H +-myo-inositol transporter SLC2A13 as a potential marker for cancer stem cells in an oral squamous cell carcinoma

Current Cancer Drug Targets

Volumn 11, Issue 8, 2011, Pages 966-975

  Lee, D G ^a   Lee, J H ^b   Choi, B K ^a   Kim, M J ^b   Kim, S M ^b   Kim, K S ^a   Chang, K ^a   Park, S H ^a   Bae, Y S ^c   Kwon, B S ^a,d  

^a National Cancer Center   (South Korea)

^b Seoul National University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Hypoxia; Microarray; Oral squamous cell carcinoma; Solute carrier protein family gene; Sphere forming cells; Starvation

Indexed keywords

CARRIER PROTEIN; GENE PRODUCT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MEMBRANE PROTEIN; MYO INOSITOL TRANSPORTER SLC2A13; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN SLC16A4; PROTEIN SLC16A6; PROTEIN SLC2A13; PROTEIN SLC39A10; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CANCER PATIENT; CANCER RECURRENCE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CELL STRAIN MCF 7; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUTH CARCINOMA; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN FAMILY; SQUAMOUS CELL CARCINOMA; UNINDEXED SEQUENCE;

ADENOCARCINOMA; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; CELL LINE, TUMOR; CULTURE MEDIA, SERUM-FREE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; MOUTH NEOPLASMS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ISOFORMS; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 80052844505     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800911797264752     Document Type: Article

References (26)

1. Slaughter, D. P.; Southwick, H. W.; Smejkal, W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 1953, 6, 963-968.
2. Jemal, A.; Siegel, R.; Ward, E.; Hao, Y.; Xu, J.; Murray, T.; Thun, M. J. Cancer statistics, 2008. CA. Cancer. J. Clin. 2008, 58, 71-96.
3. Oh, Y.; Mao, L. Biomarkers in head and neck carcinoma. Curr. Opin. Oncol. 1997, 9, 247-225.
4. Xia, W.; Lau, Y. K.; Zhang, H. Z.; Liu, A. R.; Li, L.; Kiyokawa, N.; Clayman, G. L.; Katz, R. L.; Hung, M. C. Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. Clin. Cancer Res. 1997, 3, 3-9
5. Perez-Ordonez, B.; Beauchemin, M.; Jordan, R. C. Molecular biology of squamous cell carcinoma of the head and neck. J. Clin. Pathol. 2006, 59, 445-453.
6. Singh, S. K.; Clarke, I. D.; Terasaki, M.; Bonn, V. E.; Hawkins, C.; Squire, J.; Dirks, P. B. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003, 63, 5821-5828.
7. Al-Hajj, M.; Wicha, M. S.; Benito-Hernandez, A.; Morrison, S. J.; Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. PNAS 2002, 100, 3983-3988.
8. Eramo, A.; Lotti, F.; Sette, G.; Pilozzi, E.; Biffoni, M.; Di Virgilio, A.; Conticello, C.; Ruco, L.; Peschle, C.; De Maria, R. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death and Differentiation 2008, 15, 504-514.
9. Suetsugu, A.; Nagaki, M.; Aoki, H.; Motohashi, T.; Kunisada, T.; Moriwaki, H. Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem. And Biophys. Res. Comm. 2006, 351, 820-824.
10. O'Brien, C. A.; Pollett, A.; Gallinger, S.; Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445, 106-110.
11. Prince, M. E.; Sivanandan, R.; Kaczorowski, A.; Wolf, G. T.; Kaplan, M. J.; Dalerba, P.; Weissman, I. L.; Clarke, M. F.; Ailles, L. E. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. PNAS 2007, 104, 973-978.
12. Zhang, S.; Balch, C.; Chan, M. W.; Lai, H.; Matei, D.; Schilder, J. M.; Yan, P. S.; Huang, T. H.; Nephew, K. P. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 2008, 68, 4311-4320.
13. Li, C.; Heidt, D. G.; Dalerba, P.; Burant, C. F.; Zhang, L.; Adsay, V.; Wicha, M.; Clarke, M. F.; Simeone, D. M. Identification of pancreatic cancer stem cells. Cancer Res. 2007, 67, 1030-1037.
14. Gunthert, U.; Hofmann, M.; Rudy, W.; Reber, S.; Zoller, M. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 1991, 65, 13-24.
15. Mack, B.; Gires, O. CD44s and CD44v6 expression in head and neck epithelia. PLoS One 2008, 3 (10), e3360.
16. Shmelkov, S. V.; Butler, J. M.; Hooper, A. T.; Hormigo, A.; Kushner, J.; Milde, T.; Clair, R. St.; Baljevic, M.; White, I.; Jin, D. K.; Chadburn, A.; Murphy, A. J.; Valenzuela, D. M.; Gale, N. W.; Thurston, G.; Yancopoulos, G. D.; D'Angelica, M.; Kemeny, N.; Lyden, D.; Rafii, S. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cellsinitiate tumors. J. Clin. Invest. 2008, 118, 2111-2120.
17. Liu, J.; Karypis, G.; Hippen, K. L.; Vegoe, A. L.; Ruiz, P.; Gilkeson, G. S.; Behrens, T. W. Genomic view of systemic autoimmunity in MRLlpr mice. Genes Immun. 2006, 7, 156-168.
18. Halestrap, A. P.; Price, N. T. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 1999, 343, Pt 2:281-299.
19. Tavaluc, R. T.; Hart, L. S.; Dicker, D. T.; El-Deiry, W. S. Effects of low confluency, serum starvation and hypoxia on the side population of cancer cell lines. Cell Cycle 2007, 6, 2554-2562.
20. Soeda, A.; Park, M.; Lee, D.; Mintz, A.; Androutsellis-Theotokis, A.; McKay, R. D.; Engh, J.; Iwama, T.; Kunisada, T.; Kassam, A. B.; Pollack, I. F.; Park, D. M. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF- 1alpha. Oncogene 2009, 28, 3949-3959.
21. Pouyssegur, J.; Dayan, F.; Mazure, N. M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006, 441, 437-443
22. Joost, H. G.; Thorens, B. The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members. Mol. Membr. Biol. 2001, 18, 247-256.
23. Uldry, M.; Ibberson, M.; Horisberger, J. D.; Chatton, J. Y.; Riederer, B. M.; Thorens, B. Identification of a mammalian H(+)- myo-inositol symporter expressed predominantly in the brain. EMBO J. 2001, 20, 4467-4477.
24. Chepko, G.; Slack, R.; Carbott, D. Differential alteration of stem and other cell populations in ducts and lobules of TGFalpha and c- Myc transgenic mouse mammary epithelium. Tissue Cell 2005, 37, 393-412
25. Huang, Y. Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy. Cancer Metastasis Rev. 2007, 26, 183-201.
26. di, Daniel E.; Mok, M. H.; Mead, E.; Mutinelli, C.; Zambello, E.; Caberlotto, L. L.; Pell, T. J.; Langmead, C. J.; Shah, A. J.; Duddy, G.; Kew, J. N.; Maycox, P. R. Evaluation of expression and function of the H+/myo-inositol transporter HMIT. BMC Cell Biol. 2009, 16, 10:54.