메뉴 건너뛰기




Volumn 49, Issue 11, 2011, Pages 2883-2889

Ochratoxin A reduces aflatoxin B1 induced DNA damage detected by the comet assay in Hep G2 cells

Author keywords

Aflatoxin B1; Combined genotoxicity; Comet assay; Hep G2; Mycotoxins; Ochratoxin A

Indexed keywords

AFLATOXIN B1; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; MYCOTOXIN; OCHRATOXIN; REACTIVE OXYGEN METABOLITE; RESTRICTION ENDONUCLEASE;

EID: 80052834802     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.07.029     Document Type: Article
Times cited : (65)

References (49)
  • 1
    • 33846061830 scopus 로고    scopus 로고
    • Oxidative DNA damage induced by ochratoxin A in the HK-2 human kidney cell line: evidence of the relationship with cytotoxicity
    • Arbillaga L., Azqueta A., Ezpeleta O., Lopez de Cerain A. Oxidative DNA damage induced by ochratoxin A in the HK-2 human kidney cell line: evidence of the relationship with cytotoxicity. Mutagenesis 2007, 22:35-42.
    • (2007) Mutagenesis , vol.22 , pp. 35-42
    • Arbillaga, L.1    Azqueta, A.2    Ezpeleta, O.3    Lopez de Cerain, A.4
  • 2
    • 2542574143 scopus 로고    scopus 로고
    • ¿Es la Ocratoxina A una micotoxina mutagénica? (Is the Ochratoxin A a mutagenic mycotoxine?)
    • Arbillaga L., Ezpeleta O., Lopez de Cerain A. ¿Es la Ocratoxina A una micotoxina mutagénica (Is the Ochratoxin A a mutagenic mycotoxine?). Revista de Toxicología 2004, 21:1-10.
    • (2004) Revista de Toxicología , vol.21 , pp. 1-10
    • Arbillaga, L.1    Ezpeleta, O.2    Lopez de Cerain, A.3
  • 3
    • 33746718046 scopus 로고    scopus 로고
    • Aflatoxin B1-induced DNA damage and its repair
    • Bedard L.L., Massey T.E. Aflatoxin B1-induced DNA damage and its repair. Cancer Lett. 2006, 241:174-183.
    • (2006) Cancer Lett. , vol.241 , pp. 174-183
    • Bedard, L.L.1    Massey, T.E.2
  • 4
    • 34547830857 scopus 로고    scopus 로고
    • Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients
    • Binder E.M., Tan L.M., Chin L.J., Handl J., Richard J. Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients. Anim. Feed Sci. Technol. 2007, 137:265-282.
    • (2007) Anim. Feed Sci. Technol. , vol.137 , pp. 265-282
    • Binder, E.M.1    Tan, L.M.2    Chin, L.J.3    Handl, J.4    Richard, J.5
  • 5
    • 84920733902 scopus 로고    scopus 로고
    • Spreadsheet to calculate voltages and currents in an electrophoresis tank
    • Available from
    • Brunborg, G., 2008. Spreadsheet to calculate voltages and currents in an electrophoresis tank. Available from: http://comics.vitamib.com/electrophoresis-physics.
    • (2008)
    • Brunborg, G.1
  • 7
    • 8544283254 scopus 로고    scopus 로고
    • The comet assay for DNA damage and repair: principles, applications, and limitations
    • Collins A.R. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 2004, 26:249-261.
    • (2004) Mol. Biotechnol. , vol.26 , pp. 249-261
    • Collins, A.R.1
  • 8
    • 1842837108 scopus 로고    scopus 로고
    • Oxidation of cellular DNA measured with the comet assay
    • Collins A.R., Dusinska M. Oxidation of cellular DNA measured with the comet assay. Methods Mol. Biol. 2002, 186:147-159.
    • (2002) Methods Mol. Biol. , vol.186 , pp. 147-159
    • Collins, A.R.1    Dusinska, M.2
  • 9
    • 0034916609 scopus 로고    scopus 로고
    • Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay
    • Collins A.R., Dusinska M., Horvathova E., Munro E., Savio M., Stetina R. Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay. Mutagenesis 2001, 16:297-301.
    • (2001) Mutagenesis , vol.16 , pp. 297-301
