Understanding pharmacokinetics using realistic computational models of fluid dynamics: Biosimulation of drug distribution within the CSF space for intrathecal drugs

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 37, Issue 6, 2010, Pages 629-644

  Kuttler, Andreas ^a   Dimke, Thomas ^a   Kern, Steven ^a   Helmlinger, Gabriel ^b   Stanski, Donald ^a   Finelli, Luca A ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Biophysics; Cerebrospinal fluid; CFD; Computational fluid dynamics; CSF; Intrathecal; Pharmacokinetics; PK; SCI; Spinal cord injury

Indexed keywords

ANESTHETIC AGENT; NOGO A ANTIBODY;

BIOPHYSICS; COMPARTMENT MODEL; COMPUTATIONAL FLUID DYNAMICS; COMPUTER MODEL; CONFERENCE PAPER; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG TRANSPORT; HUMAN; INTRATHECAL DRUG ADMINISTRATION; MOLECULAR THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; OSCILLATION; PRIORITY JOURNAL; SIMULATION; SPINAL CORD INJURY;

ANIMALS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HUMANS; HYDRODYNAMICS; INJECTIONS, SPINAL; MODELS, ANATOMIC; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SPINAL CANAL; SPINAL CORD INJURIES; TISSUE DISTRIBUTION;

EID: 79951771383     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-010-9184-y     Document Type: Conference Paper

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