Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly

Diabetes

Volumn 60, Issue 8, 2011, Pages 2041-2050

  Wang, Ying ^a   Puthanveetil, Prasanth ^a   Wang, Fang ^a   Kim, Min Suk ^a   Abrahani, Ashraf ^a   Rodrigues, Brian ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN LIKE PROTEIN 4; CALNEXIN; DIAZOXIDE; DIMER; FATTY ACID; GLUCOSE; LIPOPROTEIN LIPASE; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; DIABETES MELLITUS; DIMERIZATION; DISEASE SEVERITY; ENZYME DISASSEMBLY; ENZYME INACTIVATION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; LIPID HYDROLYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; STREPTOZOCIN DIABETES;

ANGIOPOIETINS; ANIMALS; CALNEXIN; DIABETES MELLITUS, EXPERIMENTAL; DIAZOXIDE; FATTY ACIDS, NONESTERIFIED; HYPERGLYCEMIA; LIPOPROTEIN LIPASE; MALE; MYOCARDIUM; PROTEIN MULTIMERIZATION; RATS; RATS, WISTAR; STREPTOZOCIN;

EID: 80052866566     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0042     Document Type: Article

References (50)

1. Akasha AA, Sotiriadou I, Doss MX, et al. Entrapment of embryonic stem cells-derived cardiomyocytes in macroporous biodegradable microspheres: preparation and characterization. Cell Physiol Biochem 2008;22: 665-672
2. An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol 2006;291: H1489-H1506
3. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol Rev 2010;90: 207-258
4. Rodrigues B, Cam MC, McNeill JH. Myocardial substrate metabolism: implications for diabetic cardiomyopathy. J Mol Cell Cardiol 1995;27:169-179
5. Atkinson LL, Fischer MA, Lopaschuk GD. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 2002;277:29424-29430 (Pubitemid 41079226)
6. Saddik M, Lopaschuk GD. Triacylglycerol turnover in isolated working hearts of acutely diabetic rats. Can J Physiol Pharmacol 1994;72:1110-1119
7. Tannock LR, Chait A. Lipoprotein-matrix interactions in macrovascular disease in diabetes. Front Biosci 2004;9:1728-1742 (Pubitemid 38918629)
8. Blanchette-Mackie EJ, Masuno H, Dwyer NK, Olivecrona T, Scow RO. Lipoprotein lipase in myocytes and capillary endothelium of heart: immunocytochemical study. Am J Physiol 1989;256:E818-E828
9. Camps L, Reina M, Llobera M, Vilaró S, Olivecrona T. Lipoprotein lipase: cellular origin and functional distribution. Am J Physiol 1990;258:C673-C681 (Pubitemid 20140652)
10. Eckel RH. Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases. N Engl J Med 1989;320:1060-1068 (Pubitemid 19105751)
11. Enerbäck S, Gimble JM. Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level. Biochim Biophys Acta 1993;1169:107-125 (Pubitemid 23234587)
12. Kim MS, Wang F, Puthanveetil P, et al. Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes. Circ Res 2008;103:252-260
13. Kim MS, Wang F, Puthanveetil P, et al. Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation. Diabetes 2009;58:2464-2475
14. Sambandam N, Abrahani MA, St Pierre E, Al-Atar O, Cam MC, Rodrigues B. Localization of lipoprotein lipase in the diabetic heart: regulation by acute changes in insulin. Arterioscler Thromb Vasc Biol 1999;19:1526-1534 (Pubitemid 29263024)
15. Kim MS, Kewalramani G, Puthanveetil P, et al. Acute diabetes moderates trafficking of cardiac lipoprotein lipase through p38 mitogen-activated protein kinase-dependent actin cytoskeleton organization. Diabetes 2008; 57:64-76
16. Garfinkel AS, Kempner ES, Ben-Zeev O, Nikazy J, James SJ, Schotz MC. Lipoprotein lipase: size of the functional unit determined by radiation inactivation. J Lipid Res 1983;24:775-780 (Pubitemid 13011796)
17. Peterson J, Fujimoto WY, Brunzell JD. Human lipoprotein lipase: relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodies. J Lipid Res 1992;33:1165-1170
18. Wong H, Yang D, Hill JS, Davis RC, Nikazy J, Schotz MC. A molecular biology-based approach to resolve the subunit orientation of lipoprotein lipase. Proc Natl Acad Sci USA 1997;94:5594-5598 (Pubitemid 27241814)
19. Ben-Zeev O, Doolittle MH, Davis RC, Elovson J, Schotz MC. Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartment. J Biol Chem 1992;267:6219-6227
20. Ben-Zeev O, Mao HZ, Doolittle MH. Maturation of lipoprotein lipase in the endoplasmic reticulum. Concurrent formation of functional dimers and inactive aggregates. J Biol Chem 2002;277:10727-10738 (Pubitemid 34968201)
21. Briquet-Laugier V, Ben-Zeev O, White A, Doolittle MH. cld and lec23 are disparate mutations that affect maturation of lipoprotein lipase in the endoplasmic reticulum. J Lipid Res 1999;40:2044-2058 (Pubitemid 29523431)
22. Carroll R, Ben-Zeev O, Doolittle MH, Severson DL. Activation of lipoprotein lipase in cardiac myocytes by glycosylation requires trimming of glucose residues in the endoplasmic reticulum. Biochem J 1992;285:693-696