    • Collins, A.R.1    Dusinska, M.2    Horvathova, E.3    Munro, E.4    Savio, M.5    Stetina, R.6
  • 11
    • 34547817107 scopus 로고    scopus 로고
    • Catechins: natural free-radical scavengers against ochratoxin A-induced cell damage in a pig kidney cell line (LLC-PK1)
    • Costa S., Utan A., Cervellati R., Speroni E., Guerra M.C. Catechins: natural free-radical scavengers against ochratoxin A-induced cell damage in a pig kidney cell line (LLC-PK1). Food Chem. Toxicol. 2007, 45:1910-1917.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1910-1917
    • Costa, S.1    Utan, A.2    Cervellati, R.3    Speroni, E.4    Guerra, M.C.5
  • 12
    • 3543069308 scopus 로고    scopus 로고
    • Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity?
    • Creppy E.E., Chiarappa P., Baudrimont I., Borracci P., Moukha S., Carratu M.R. Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity?. Toxicology 2004, 201:115-123.
    • (2004) Toxicology , vol.201 , pp. 115-123
    • Creppy, E.E.1    Chiarappa, P.2    Baudrimont, I.3    Borracci, P.4    Moukha, S.5    Carratu, M.R.6
  • 13
    • 80053588861 scopus 로고    scopus 로고
    • EFSA,. Opinion of the Scientific Panel on Contaminats in the Food Chain on a request from the Commission related to the potential increase of consumer health risk by a possible increase of the existing maximun levels for Aflatoxins in almonds, hazelnuts and pistachios and derived products. EFSA J.
    • EFSA, 2007. Opinion of the Scientific Panel on Contaminats in the Food Chain on a request from the Commission related to the potential increase of consumer health risk by a possible increase of the existing maximun levels for Aflatoxins in almonds, hazelnuts and pistachios and derived products. EFSA J. 446, 1-127.
    • (2007) , vol.446 , pp. 1-127
  • 14
    • 80053598482 scopus 로고    scopus 로고
    • EFSA. Opinion of the scientific panel on contaminants in the Food Chain on a request from the commission related to Ochratoxin A in food. EFSA J.
    • EFSA, 2006. Opinion of the scientific panel on contaminants in the Food Chain on a request from the commission related to Ochratoxin A in food. EFSA J. 365, 1-56.
    • (2006) , vol.365 , pp. 1-56
  • 16
    • 33747889203 scopus 로고    scopus 로고
    • Induction of Hsp70 in Vero cells in response to mycotoxins cytoprotection by sub-lethal heat shock and by Vitamin E
    • El Golli E., Hassen W., Bouslimi A., Bouaziz C., Ladjimi M.M., Bacha H. Induction of Hsp70 in Vero cells in response to mycotoxins cytoprotection by sub-lethal heat shock and by Vitamin E. Toxicol. Lett. 2006, 166:122-130.
    • (2006) Toxicol. Lett. , vol.166 , pp. 122-130
    • El Golli, E.1    Hassen, W.2    Bouslimi, A.3    Bouaziz, C.4    Ladjimi, M.M.5    Bacha, H.6
  • 18
    • 80053595012 scopus 로고    scopus 로고
    • European Commission, Commission Regulation (EC) No. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs (Text with EEA relevance). OJ L , 20.12.06
    • European Commission, 2006. Commission Regulation (EC) No. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs (Text with EEA relevance). OJ L 364, 20.12.06, pp. 5-24.
    • (2006) , vol.364 , pp. 5-24
  • 19
    • 80053598267 scopus 로고    scopus 로고
    • European Commission,. Commission Regulation (EC) No. 472/2002 of 12 March 2002 amending Regulation (EC) No 466/2001 setting maximum levels for certain contaminants in foodstuffs (Text with EEA relevance). L 75/18.
    • European Commission, 2002. Commission Regulation (EC) No. 472/2002 of 12 March 2002 amending Regulation (EC) No 466/2001 setting maximum levels for certain contaminants in foodstuffs (Text with EEA relevance). L 75/18.
