Evaluation of epidemiological, clinical, and pathological features of neuroaxonal dystrophy in Quarter Horses

Journal of the American Veterinary Medical Association

Volumn 239, Issue 6, 2011, Pages 823-833

  Aleman, Monica ^a   Finno, Carrie J ^a   Higgins, Robert J ^a   Puschner, Birgit ^a   Gericota, Barbara ^a   Gohil, Kishorchandra ^a   LeCouteur, Richard A ^a   Madigan, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOPHEROL TRANSFER PROTEIN; ALPHA-TOCOPHEROL TRANSFER PROTEIN; CARRIER PROTEIN; MESSENGER RNA;

AGING; ALPHA TOCOPHEROL DEFICIENCY; ANIMAL; ANIMAL DISEASE; ARTICLE; DIET SUPPLEMENTATION; ELECTROENCEPHALOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HORSE; HORSE DISEASE; MALE; METABOLISM; NEUROAXONAL DYSTROPHY; PATHOLOGY; PHYSIOLOGY; PREGNANCY;

AGING; ANIMALS; CARRIER PROTEINS; DIETARY SUPPLEMENTS; ELECTROENCEPHALOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; HORSE DISEASES; HORSES; MALE; NEUROAXONAL DYSTROPHIES; PREGNANCY; RNA, MESSENGER; VITAMIN E; VITAMIN E DEFICIENCY;

ANIMALIA; EQUIDAE;

EID: 80052892201     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.239.6.823     Document Type: Article

References (66)

