Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass

Diabetes

Volumn 60, Issue 8, 2011, Pages 2076-2085

  Nguidjoe, Evrard ^a   Sokolow, Sophie ^a,e   Bigabwa, Serge ^a   Pachera, Nathalie ^a   D'Amico, Eva ^a   Allagnat, Florent ^a   Vanderwinden, Jean Marie ^a   Sener, Abdullah ^a   Manto, Mario ^a   Depreter, Marianne ^b   Mast, Jan ^b   Joanny, Geraldine ^c   Montanya, Eduard ^c   Rahier, Jacques ^d   Cardozo, Alessandra K ^a   Eizirik, Décio L ^a   Schurmans, Stéphane ^a,f   Herchuelz, André ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b VETERINARY AND AGROCHEMICAL RESEARCH CENTRE   (Belgium)

^c BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GROWTH HORMONE; INSULIN; PROINSULIN; SODIUM CALCIUM EXCHANGE PROTEIN;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL FUNCTION; CELL MASS; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; FEMALE; GENE INACTIVATION; GENE MUTATION; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GROWTH HORMONE BLOOD LEVEL; HETEROZYGOSITY; HYPOXIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; KIDNEY CAPSULE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; CALCIUM; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; SODIUM-CALCIUM EXCHANGER;

EID: 80052846979     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0924     Document Type: Article

References (41)

1. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-1431
2. Yang W, Lu J, Weng J, et al.; China National Diabetes and Metabolic Disorders Study Group. Prevalence of diabetes among men and women in China. N Engl J Med 2010;362:1090-1101
3. Utzschneider KM, Kahn SE. b-cell dysfunction in type 2 diabetes. In International Textbook of Diabetes Mellitus. DeFronzo RA, Ferrannini E, Keen H, Zimmet P, Eds. Hoboken, NJ, John Wiley & Sons, Ltd, 2003, p. 375-388
4. Porte D Jr. Banting lecture 1990. Beta-cells in type II diabetes mellitus. Diabetes 1991;40:166-180
5. Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009;52:1003-1012
6. MacLean N, Ogilvie RF. Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes 1955;4:367-376
7. Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC. Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 2008;10(Suppl. 4):32-42
8. Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005;54(Suppl. 2):S97-S107 (Pubitemid 43343337)
9. Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev 1999;79:763-854 (Pubitemid 29330173)
10. 2+ exchange molecule: an overview. Ann N Y Acad Sci 2002;976:1-10
11. Diaz-Horta O, Kamagate A, Herchuelz A, Van Eylen F. Na/Ca exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells. Diabetes 2002; 51:1815-1824 (Pubitemid 34564294)
12. Sokolow S, Manto M, Gailly P, et al. Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. J Clin Invest 2004;113:265-273 (Pubitemid 38544211)
13. 2+ outflow and entry in the rat pancreatic beta-cell: studies with antisense oligonucleotides. Diabetes 1998;47:1873-1880
14. Plasman PO, Lebrun P, Herchuelz A. Characterization of the process of sodium-calcium exchange in pancreatic islet cells. Am J Physiol 1990;259:E844-E850
15. Herchuelz A, Malaisse WJ. Regulation of calcium fluxes in pancreatic islets: dissociation between calcium and insulin release. J Physiol 1978;283:409-424 (Pubitemid 9048118)
16. Malaisse WJ, Sener A. Hexose metabolism in pancreatic islets. Feedback control of D-glucose oxidation by functional events. Biochim Biophys Acta 1988;971:246-254
17. Hutton JC, Sener A, Malaisse WJ. The metabolism of 4-methyl-2- oxopentanoate in rat pancreatic islets. Biochem J 1979;184:291-301 (Pubitemid 10182930)
18. Sempoux C, Guiot Y, Dahan K, et al. The focal form of persistent hyper-insulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma. Diabetes 2003;52:784-794 (Pubitemid 36323587)
19. Jacoby M, Cox JJ, Gayral S, et al. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet 2009;41:1027-1031
20. Mast J, Nanbru C, van den Berg T, Meulemans G. Ultrastructural changes of the tracheal epithelium after vaccination of day-old chickens with the La Sota strain of Newcastle disease virus. Vet Pathol 2005;42:559-565
21. Téllez N, Montolio M, Biarnés M, Castaño E, Soler J, Montanya E. Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets. Gene Ther 2005;12:120-128 (Pubitemid 40185915)
22. Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of β-cells in aged adult mice. Diabetes 2005;54:2557-2567 (Pubitemid 41233576)
23. 2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells. Diabetes 2005;54:452-461
24. Biarnés M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 2002;51:66-72 (Pubitemid 34517981)
25. Emamaullee JA, Rajotte RV, Liston P, et al. XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes. Diabetes 2005;54:2541-2548 (Pubitemid 41233574)
26. Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1997;88:561-572 (Pubitemid 27154421)
27. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008;51:216-226
28. Koushik SV, Wang J, Rogers R, et al. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J 2001;15:1209-1211
29. 2+ as evidences in single pancreatic islets. J Biol Chem 1993;268:22265-22268
30. 2+ and insulin release in glucose-stimulated pancreatic islets. J Biol Chem 1994;269:8749-8753
31. Malaisse WJ, Sener A, Herchuelz A, Hutton JC. Insulin release: the fuel hypothesis. Metabolism 1979;28:373-386 (Pubitemid 9144335)
32. 45calcium by isolated islets of Langerhans. Endocrinology 1971;88:72-80
33. Van Eylen F, Svoboda M, Herchuelz A. Identification, expression pattern and potential activity of Na/Ca exchanger isoforms in rat pancreatic B-cells. Cell Calcium 1997;21:185-193 (Pubitemid 27146066)
34. 2+ buffering and electrical activity in mouse pancreatic β-cells. Biophys J 1999;76:2018-2028
35. 2+] in the intercellular spaces of the mouse islet of Langerhans. Adv Exp Med Biol 1986;211:31-51
36. 2+ oscillations in pancreatic beta cells. Diabetes Metab 1998;24:30-36
37. i oscillations in mouse pancreatic islets by glucose, α-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates. Biochim Biophys Acta 2000;1523:65-72
38. Emamaullee JA, Shapiro AM. Perspectives in diabetes. Interventional strategies to prevent β-cell apoptosis in islet transplantation. Diabetes 2006;55:1907-1914
39. Heit JJ. Calcineurin/NFAT signaling in the beta-cell: From diabetes to new therapeutics. Bioessays 2007;29:1011-1021 (Pubitemid 47522841)
40. Heit JJ, Apelqvist AA, Gu X, et al. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature 2006;443:345-349 (Pubitemid 44435154)
41. Hamming KSC, Soliman D, Webster NJ, et al. Inhibition of β-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion. Diabetes 2010;59:1686-1693