    • (2002)
  • 20
    • 10444268152 scopus 로고    scopus 로고
    • Cytotoxicity and Hsp70 induction in Hep G2 cells in response to zearalenone and cytoprotection by sub-lethal heat shock
    • Hassen W., El Golli E., Baudrimont I., Mobio A.T., Ladjimi M.M., Creppy E.E., Bacha H. Cytotoxicity and Hsp70 induction in Hep G2 cells in response to zearalenone and cytoprotection by sub-lethal heat shock. Toxicology 2005, 207:293-301.
    • (2005) Toxicology , vol.207 , pp. 293-301
    • Hassen, W.1    El Golli, E.2    Baudrimont, I.3    Mobio, A.T.4    Ladjimi, M.M.5    Creppy, E.E.6    Bacha, H.7
  • 21
    • 33644779615 scopus 로고    scopus 로고
    • In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells
    • Heussner A.H., Dietrich D.R., O'Brien E. In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells. Toxicol. In Vitro 2006, 20:332-341.
    • (2006) Toxicol. In Vitro , vol.20 , pp. 332-341
    • Heussner, A.H.1    Dietrich, D.R.2    O'Brien, E.3
  • 22
    • 80053587515 scopus 로고    scopus 로고
    • IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene
    • IARC, 2002. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene, vol. 82, p. 590.
    • (2002) , vol.82 , pp. 590
  • 23
    • 80053597655 scopus 로고
    • IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins
    • IARC, 1993. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins, vol. 56, p. 33.
    • (1993) , vol.56 , pp. 33
  • 24
    • 80053614815 scopus 로고    scopus 로고
    • IARC,. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs
    • IARC, 1987. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1-42(Suppl. 7), p. 440.
    • , vol.1-42 , Issue.SUPPL. 7 , pp. 440
  • 26
    • 33645469269 scopus 로고    scopus 로고
    • DNA adduct formation by ochratoxin A: review of the available evidence
    • Food Addit. Contam
    • Mally, A., Dekant, W., 2005. DNA adduct formation by ochratoxin A: review of the available evidence. Food Addit. Contam. 22(Suppl. 1), 65-74.
    • (2005) , vol.22 , Issue.SUPPL. 1 , pp. 65-74
    • Mally, A.1    Dekant, W.2
  • 30
    • 33645306292 scopus 로고    scopus 로고
    • Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in animals and immortalized human cell lines
    • McKean C., Tang L., Billam M., Tang M., Theodorakis C., Kendall R., Wang J. Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in animals and immortalized human cell lines. J. Appl. Toxicol. 2006, 26:139-147.
    • (2006) J. Appl. Toxicol. , vol.26 , pp. 139-147
    • McKean, C.1    Tang, L.2    Billam, M.3    Tang, M.4    Theodorakis, C.5    Kendall, R.6    Wang, J.7
  • 31
    • 0028965135 scopus 로고
    • Cellular interactions and metabolism of aflatoxin: An update
    • McLean M., Dutton M.F. Cellular interactions and metabolism of aflatoxin: An update. Pharm. Ther. 1995, 65:163-192.
    • (1995) Pharm. Ther. , vol.65 , pp. 163-192
    • McLean, M.1    Dutton, M.F.2
  • 32
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 33
    • 80053585445 scopus 로고    scopus 로고
    • OECD Guideline for the testing of chemicals, Number 473. Adopted 21st July. In vitro Mammalian Chromosome Aberration Tests.
    • OECD Guideline for the testing of chemicals, Number 473. Adopted 21st July 1997. In vitro Mammalian Chromosome Aberration Tests.
    • (1997)
  • 34
    • 80053584150 scopus 로고    scopus 로고
    • OECD Guideline for the testing of chemicals, Number 487. Adopted 22nd July. In vitro Mammalian Cell Micronucleus Test.