23. Péterfy M, Ben-Zeev O, Mao HZ, et al. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nat Genet 2007;39: 1483-1487 (Pubitemid 350191343)
24. Peterson J, Bihain BE, Bengtsson-Olivecrona G, Deckelbaum RJ, Carpentier YA, Olivecrona T. Fatty acid control of lipoprotein lipase: a link between energy metabolism and lipid transport. Proc Natl Acad Sci USA 1990;87:909-913
25. Bengtsson G, Olivecrona T. Lipoprotein lipase. Mechanism of product inhibition. Eur J Biochem 1980;106:557-562 (Pubitemid 10025783)
26. Sukonina V, Lookene A, Olivecrona T, Olivecrona G. Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc Natl Acad Sci USA 2006;103:17450-17455 (Pubitemid 44788989)
27. Yau MH, Wang Y, Lam KS, Zhang J, Wu D, Xu A. A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J Biol Chem 2009;284:11942-11952
28. Pulinilkunnil T, Qi D, Ghosh S, et al. Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining. Cardiovasc Res 2003;59:788-797 (Pubitemid 38368695)
29. Foy JM, Furman BL. Effect of single dose administration of diuretics on the blood sugar of alloxan-diabetic mice or mice made hyperglycaemic by the acute administration of diazoxide. Br J Pharmacol 1973;47:124-132
30. Pratz J, Mondot S, Montier F, Cavero I. Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats. J Pharmacol Exp Ther 1991;258:216-222
31. Rodrigues B, Spooner M, Severson DL. Free fatty acids do not release lipoprotein lipase from isolated cardiac myocytes or perfused hearts. Am J Physiol 1992;262:E216-E223
32. Forcheron F, Basset A, Del Carmine P, Beylot M. Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate. Diabetes Metab 2009;35:452-457
33. Josephs T, Waugh H, Kokay I, Grattan D, Thompson M. Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat. J Endocrinol 2007;194:305-312 (Pubitemid 47249669)
34. Chang SF, Reich B, Brunzell JD, Will H. Detailed characterization of the binding site of the lipoprotein lipase-specific monoclonal antibody 5D2. J Lipid Res 1998;39:2350-2359 (Pubitemid 29006298)
35. Voshol PJ, Rensen PC, van Dijk KW, Romijn JA, Havekes LM. Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models. Biochim Biophys Acta 2009; 1791:479-485
36. Noh HL, Yamashita H, Goldberg IJ. Cardiac metabolism and mechanics are altered by genetic loss of lipoprotein triglyceride lipolysis. Cardiovasc Drugs Ther 2006;20:441-444 (Pubitemid 46144221)
37. Noh HL, Okajima K, Molkentin JD, Homma S, Goldberg IJ. Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction. Am J Physiol Endocrinol Metab 2006;291:E755-E760 (Pubitemid 44484917)
38. Rouis M, Lohse P, Dugi KA, et al. Homozygosity for two point mutations in the lipoprotein lipase (LPL) gene in a patient with familial LPL deficiency: LPL(Asp9→Asn, Tyr262→His). J Lipid Res 1996;37:651-661
39. Zhang L, Wu G, Tate CG, Lookene A, Olivecrona G. Calreticulin promotes folding/dimerization of human lipoprotein lipase expressed in insect cells (sf21). J Biol Chem 2003;278:29344-29351 (Pubitemid 36935851)
40. Scow RO, Schultz CJ, Park JW, Blanchette-Mackie EJ. Combined lipase deficiency (cld/cld) in mice affects differently post-translational processing of lipoprotein lipase, hepatic lipase and pancreatic lipase. Chem Phys Lipids 1998;93:149-155 (Pubitemid 28383214)
41. Kennedy J, Katsuta H, Jung MH, et al. Protective unfolded protein response in human pancreatic beta cells transplanted into mice. PLoS ONE 2010;5:e11211
42. Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008;29:42-61 (Pubitemid 351252746)
43. Ma Y, Hendershot LM. ER chaperone functions during normal and stress conditions. J Chem Neuroanat 2004;28:51-65 (Pubitemid 39195252)
44. Zhang L, Lookene A, Wu G, Olivecrona G. Calcium triggers folding of lipoprotein lipase into active dimers. J Biol Chem 2005;280:42580-42591 (Pubitemid 43049216)
45. Thammavongsa V, Mancino L, Raghavan M. Polypeptide substrate recognition by calnexin requires specific conformations of the calnexin protein. J Biol Chem 2005;280:33497-33505 (Pubitemid 41397149)
46. Nguyên DT, Kebache S, Fazel A, et al. Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol Biol Cell 2004;15:4248-4260 (Pubitemid 39122027)
47. Chevet E, Wong HN, Gerber D, et al. Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes. EMBO J 1999;18:3655-3666 (Pubitemid 29308845)
48. Yu X, Burgess SC, Ge H, et al. Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart. Proc Natl Acad Sci USA 2005;102:1767-1772 (Pubitemid 40209242)
49. Ge H, Yang G, Huang L, Motola DL, Pourbahrami T, Li C. Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4. J Biol Chem 2004;279:2038-2045 (Pubitemid 38084475)
50. Staiger H, Haas C, Machann J, et al. Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. Diabetes 2009;58:579-589