study in the Netherlands. Fertil Steril 2008;90:521-527.
68. Veleva Z, Tiitinen A, Vilska S, Hydén-Granskog C, Tomás C, Martikainen H, Tapanainen JS. High and low BMI increase the risk of miscarriage after IVF/ICSI and FET. Hum Reprod 2008; 23:878-884.
69. Vilarino F, Christofolini D, Rodrigues D, de Souza A, Christofolini J, Bianco B, Barbosa C. Body mass index and fertility: is there a correlation with human reproduction outcomes? Gynecol Endocrinol 2011;27:232-236.
70. Wang JX, Davies M, Norman RJ. Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. BMJ 2000; 321:1320-1321.
71. Wang JX, Norman RJ, Wilcox AJ. Incidence of spontaneous abortion among pregnancies produced by assisted reproductive technology. Hum Reprod 2004;19:272-277. (Pubitemid 38219992)
72. Winter E, Wang J, Davies MJ, Norman R. Early pregnancy loss following assisted reproductive technology treatment. Hum Reprod 2002; 17:3220-3223. (Pubitemid 35469277)
73. Wittemer C, Ohl J, Bailly M, Bettahar-Lebugle K, Nisand I. Does body mass index of infertile women have an impact on IVF procedure and outcome? J Assist Reprod Genet 2000;17:547-552. (Pubitemid 32066673)
74. World Health Organisation. Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. WHO Technical ReportSeries894.Geneva,Switzerland:WorldHealthOrganisation,2000.
75. Yang D, Sun Z, Deng C, Yu Q, He FF. Factors analysis of spontaneous abortion after thawed-vitrified blastocysts transfer. J Reprod Contracept 2008;19:35-42.