Differential effect of clopidogrel and aspirin on the release of BDNF from platelets

Journal of Neuroimmunology

Volumn 238, Issue 1-2, 2011, Pages 104-106

  Stoll, Paul ^a   Plessow, Annett ^a   Bratke, Kai ^a   Virchow, J Christian ^a   Lommatzsch, Marek ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Aspirin; Brain derived neurotrophic factor; Clopidogrel; Platelet; Stroke

Indexed keywords

ACETYLSALICYLIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CLOPIDOGREL; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DRUG ACTIVITY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; SINGLE DRUG DOSE; THROMBOCYTE; THROMBOCYTE COUNT;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BLOOD PLATELETS; BRAIN-DERIVED NEUROTROPHIC FACTOR; GENE EXPRESSION REGULATION; HUMANS; MALE; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 80052841240     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.06.015     Document Type: Article

References (14)

1. Adams R.J., Albers G., Alberts M.J., Benavente O., Furie K., Goldstein L.B., Gorelick P., Halperin J., Harbaugh R., Johnston S.C., Katzan I., Kelly-Hayes M., Kenton E.J., Marks M., Sacco R.L., Schwamm L.H. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke 2008, 39:1647-1652.
2. D'Andrea G., Joseph R., Cananzi A.R., Ferro-Milone F., Grunfeld S., Toldo M., Welch M.A. Platelet alpha granule secretion in cerebral ischemia: effect of short and long term low dose aspirin treatment. Funct. Neurol. 1988, 3:179-185.
3. Fujimura H., Altar C.A., Chen R., Nakamura T., Nakahashi T., Kambayashi J., Sun B., Tandon N.N. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb. Haemost. 2002, 87:728-734.
4. Jiang Y., Wei N., Lu T., Zhu J., Xu G., Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 2011, 172:398-405.
5. Ke Z., Yip S.P., Li L., Zheng X.X., Tong K.Y. The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. PLoS One 2011, 6:e16643.
6. Liu H.S., Shen H., Harvey B.K., Castillo P., Lu H., Yang Y., Wang Y. Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats. NeuroImage 2011, [Epub ahead of print].
7. Lommatzsch M., Zingler D., Schuhbaeck K., Schloetcke K., Zingler C., Schuff-Werner P., Virchow J.C. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 2005, 26:115-123.
8. Massa S.M., Yang T., Xie Y., Shi J., Bilgen M., Joyce J.N., Nehama D., Rajadas J., Longo F.M. Small molecule BDNF mimetics activate trkb signaling and prevent neuronal degeneration in rodents. J Clin Invest 2010, 120:1774-1785.
9. Nagahara A.H., Tuszynski M.H. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 2011, 10:209-219.
10. Ploughman M., Windle V., MacLellan C.L., White N., Dore J.J., Corbett D. Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke 2009, 40:1490-1495.
11. Sacco R.L., Diener H.C., Yusuf S., Cotton D., Ounpuu S., Lawton W.A., Palesch Y., Martin R.H., Albers G.W., Bath P., Bornstein N., Chan B.P., Chen S.T., Cunha L., Dahlof B., De Keyser J., Donnan G.A., Estol C., Gorelick P., Gu V., Hermansson K., Hilbrich L., Kaste M., Lu C., Machnig T., Pais P., Roberts R., Skvortsova V., Teal P., Toni D., Vandermaelen C., Voigt T., Weber M., Yoon B.W. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J. Med. 2008, 359:1238-1251.
12. Schabitz W.R., Steigleder T., Cooper-Kuhn C.M., Schwab S., Sommer C., Schneider A., Kuhn H.G. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke 2007, 38:2165-2172.
13. Storey R.F. Biology and pharmacology of the platelet p2y12 receptor. Curr. Pharm. Des. 2006, 12:1255-1259.
14. Vorchheimer D.A., Becker R. Platelets in atherothrombosis. Mayo Clin. Proc. 2006, 81:59-68.