The effect of pulsatile flow on intrathecal drug delivery in the spinal canal

Annals of Biomedical Engineering

Volumn 39, Issue 10, 2011, Pages 2592-2602

  Hettiarachchi, H D M ^a   Hsu, Ying ^a   Harris Jr , Timothy J ^a   Linninger, Andreas A ^a  

^a University of Illinois at Chicago   (United States)

Author keywords

Accelerated transport; Cerebrospinal fluid; CNS diseases; Drug dispersion; IT therapy design; Oscillatory flow

Indexed keywords

ACCELERATED TRANSPORT; BACLOFEN; CEREBRO SPINAL FLUIDS; CEREBROSPINAL FLUID; CLINICAL STUDY; COMPUTATIONAL PREDICTIONS; COMPUTATIONAL STUDIES; DRUG TRANSPORT; EXPERIMENTAL OBSERVATION; FLOW CONDITION; FLOW OSCILLATIONS; FLUORESCENT DYES; INTRATHECAL; MOLECULAR DIFFUSION; OSCILLATORY FLOWS; RATIONAL DESIGN; SPINAL CANALS; SURROGATE MODEL; THERAPY DESIGN;

BODY FLUIDS; BRAIN; COMPUTER SIMULATION; DISPERSIONS; DRUG DELIVERY; FLUORESCENCE; HYDRAULIC STRUCTURES; NUCLEAR MEDICINE; PULSATILE FLOW; TOMOGRAPHY; TRANSPORT PROPERTIES;

SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;

BACLOFEN;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; CEREBROSPINAL FLUID; COMPUTER SIMULATION; HISTOLOGY; HUMAN; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; PHYSIOLOGY; PULSATILE FLOW; SPASTICITY; VERTEBRAL CANAL;

ALGORITHMS; BACLOFEN; CEREBROSPINAL FLUID; COMPUTER SIMULATION; HUMANS; INJECTIONS, SPINAL; MODELS, BIOLOGICAL; MUSCLE SPASTICITY; PULSATILE FLOW; SPINAL CANAL;

EID: 80052858864     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-011-0346-x     Document Type: Article

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