1. Jellinger K. Neuroaxonal dystrophy: its natural history and related disorders. Prog Neuropathol 1973;2:129-180.
2. Bouley DM, McIntire JJ, Harris BT, et al. Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy. J Comp Pathol 2006;134:160-170.
3. Lowe J, Lennox G, Leigh PN. Disorders of movement and system degenerations. In: Graham DI, Lantos PL, eds. Greenfield's neuropathology. New York: Oxford Unversity Press Inc, 1997;336-339.
4. Carrilho I, Santos M, Guimaraes A, et al. Infantile neuroaxonal dystrophy: what's most important for the diagnosis? Eur Paediatr Neurol 2008;12:491-500.
5. Wu Y, Jiang Y, Gao Z, et al. Clinical study and PLA2G6 mutation screening analysis in Chinese patients with infantile neuroaxonal dystrophy. Eur J Neurol 2009;16:240-245.
6. Gordon N. Infantile neuroaxonal dystrophy (Seitelberger's disease). Dev Med Child Neurol 2002;44:849-851.
7. Nuttall WO. Ovine neuroaxonal dystrophy in New Zealand. N Z Vet J 1988;36:5-7.
8. Harper PA, Morton AG. Neuroaxonal dystrophy in Merino sheep. Aust Vet 1991;68:152-153.
9. Diaz JV, Duque C, Geisel R. Neuroaxonal dystrophy in dogs: case report in 2 litters of Papillon puppies. J Vet Intern Med 2007;21:531-534.
10. Nibe K, Kita C, Morozumi M, et al. Clinicopathological features of canine neuroaxonal dystrophy and cerebellar cortical abiotrophy in Papillon and Papillon-related dogs. J Vet Med Sci 2007;69:1047-1052.
11. Cork LC, Troncoso JC, Price DL, et al. Canine neuroaxonal dystrophy. J Neuropathol Exp Neurol 1983;42:286-296.
12. Woodard JC, Collins GH, Hessler JR. Feline hereditary neuroaxonal dystrophy. Am J Pathol 1974;74:551-566.
13. Carmichael KP, Howerth EW, Oliver JE, et al. Neuroaxonal dystrophy in a group of related cats. J Vet Diagn Invest 1993;5:585-590.
14. Beech J. Neuroaxonal dystrophy of the accessory cuneate nucleus in horses. Vet Pathol 1984;21:384-393.
15. Beech J, Haskins M. Genetic studies of neuraxonal dystrophy in the Morgan. Am J Vet Res 1987;48:109-113.
16. Baumgartner W, Frese K, Elmadfa I. Neuroaxonal dystrophy associated with vitamin E deficiency in two Haflinger horses. J Comp Pathol 1990;103:114-119.
17. Brosnahan MM, Holbrook TC, Ritchey JW. Neuroaxonal dystrophy associated with cerebellar dysfunction in a 5-monthold Pony of the Americas colt. J Vet Intern Med 2009;23:1303-1306.
18. Khateeb S, Flusser H, Ofir R, et al. PLA2G6 mutation underlies infantile neuroaxonal dystrophy. Am J Hum Genet 2006;79:942-948.
19. Morgan NV, Westaway SK, Morton JE, et al. PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Nat Genet 2006;38:752-754.
20. Zhou B, Westaway SK, Levinson B, et al. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Nat Genet 2001;28:345-349.
21. Sung JH, Mastri AR, Park SH. Axonal dystrophy in the gracile nucleus in children and young adults. Reappraisal of the incidence of associated diseases. J Neuropathol Exp Neurol 1981;40:27-45.
22. Sung JH, Stadlan EM. Neuroaxonal dystrophy in congenital biliary atresia. J Neuropathol Exp Neurol 1966;25:118-119.
23. Cordy DR, Richards WP, Bradford GE. Systemic neuroaxonal dystrophy in Suffolk sheep. Acta Neuropathol 1967;8:133-140.
24. Chrisman CL, Cork LC, Gamble DA. Neuroaxonal dystrophy of Rottweiler dogs. J Am Vet Med Assoc 1984;184:464-467.
25. Sacre BJ, Cummings JF, de Lahunta A. Neuroaxonal dystrophy in a Jack Russel terrier pup resembling human infantile neuroaxonal dystrophy. Cornell Vet 1993;83:133-142.
26. Clark RG, Hartley WJ, Burgess GS, et al. Suspected inherited cerebellar neuroaxonal dystrophy in collie sheep dogs. N Z Vet J 1982;30:102-103.
27. Franklin RJ, Jeffery ND, Ramsey IK. Neuroaxonal dystrophy in a litter of papillon pups. J Small Anim Pract 1995;36:441-444.
28. Blakemore WF, Palmer AC. Nervous disease in the Chihuahua characterized by axonal swellings. Vet Rec 1985;117:498-499.
29. Blythe LL, Hultgren BD, Craig AM, et al. Clinical, viral, and genetic evaluation of equine degenerative myeloencephalopathy in a family of Appaloosas. J Am Vet Med Assoc 1991;198:1005-1013.
30. Nelson JS, Fitch CD, Fischer VW, et al. Progressive neuropathological lesions with vitamin E deficiency in mammals. J Neuropathol Exp Neurol 1978;37:666.
31. Nelson JS, Fitch CD, Fischer VW, et al. Progressive neuropathologic lesions in vitamin E-deficient rhesus monkeys. J Neuropathol Exp Neurol 1981;40:166-186.
32. Dill SG, Kallfelz FA, de Lahunta A, et al. Serum vitamin E and blood glutathione peroxidase values of horses with degenerative myeloencephalopathy. Am J Vet Res 1989;50:166-168.
33. Adams AP, Collatos C, Fuentealba C, et al. Neuroaxonal dystrophy in a two-year-old Quarter Horse filly. Can Vet J 1996;37:43-44.
34. Fox J, Duncan R, Friday P, et al. Cerebello-olivary and lateral (accessory) cuneate degeneration in a juvenile American miniature horse. Vet Pathol 2000;37:271-274.