    • OECD Guideline for the testing of chemicals, Number 487. Adopted 22nd July 2010. In vitro Mammalian Cell Micronucleus Test.
    • (2010)
  • 35
    • 37749045357 scopus 로고    scopus 로고
    • Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity
    • Otto M., Hansen S.H., Dalgaard L., Dubois J., Badolo L. Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity. Cell Biol. Toxicol. 2008, 24:87-99.
    • (2008) Cell Biol. Toxicol. , vol.24 , pp. 87-99
    • Otto, M.1    Hansen, S.H.2    Dalgaard, L.3    Dubois, J.4    Badolo, L.5
  • 38
    • 34447556898 scopus 로고    scopus 로고
    • Adult hippocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A
    • Sava V., Velasquez A., Song S., Sanchez-Ramos J. Adult hippocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A. Toxicol. Sci. 2007, 98:187-197.
    • (2007) Toxicol. Sci. , vol.98 , pp. 187-197
    • Sava, V.1    Velasquez, A.2    Song, S.3    Sanchez-Ramos, J.4
  • 42
    • 28944449329 scopus 로고    scopus 로고
    • Metabolism-mediated Ochratoxin A genotoxicity in the single-cell gel electrophoresis (Comet) assay
    • Simarro Doorten Y.S., Nijmeijer S., de Nijs-Tjon L., Fink-Gremmels J. Metabolism-mediated Ochratoxin A genotoxicity in the single-cell gel electrophoresis (Comet) assay. Food Chem. Toxicol. 2006, 44:261-270.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 261-270
    • Simarro Doorten, Y.S.1    Nijmeijer, S.2    de Nijs-Tjon, L.3    Fink-Gremmels, J.4
  • 43
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 44
    • 0037076317 scopus 로고    scopus 로고
    • The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma
    • Smela M.E., Hamm M.L., Henderson P.T., Harris C.M., Harris T.M., Essigmann J.M. The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 2002, 99:6655-6660.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6655-6660
    • Smela, M.E.1    Hamm, M.L.2    Henderson, P.T.3    Harris, C.M.4    Harris, T.M.5    Essigmann, J.M.6
  • 45
    • 4444242105 scopus 로고    scopus 로고
    • Combined toxic effects of mycotoxins
    • Speijers G.J.A. Combined toxic effects of mycotoxins. Toxicol. Lett. 2004, 153:91.
    • (2004) Toxicol. Lett. , vol.153 , pp. 91
    • Speijers, G.J.A.1
  • 46
    • 22544479430 scopus 로고    scopus 로고
    • Perspective: ochratoxin A is not a genotoxic carcinogen
    • Turesky R.J. Perspective: ochratoxin A is not a genotoxic carcinogen. Chem. Res. Toxicol. 2005, 18:1082-1090.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1082-1090
    • Turesky, R.J.1
  • 47
    • 0033577712 scopus 로고    scopus 로고
    • Single-cell gel electrophoresis assays with human-derived hepatoma (Hep G2) cells
    • Uhl M., Helma C., Knasmuller S. Single-cell gel electrophoresis assays with human-derived hepatoma (Hep G2) cells. Mutat. Res. 1999, 441:215-224.
    • (1999) Mutat. Res. , vol.441 , pp. 215-224
    • Uhl, M.1    Helma, C.2    Knasmuller, S.3
  • 48
    • 64649086573 scopus 로고    scopus 로고
    • Aflatoxins and its mechanisms of toxicity in hepatic cancer
    • Urrego Novoa J.R., Diaz G.J. Aflatoxins and its mechanisms of toxicity in hepatic cancer. Rev. Fac. Med. Una. 2006, 54:108-116.
    • (2006) Rev. Fac. Med. Una. , vol.54 , pp. 108-116
    • Urrego Novoa, J.R.1    Diaz, G.J.2
  • 49
    • 0032820452 scopus 로고    scopus 로고
    • Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
    • Wang H., Joseph J.A. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic. Biol. Med. 1999, 27:612-616.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 612-616
    • Wang, H.1    Joseph, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.