Pre-analytical effects of different lithium heparin plasma separation tubes in the routine clinical chemistry laboratory

Clinical Chemistry and Laboratory Medicine

Volumn 49, Issue 9, 2011, Pages 1473-1477

  Brandhorst, Gunnar ^a   Engelmayer, Jutta ^a   Sandra, Götze ^a   Oellerich, Michael ^a   Von Ahsen, Nicolas ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Hemolysis; Interference; Plasma separation tubes; Pre analytical

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHLORIDE; CREATINE KINASE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEPARIN; LACTATE DEHYDROGENASE; LITHIUM; POTASSIUM; SODIUM;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL CHEMISTRY; CONTROLLED STUDY; FEMALE; HEMOLYSIS; HUMAN; HUMAN EXPERIMENT; HYPERLIPIDEMIA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; SEPARATION TECHNIQUE; STATISTICAL SIGNIFICANCE; STORAGE; TUBE; UREA NITROGEN BLOOD LEVEL;

ARTIFACTS; BLOOD CHEMICAL ANALYSIS; BLOOD SPECIMEN COLLECTION; HEPARIN; HUMANS; PLASMA; TIME FACTORS;

EID: 80052861418     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.606     Document Type: Article

References (15)

1. Bush V, Blennerhasset J, Wells A, Dasgupta A. Stability of therapeutic drugs in serum collected in vacutainer serum separator tubes containing a new gel (SST II). Ther Drug Monit 2001;23:259-62. (Pubitemid 32476554)
2. Cai WM, Leader WG, Porter WH, Chandler MH. Influence of serum separator tubes on total and free phenytoin concentrations and dosages. Ther Drug Monit 1993;15:427-30. (Pubitemid 23297246)
3. Dasgupta A, Yared MA, Wells A. Time-dependent absorption of therapeutic drugs by the gel of the Greiner Vacuette blood collection tube. Ther Drug Monit 2000;22:427-31. (Pubitemid 30622115)
4. Shipkova M, Weisbeck J, Wieland E. Effect of sample storage in sarstedt lithium heparin gel tubes (GT) on drug concentrations. Clin Chem Lab Med 2010;49:E52 wabstractx.
5. Herzum I, Bunder R, Renz H, Wahl HG. Reliability of IFCC method for lactate dehydrogenase measurement in lithium-heparin plasma samples. Clin Chem 2003;49:2094-6. (Pubitemid 37449487)
6. O'Keane MP, Cunningham SK. Evaluation of three different specimen types (serum, plasma lithium heparin and serum gel separator) for analysis of certain analytes: clinical significance of differences in results and efficiency in use. Clin Chem Lab Med 2006;44:662-8. (Pubitemid 43735644)
7. Sylte MS, Wentzel-Larsen T, Bolann BJ. Estimation of the minimal preanalytical uncertainty for 15 clinical chemistry serum analytes. Clin Chem 2010;56:1329-35.
8. Tanner M, Kent N, Smith B, Fletcher S, Lewer M. Stability of common biochemical analytes in serum gel tubes subjected to various storage temperatures and times pre-centrifugation. Ann Clin Biochem 2008;45:375-9. (Pubitemid 352031544)
9. Zeger SL, Liang KY. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986;42:121-30.
10. Ricos C, Alvarez V, Cava F, Garcia-Lario JV, Hernandez A, Jimenez CV, et al. Current databases on biological variation: pros, cons and progress. Scand J Clin Lab Invest 1999;59:491-500. (Pubitemid 30056739)
11. Boyanton BL Jr, Blick KE. Stability studies of twenty-four analytes in human plasma and serum. Clin Chem 2002;48:2242-7. (Pubitemid 35397569)
12. World Health Organization. Use of anticoagulants in diagnostic laboratory investigations and stability of blood, plasma and serum samples. Available at: http://whqlibdoc.who.int/hq/2002/WHO-DIL-LAB-99.1-Rev.2.pdf. Accessed 3 February, 2011.
13. Fraser CG, Cummings ST, Wilkinson SP, Neville RG, Knox JD, Ho O, et al. Biological variability of 26 clinical chemistry analytes in elderly people. Clin Chem 1989;35:783-6. (Pubitemid 19162071)
14. Salvagno GL, Lippi G, Montagnana M, Brocco G, Guidi GC. Non-homogeneous separation of triglycerides, gamma-glutamyltransferase, C-reactive protein and lactate dehydrogenase after centrifugation of lithium-heparin tubes. Clin Chem Lab Med 2008;46:1180-2.
15. Lutomski DM, Bower RH. The effect of thrombocytosis on serum potassium and phosphorus concentrations. Am J Med Sci 1994;307:255-8. (Pubitemid 24109148)