35. Siso I, Ferrer I, Pumarola M. Abnormal synaptic protein expression in two Arabian horses with equine degenerative myeloencephalopathy. Vet J 2003;166:238-243.
36. Montali RJ, Bush M, Sauer RM, et al. Spinal ataxia in zebras. Comparison with the wobbler syndrome of horses. Vet Pathol 1974;11:68-78.
37. Scarratt WK, Saunders GK, Sponenberg DP, et al. Degenerative myelopathy in two equids. Equine Vet Sci 1985;5:139-142.
38. Liu SK, Dolensek EP, Adams CR, et al. Myelopathy and vitamin E deficiency in six Mongolian wild horses. J Am Vet Med Assoc 1983;183:1266-1268.
39. Miller MM, Collatos C. Equine degenerative myeloencephalopathy. Vet Clin North Am Equine Pract 1997;13:43-52.
40. Dill SG, Correa MT, Erb HN, et al. Factors associated with the development of equine degenerative myeloencephalopathy. Am J Vet Res 1990;51:1300-1305.
41. Nappert G, Vrins A, Breton L, et al. A retrospective study of nineteen ataxic horses. Can Vet J 1989;30:802-806.
42. Blythe LL, Craig AM, Lassen ED, et al. Serially determined plasma 4-tocopherol concentrations and results of the oral vitamin E absorption test in clinically normal horses and in horses with degenerative myeloencephalopathy. Am J Vet Res 1991;52:908-911.
43. Jahns H, Callanan JJ, McElroy MC, et al. Age-related and nonage-related changes in 100 surveyed horse brains. Vet Pathol 2006;43:740-750.
44. Lunn DP, Mayhew IG. The neurological evaluation of horses. Equine Vet Educ 1989;1:94-101.
45. Williams DC, Aleman M, Holliday TA, et al. Qualitative and quantitative characteristics of the electroencephalogram in normal horses during spontaneous drowsiness and sleep. J Vet Intern Med 2008;22:630-638.
46. Melton LA, Tracy ML, Moller G. Screening trace elements and electrolytes in serum by inductively-coupled palsma emission spectrometry. Clin Chem 1990;36:247-250.
47. Holstege DM, Scharberg DL, Tor ER, et al. A rapid multiresidue screen for organophosphorus, organochlorine, and N-methyl carbamate insecticides in plant and animal tissues. J Assoc Off Anal Chem 1994;77:1263-1274.
48. Gohil K, Oommen S, Quach HT, et al. Mice lacking alphatocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system. Brain Res 2008;1201:167-176.
49. Henneke DR, Potter GD, Kreider JL, et al. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J 1983;15:371-372.
50. Hintz HF. Nutrition and equine performance. J Nutr 1994;124:2723S-2729S.
51. Hahn CN, Handel I, Green SL, et al. Assessment of the utility of using intra-and intervertebral minimum sagittal diameter ratios in the diagnosis of cervical vertebral malformation in horses. Vet Radiol Ultrasound 2008;49:1-6.
52. Mayhew IG, Donawick WJ, Green SL, et al. Diagnosis and prediction of cervical vertebral malformation in Thoroughbred foals based on semi-quantitative radiographic indicators. Equne Vet J 1993;25:435-440.
53. Cummings JF, de Lahunta A, George C, et al. Equine motor neuron disease: a preliminary report. Cornell Vet 1990;80:357-379.
54. McFarlance D. Advantages and limitations of the equine disease, pituitary pars intermedia dysfunction as a model of spontaneous dopaminergic neurodegenerative disease. Ageing Res Rev 2007;6:54-63.
55. Mayhew IG, Brown CM, Stowe HD, et al. Equine degenerative myeloencephalopathy: a vitamin E deficiency that may be familial. J Vet Intern Med 1987;1:45-50.
56. Mayhew IG, de Lahunta A, Whitlock RH, et al. Equine degenerative myeloencephalopathy. J Am Vet Med Assoc 1977;170:195-201.
57. Gandini G, Fatzer R, Mariscoli M, et al. Equine degenerative myeloencephalopathy in five Quarter Horses: clinical and neuropathological findings. Equine Vet J 2004;36:83-85.
58. Siso I, Ferrer I, Pumarola M. Juvenile neuroaxonal dystrophy in a Rottweiler: accumulation of synaptic proteins in dystrophic axons. Neuropathol 2001;102:501-504.
59. Nibe K, Nakayama H, Uchida K. Immunohistochemical features of dystrophic axons in Papillon dogs with neuroaxonal dystrophy. Vet Pathol 2009;46:474-483.
60. Sayre LM, Perry G, Smith MA. Oxidative stress and neurotoxicity. Chem Res Toxicol 2008;21:172-188.
61. Gohil K, Azzi A. Reply to drug insight: antioxidant therapy in inherited ataxias. Nat Clin Pract Neurol 2008;4:E1.
62. Azzi A. How can a chemically well established antioxidant work differently when in the body? IUBMB Life 2009;61:1159-1160.
63. Lofstedt J. White muscle disease of foals. Vet Clin North Am Equine Pract 1997;13:169-185.
64. Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr 2007;27:347-362.
65. Singer E. Effects of vitamin E deficiency on the thyroid gland of the rat. J Physiol 1936;87:287-290.2.
66. Chang WP, Combs GF, Scanes CG, et al. The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken. Dev Comp Immunol 2005;29:265-273.